Jeffrey Kleim

Assoc Professor

  • 7983 Citations
  • 40 h-Index
1991 …2019

Research output per year

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Research Output

2019

Tongue Force Training Induces Plasticity of the Lingual Motor Cortex in Young Adult and Aged Rats

Cullins, M. J., Wenninger, J. M., Cullen, J. S., Russell, J. A., Kleim, J. A. & Connor, N. P., Dec 19 2019, In : Frontiers in Neuroscience. 13, 1355.

Research output: Contribution to journalArticle

Open Access
2018

Coordinated plasticity of synapses and astrocytes underlies practice-driven functional vicariation in peri-infarct motor cortex

Kim, S. Y., Hsu, J. E., Husbands, L. C., Kleim, J. & Jones, T. A., Jan 3 2018, In : Journal of Neuroscience. 38, 1, p. 93-107 15 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Comparison of Electrical and Ultrasound Neurostimulation in Rat Motor Cortex

Gulick, D. W., Li, T., Kleim, J. & Towe, B. C., 2017, (Accepted/In press) In : Ultrasound in Medicine and Biology.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Enhanced Motor Recovery after Stroke with Combined Cortical Stimulation and Rehabilitative Training Is Dependent on Infarct Location

Boychuk, J. A., Schwerin, S. C., Thomas, N., Roger, A., Silvera, G., Liverpool, M., Adkins, D. L. & Kleim, J., Feb 1 2016, In : Neurorehabilitation and Neural Repair. 30, 2, p. 173-181 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Regenerative Rehabilitation and Genomics: Frontiers in Clinical Practice

Ambrosio, F. & Kleim, J., Apr 1 2016, In : Physical Therapy. 96, 4, p. 430-432 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Translating Genomic Advances to Physical Therapist Practice: A Closer Look at the Nature and Nurture of Common Diseases

Curtis, C. L., Goldberg, A., Kleim, J. & Wolf, S. L., Apr 1 2016, In : Physical Therapy. 96, 4, p. 570-580 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Age-dependent reorganization of peri-infarct "premotor" cortex with task-specific rehabilitative training in mice

Tennant, K. A., Kerr, A. L., Adkins, D. L., Donlan, N., Thomas, N., Kleim, J. & Jones, T. A., Mar 2 2015, In : Neurorehabilitation and Neural Repair. 29, 2, p. 193-202 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Experience with the “good” limb induces aberrant synaptic plasticity in the perilesion cortex after stroke

Kim, S. Y., Allred, R. P., De Adkins, A. L., Tennant, K. A., Donlan, N. A., Kleim, J. & Jones, T. A., Jun 3 2015, In : Journal of Neuroscience. 35, 22, p. 8604-8610 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Linking genes to neurological clinical practice: The genomic basis for neurorehabilitation

Goldberg, A., Curtis, C. L. & Kleim, J., Jan 2015, In : Journal of Neurologic Physical Therapy. 39, 1, p. 52-61 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Targeted motor rehabilitation dissociates corticobulbar versus corticospinal dysfunction in an animal model of parkinson's disease

Plowman, E. K., Maling, N., Thomas, N. J., Fowler, S. C. & Kleim, J., Jan 1 2014, In : Neurorehabilitation and Neural Repair. 28, 1, p. 85-95 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2013

Differential sensitivity of cranial and limb motor function to nigrostriatal dopamine depletion

Plowman, E. K., Maling, N., Rivera, B. J., Larson, K., Thomas, N. J., Fowler, S. C., Manfredsson, F. P., Shrivastav, R. & Kleim, J., Jan 15 2013, In : Behavioural Brain Research. 237, 1, p. 157-163 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Effects of aerobic fitness on aging-related changes of interhemispheric inhibition and motor performance

McGregor, K. M., Nocera, J. R., Sudhyadhom, A., Patten, C., Manini, T. M., Kleim, J., Crosson, B. & Butler, A. J., Jan 1 2013, In : Frontiers in Aging Neuroscience. 5, OCT, Article 66.

Research output: Contribution to journalArticle

31 Scopus citations

Motor skill learning induces changes in white matter microstructure and myelination

Sampaio-Baptista, C., Khrapitchev, A. A., Foxley, S., Schlagheck, T., Scholz, J., Jbabdi, S., DeLuca, G. C., Miller, K. L., Taylor, A., Thomas, N., Kleim, J., Sibson, N. R., Bannerman, D. & Johansen-Berg, H., 2013, In : Journal of Neuroscience. 33, 50, p. 19499-19503 5 p.

