• 7329 Citations
  • 39 h-Index
1991 …2022
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Research Output 1991 2018

  • 7329 Citations
  • 39 h-Index
  • 71 Article
  • 3 Chapter
2018
3 Citations (Scopus)

Coordinated plasticity of synapses and astrocytes underlies practice-driven functional vicariation in peri-infarct motor cortex

Kim, S. Y., Hsu, J. E., Husbands, L. C., Kleim, J. & Jones, T. A., Jan 3 2018, In : Journal of Neuroscience. 38, 1, p. 93-107 15 p.

Research output: Contribution to journalArticle

Motor Cortex
Astrocytes
Synapses
Anisomycin
Stroke
2017
5 Citations (Scopus)

Comparison of Electrical and Ultrasound Neurostimulation in Rat Motor Cortex

Gulick, D. W., Li, T., Kleim, J. & Towe, B. C., 2017, (Accepted/In press) In : Ultrasound in Medicine and Biology.

Research output: Contribution to journalArticle

cortexes
Motor Cortex
refractory period
Hindlimb
stimulation
2016
3 Citations (Scopus)

Enhanced Motor Recovery after Stroke with Combined Cortical Stimulation and Rehabilitative Training Is Dependent on Infarct Location

Boychuk, J. A., Schwerin, S. C., Thomas, N., Roger, A., Silvera, G., Liverpool, M., Adkins, D. L. & Kleim, J., Feb 1 2016, In : Neurorehabilitation and Neural Repair. 30, 2, p. 173-181 9 p.

Research output: Contribution to journalArticle

Stroke
Middle Cerebral Artery Infarction
Infarction
Internal Capsule
Middle Cerebral Artery
1 Citation (Scopus)

Regenerative Rehabilitation and Genomics: Frontiers in Clinical Practice

Ambrosio, F. & Kleim, J., Apr 1 2016, In : Physical Therapy. 96, 4, p. 430-432 3 p.

Research output: Contribution to journalArticle

Physical Therapy Specialty
Attitude of Health Personnel
Professional Role
Precision Medicine
Regenerative Medicine
2 Citations (Scopus)

Translating Genomic Advances to Physical Therapist Practice: A Closer Look at the Nature and Nurture of Common Diseases

Curtis, C. L., Goldberg, A., Kleim, J. & Wolf, S. L., Apr 1 2016, In : Physical Therapy. 96, 4, p. 570-580 11 p.

Research output: Contribution to journalArticle

Physical Therapists
Exercise
Health
Genomics
Osteoarthritis
2015
23 Citations (Scopus)

Age-dependent reorganization of peri-infarct "premotor" cortex with task-specific rehabilitative training in mice

Tennant, K. A., Kerr, A. L., Adkins, D. L., Donlan, N., Thomas, N., Kleim, J. & Jones, T. A., Mar 2 2015, In : Neurorehabilitation and Neural Repair. 29, 2, p. 193-202 10 p.

Research output: Contribution to journalArticle

Motor Cortex
Forelimb
Stroke
Endothelin-1
Age Groups
18 Citations (Scopus)

Experience with the “good” limb induces aberrant synaptic plasticity in the perilesion cortex after stroke

Kim, S. Y., Allred, R. P., De Adkins, A. L., Tennant, K. A., Donlan, N. A., Kleim, J. & Jones, T. A., Jun 3 2015, In : Journal of Neuroscience. 35, 22, p. 8604-8610 7 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Forelimb
Extremities
Stroke
Motor Cortex
2014
7 Citations (Scopus)

Linking Genes to Neurological Clinical Practice: The Genomic Basis for Neurorehabilitation

Goldberg, A., Curtis, C. L. & Kleim, J., Nov 20 2014, (Accepted/In press) In : Journal of Neurologic Physical Therapy.