Research output: Contribution to journalArticle

211 Scopus citations
2012

Motor map reliability and aging: A TMS/fMRI study

McGregor, K. M., Carpenter, H., Kleim, E., Sudhyadhom, A., White, K. D., Butler, A. J., Kleim, J. & Crosson, B., May 1 2012, In : Experimental Brain Research. 219, 1, p. 97-106 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Skill learning induced plasticity of motor cortical representations is time and age-dependent

Tennant, K. A., Adkins, D. L., Scalco, M. D., Donlan, N. A., Asay, A. L., Thomas, N., Kleim, J. & Jones, T. A., Oct 1 2012, In : Neurobiology of Learning and Memory. 98, 3, p. 291-302 12 p.

Research output: Contribution to journalArticle

38 Scopus citations
2011

Behavioral and neurophysiological correlates of striatal dopamine depletion: A rodent model of Parkinson's disease

Plowman, E. K. & Kleim, J., Sep 1 2011, In : Journal of Communication Disorders. 44, 5, p. 549-556 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Distributed versus focal cortical stimulation to enhance motor function and motor map plasticity in a rodent model of ischemia

Boychuk, J. A., Adkins, D. A. L. & Kleim, J. A., Jan 1 2011, In : Neurorehabilitation and Neural Repair. 25, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Neural plasticity and neurorehabilitation: Teaching the new brain old tricks

Kleim, J., Sep 1 2011, In : Journal of Communication Disorders. 44, 5, p. 521-528 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Physical activity and neural correlates of aging: A combined TMS/fMRI study

McGregor, K. M., Zlatar, Z., Kleim, E., Sudhyadhom, A., Bauer, A., Phan, S., Seeds, L., Ford, A., Manini, T. M., White, K. D., Kleim, J. & Crosson, B., Sep 12 2011, In : Behavioural Brain Research. 222, 1, p. 158-168 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Striatal dopamine depletion induces forelimb motor impairments and disrupts forelimb movement representations within the motor cortex

Plowman, E. K., Thomas, N. J. & Kleim, J., Jun 14 2011, In : Journal of Parkinson's Disease. 1, 1, p. 93-100 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

The organization of the forelimb representation of the C57BL/6 mouse motor cortex as defined by intracortical microstimulation and cytoarchitecture

Tennant, K. A., Adkins, D. L., Donlan, N. A., Asay, A. L., Thomas, N., Kleim, J. A. & Jones, T. A., Apr 1 2011, In : Cerebral Cortex. 21, 4, p. 865-876 12 p.

Research output: Contribution to journalArticle

179 Scopus citations
2010

BDNF val66met polymorphism influences motor system function in the human brain

McHughen, S. A., Rodriguez, P. F., Kleim, J. A., Kleim, E. D., Crespo, L. M., Procaccio, V. & Cramer, S. C., May 2010, In : Cerebral Cortex. 20, 5, p. 1254-1262 9 p.

Research output: Contribution to journalArticle

139 Scopus citations

Motor cortex reorganization across the lifespan

Plowman, E. K. & Kleim, J. A., Jul 1 2010, In : Journal of Communication Disorders. 43, 4, p. 286-294 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Motor map plasticity: A neural substrate for improving motor function after stroke

Kleim, J. A. & Schwerin, S., Jan 1 2010, Brain Repair After Stroke. Cambridge University Press, p. 1-10 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Neural plasticity: The biological substrate for neurorehabilitation

Warraich, Z. & Kleim, J. A., Jan 1 2010, In : PM and R. 2, 12 SUPPL, p. S208-S219

Research output: Contribution to journalArticle

84 Scopus citations

Stroke: Working toward a prioritized world agenda

Hachinski, V., Donnan, G. A., Gorelick, P. B., Hacke, W., Cramer, S. C., Kaste, M., Fisher, M., Brainin, M., Buchan, A. M., Lo, E. H., Skolnick, B. E., Furie, K. L., Hankey, G. J., Kivipelto, M., Morris, J., Rothwell, P. M., Sacco, R. L., Smith, S. C., Wang, Y., Bryer, A. & 33 others, Ford, G. A., Iadecola, C., Martins, S. C. O., Saver, J., Skvortsova, V., Bayley, M., Bednar, M. M., Duncan, P., Enney, L., Finklestein, S., Jones, T. A., Kalra, L., Kleim, J., Nitkin, R., Teasell, R., Weiller, C., Desai, B., Goldberg, M. P., Heiss, W. D., Saarelma, O., Schwamm, L. H., Shinohara, Y., Trivedi, B., Wahlgren, N., Wong, L. K., Hakim, A., Norrving, B., Prudhomme, S., Bornstein, N. M., Davis, S. M., Goldstein, L. B., Leys, D. & Tuomilehto, J., Jul 2010, In : Cerebrovascular Diseases. 30, 2, p. 127-147 21 p.

Research output: Contribution to journalReview article

22 Scopus citations

Stroke: Working toward a prioritized world agenda

Hachinski, V., Donnan, G. A., Gorelick, P. B., Hacke, W., Cramer, S. C., Kaste, M., Fisher, M., Brainin, M., Buchan, A. M., Lo, E. H., Skolnick, B. E., Furie, K. L., Hankey, G. J., Kivipelto, M., Morris, J., Rothwell, P. M., Sacco, R. L., Smith, S. C., Wang, Y., Bryer, A. & 33 others, Ford, G. A., Iadecola, C., Martins, S. C. O., Saver, J., Skvortsova, V., Bayley, M., Bednar, M. M., Duncan, P., Enney, L., Finklestein, S., Jones, T. A., Kalra, L., Kleim, J., Nitkin, R., Teasell, R., Weiller, C., Desai, B., Goldberg, M. P., Heiss, W. D., Saarelma, O., Schwamm, L. H., Shinohara, Y., Trivedi, B., Wahlgren, N., Wong, L. K., Hakim, A., Norrving, B., Prudhomme, S., Bornstein, N. M., Davis, S. M., Goldstein, L. B., Leys, D. & Tuomilehto, J., Jun 2010, In : Stroke. 41, 6, p. 1084-1099 16 p.

Research output: Contribution to journalReview article

78 Scopus citations

Stroke: Working toward a prioritized world agenda

Hachinski, V., Donnan, G. A., Gorelick, P. B., Hacke, W., Cramer, S. C., Kaste, M., Fisher, M., Brainin, M., Buchan, A. M., Lo, E. H., Skolnick, B. E., Furie, K. L., Hankey, G. J., Kivipelto, M., Morris, J., Rothwell, P. M., Sacco, R. L., Smith, S. C., Wang, Y., Bryer, A. & 33 others, Ford, G. A., Iadecola, C., Martins, S. C. O., Saver, J., Skvortsova, V., Bayley, M., Bednar, M. M., Duncan, P., Enney, L., Finklestein, S., Jones, T. A., Kalra, L., Kleim, J., Nitkin, R., Teasell, R., Weiller, C., Desai, B., Goldberg, M. P., Heiss, W. D., Saarelma, O., Schwamm, L. H., Shinohara, Y., Trivedi, B., Wahlgren, N., Wong, L. K., Hakim, A., Norrving, B., Prudhomme, S., Bornstein, N. M., Davis, S. M., Goldstein, L. B., Leys, D. & Tuomilehto, J., Aug 2010, In : International Journal of Stroke. 5, 4, p. 238-256 19 p.

Research output: Contribution to journalEditorial

41 Scopus citations

The vermicelli and capellini handling tests: Simple quantitative measures of dexterous forepaw function in rats and mice

Tennant, K. A., Asay, A. L., Allred, R. P., Ozburn, A. R., Kleim, J. A. & Jones, T. A., Jul 2010, In : Journal of Visualized Experiments. 41, e2076.

Research output: Contribution to journalArticle

43 Scopus citations
2009

Brain plasticity and genetic factors

Pearson-Fuhrhop, K. M., Kleim, J. A. & Cramer, S. C., Jan 1 2009, In : Topics in Stroke Rehabilitation. 16, 4, p. 282-299 18 p.

Research output: Contribution to journalReview article

35 Scopus citations

Neural plasticity in motor learning and motor recovery

Kleim, J. A., Dec 1 2009, Pocketbook of Neurological Physiotherapy. Elsevier Ltd., p. 41-50 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Synaptic Mechanisms of Learning

Kleim, J. A., Jan 1 2009, Encyclopedia of Neuroscience. Elsevier Ltd., p. 731-734 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

What do motor "recovery" and "compensationg" mean in patients following stroke?

Levin, M. F., Kleim, J. A. & Wolf, S. L., May 1 2009, In : Neurorehabilitation and Neural Repair. 23, 4, p. 313-319 7 p.

Research output: Contribution to journalArticle

437 Scopus citations
2008

Principles of experience-dependent neural plasticity: Implications for rehabilitation after brain damage

Kleim, J. A. & Jones, T. A., Feb 1 2008, In : Journal of Speech, Language, and Hearing Research. 51, 1, p. S225-S239

Research output: Contribution to journalReview article

975 Scopus citations
2007

A novel phosphodiesterase type 4 inhibitor, HT-0712, enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia

MacDonald, E., Van Der Lee, H., Pocock, D., Cole, C., Thomas, N., VandenBerg, P. M., Bourtchouladze, R. & Kleim, J. A., Nov 1 2007, In : Neurorehabilitation and Neural Repair. 21, 6, p. 486-496 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Brain-derived neurotrophic factor and human motor cortex plasticity

Kleim, J. A., Chan, S., Pringle, E., Schallert, K., Procaccio, V., Jimenez, R. & Cramer, S. C., Apr 1 2007, In : Neuroscientist. 13, 2, 1 p.