Research output: Contribution to journalArticle

Nervous System Diseases
Neuronal Plasticity
Information Science
HapMap Project
Genes
3 Citations (Scopus)

Targeted motor rehabilitation dissociates corticobulbar versus corticospinal dysfunction in an animal model of parkinson's disease

Plowman, E. K., Maling, N., Thomas, N. J., Fowler, S. C. & Kleim, J., Jan 2014, In : Neurorehabilitation and Neural Repair. 28, 1, p. 85-95 11 p.

Research output: Contribution to journalArticle

Parkinson Disease
Rehabilitation
Animal Models
Extremities
Forelimb
2013
10 Citations (Scopus)

Differential sensitivity of cranial and limb motor function to nigrostriatal dopamine depletion

Plowman, E. K., Maling, N., Rivera, B. J., Larson, K., Thomas, N. J., Fowler, S. C., Manfredsson, F. P., Shrivastav, R. & Kleim, J., Jan 15 2013, In : Behavioural Brain Research. 237, 1, p. 157-163 7 p.

Research output: Contribution to journalArticle

Oxidopamine
Dopamine
Extremities
Corpus Striatum
Tyrosine 3-Monooxygenase
27 Citations (Scopus)

Effects of aerobic fitness on aging-related changes of interhemispheric inhibition and motor performance

McGregor, K. M., Nocera, J. R., Sudhyadhom, A., Patten, C., Manini, T. M., Kleim, J., Crosson, B. & Butler, A. J., 2013, In : Frontiers in Aging Neuroscience. 5, OCT, Article 66.

Research output: Contribution to journalArticle

Physical Fitness
Transcranial Magnetic Stimulation
Upper Extremity
Magnetic Resonance Imaging
Individuality
163 Citations (Scopus)

Motor skill learning induces changes in white matter microstructure and myelination

Sampaio-Baptista, C., Khrapitchev, A. A., Foxley, S., Schlagheck, T., Scholz, J., Jbabdi, S., DeLuca, G. C., Miller, K. L., Taylor, A., Thomas, N., Kleim, J., Sibson, N. R., Bannerman, D. & Johansen-Berg, H., 2013, In : Journal of Neuroscience. 33, 50, p. 19499-19503 5 p.

Research output: Contribution to journalArticle

Motor Skills
Learning
Anisotropy
Diffusion Magnetic Resonance Imaging
Motor Cortex
2012
13 Citations (Scopus)

Motor map reliability and aging: A TMS/fMRI study

McGregor, K. M., Carpenter, H., Kleim, E., Sudhyadhom, A., White, K. D., Butler, A. J., Kleim, J. & Crosson, B., May 2012, In : Experimental Brain Research. 219, 1, p. 97-106 10 p.

Research output: Contribution to journalArticle

Transcranial Magnetic Stimulation
Magnetic Resonance Imaging
Young Adult
Age Groups
Muscles
34 Citations (Scopus)

Skill learning induced plasticity of motor cortical representations is time and age-dependent

Tennant, K. A., Adkins, D. L., Scalco, M. D., Donlan, N. A., Asay, A. L., Thomas, N., Kleim, J. & Jones, T. A., Oct 2012, In : Neurobiology of Learning and Memory. 98, 3, p. 291-302 12 p.

Research output: Contribution to journalArticle

Learning
Forelimb
Motor Cortex
Motor Skills
Maintenance
2011
9 Citations (Scopus)

Behavioral and neurophysiological correlates of striatal dopamine depletion: A rodent model of Parkinson's disease

Plowman, E. K. & Kleim, J., Sep 2011, In : Journal of Communication Disorders. 44, 5, p. 549-556 8 p.