Research output: Contribution to journalShort survey

Induction of neocortical long-term depression results in smaller movement representations, fewer excitatory perforated synapses, and more inhibitory synapses

Teskey, G. C., Young, N. A., Van Rooyen, F., Larson, S. E. M., Flynn, C., Monfils, M. H., Kleim, J. A., Henry, L. C. & Goertzen, C. D., Feb 1 2007, In : Cerebral Cortex. 17, 2, p. 434-442 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Motor learning induces astrocytic hypertrophy in the cerebellar cortex

Kleim, J. A., Markham, J. A., Vij, K., Freese, J. L., Ballard, D. H. & Greenough, W. T., Mar 28 2007, In : Behavioural Brain Research. 178, 2, p. 244-249 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

Rat models of upper extremity impairment in stroke

Kleim, J. A., Boychuk, J. A. & Adkins, D. A. L., 2007, In : ILAR Journal. 48, 4, p. 374-384 11 p.

Research output: Contribution to journalReview article

Open Access
51 Scopus citations

Systematic assessment of training-induced changes in corticospinal output to hand using frameless stereotaxic transcranial magnetic stimulation

Kleim, J. A., Kleim, E. D. & Cramer, S. C., Jun 28 2007, In : Nature protocols. 2, 7, p. 1675-1684 10 p.

Research output: Contribution to journalArticle

65 Scopus citations
2006

BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex

Kleim, J. A., Chan, S., Pringle, E., Schallert, K., Procaccio, V., Jimenez, R. & Cramer, S. C., Jun 16 2006, In : Nature Neuroscience. 9, 6, p. 735-737 3 p.

Research output: Contribution to journalArticle

368 Scopus citations

Experience-dependent amelioration of motor impairments in adulthood following neonatal medial frontal cortex injury in rats is accompanied by motor map expansion

Williams, P. T. J., Gharbawie, O. A., Kolb, B. & Kleim, J. A., Aug 1 2006, In : Neuroscience. 141, 3, p. 1315-1326 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

FGF-2-induced cell proliferation stimulates anatomical neurophysiological and functional recovery from neonatal motor cortex injury

Monfils, M. H., Driscoll, I., Kamitakahara, H., Wilson, B., Flynn, C., Teskey, G. C., Kleim, J. A. & Kolb, B., Aug 1 2006, In : European Journal of Neuroscience. 24, 3, p. 739-749 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

III STEP: A basic scientist's perspective

Kleim, J. A., May 1 2006, In : Physical Therapy. 86, 5, p. 614-617 4 p.

Research output: Contribution to journalEditorial

7 Scopus citations

Motor training induces experience-specific patterns of plasticity across motor cortex and spinal cord

Adkins, D. A. L., Boychuk, J., Remple, M. S. & Kleim, J. A., Dec 1 2006, In : Journal of Applied Physiology. 101, 6, p. 1776-1782 7 p.

Research output: Contribution to journalReview article

329 Scopus citations
2005

A quantitative comparison of synaptic density following perfusion versus immersion fixation in the rat cerebral cortex

Monfils, M. H., Bray, D. F., Driscoll, I., Kleim, J. A. & Kolb, B., Aug 15 2005, In : Microscopy Research and Technique. 67, 6, p. 300-304 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Basic fibroblast growth factor stimulates functional recovery after neonatal lesions of motor cortex in rats

Monfils, M. H., Driscoll, I., Vandenberg, P. M., Thomas, N. J., Danka, D., Kleim, J. A. & Kolb, B., Jul 19 2005, In : Neuroscience. 134, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

In search of the motor engram: Motor map plasticity as a mechanism for encoding motor experience

Monfils, M. H., Plautz, E. J. & Kleim, J. A., Oct 1 2005, In : Neuroscientist. 11, 5, p. 471-483 13 p.

Research output: Contribution to journalReview article

193 Scopus citations
39 Scopus citations

Middle cerebral artery (MCA) stroke produces dysfunction in adjacent motor cortex as detected by intracortical microstimulation in rats

Gharbawie, O. A., Gonzalez, C. L. R., Williams, P. T., Kleim, J. A. & Whishaw, I. Q., Jan 1 2005, In : Neuroscience. 130, 3, p. 601-610 10 p.

Research output: Contribution to journalArticle

45 Scopus citations