Research output: Contribution to journalArticle

Corpus Striatum
motor function
Parkinson Disease
Rodentia
Dopamine
32 Citations (Scopus)

Distributed versus focal cortical stimulation to enhance motor function and motor map plasticity in a rodent model of ischemia

Boychuk, J. A., Adkins, D. L. & Kleim, J., Jan 2011, In : Neurorehabilitation and Neural Repair. 25, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

Rodentia
Rehabilitation
Ischemia
Motor Cortex
Forelimb
44 Citations (Scopus)

Neural plasticity and neurorehabilitation: Teaching the new brain old tricks

Kleim, J., Sep 2011, In : Journal of Communication Disorders. 44, 5, p. 521-528 8 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Teaching
brain
Brain
Brain Diseases
40 Citations (Scopus)

Physical activity and neural correlates of aging: A combined TMS/fMRI study

McGregor, K. M., Zlatar, Z., Kleim, E., Sudhyadhom, A., Bauer, A., Phan, S., Seeds, L., Ford, A., Manini, T. M., White, K. D., Kleim, J. & Crosson, B., Sep 12 2011, In : Behavioural Brain Research. 222, 1, p. 158-168 11 p.

Research output: Contribution to journalArticle

Transcranial Magnetic Stimulation
Motor Cortex
Young Adult
Magnetic Resonance Imaging
Exercise
3 Citations (Scopus)

Striatal dopamine depletion induces forelimb motor impairments and disrupts forelimb movement representations within the motor cortex

Plowman, E. K., Thomas, N. J. & Kleim, J., 2011, In : Journal of Parkinson's Disease. 1, 1, p. 93-100 8 p.

Research output: Contribution to journalArticle

Corpus Striatum
Forelimb
Motor Cortex
Dopamine
Oxidopamine
159 Citations (Scopus)

The organization of the forelimb representation of the C57BL/6 mouse motor cortex as defined by intracortical microstimulation and cytoarchitecture

Tennant, K. A., Adkins, D. L., Donlan, N. A., Asay, A. L., Thomas, N., Kleim, J. & Jones, T. A., Apr 2011, In : Cerebral Cortex. 21, 4, p. 865-876 12 p.

Research output: Contribution to journalArticle

Forelimb
Motor Cortex
Inbred C57BL Mouse
Hindlimb
Vibrissae
2010
124 Citations (Scopus)

BDNF val66met polymorphism influences motor system function in the human brain

McHughen, S. A., Rodriguez, P. F., Kleim, J., Kleim, E. D., Crespo, L. M., Procaccio, V. & Cramer, S. C., May 2010, In : Cerebral Cortex. 20, 5, p. 1254-1262 9 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Brain
Learning
Fingers
Magnetic Resonance Imaging
7 Citations (Scopus)

Motor cortex reorganization across the lifespan

Plowman, E. K. & Kleim, J., Jul 2010, In : Journal of Communication Disorders. 43, 4, p. 286-294 9 p.

Research output: Contribution to journalArticle

Motor Cortex
life-span
reorganization
brain
Brain
5 Citations (Scopus)

Motor map plasticity: A neural substrate for improving motor function after stroke

Kleim, J. & Schwerin, S., Jan 1 2010, Brain Repair After Stroke. Cambridge University Press, Vol. 9780521515337. p. 1-10 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neuronal Plasticity
Stroke
Brain
Aptitude
Edema
72 Citations (Scopus)

Neural plasticity: The biological substrate for neurorehabilitation

Warraich, Z. & Kleim, J., 2010, In : PM and R. 2, 12 SUPPL

Research output: Contribution to journalArticle

Neuronal Plasticity
Central Nervous System
Nervous System Trauma
Central Nervous System Diseases
Nervous System Diseases
34 Citations (Scopus)

Stroke: Working toward a prioritized world agenda

Hachinski, V., Donnan, G. A., Gorelick, P. B., Hacke, W., Cramer, S. C., Kaste, M., Fisher, M., Brainin, M., Buchan, A. M., Lo, E. H., Skolnick, B. E., Furie, K. L., Hankey, G. J., Kivipelto, M., Morris, J., Rothwell, P. M., Sacco, R. L., Smith, S. C., Wang, Y., Bryer, A. & 33 othersFord, G. A., Iadecola, C., Martins, S. C. O., Saver, J., Skvortsova, V., Bayley, M., Bednar, M. M., Duncan, P., Enney, L., Finklestein, S., Jones, T. A., Kalra, L., Kleim, J., Nitkin, R., Teasell, R., Weiller, C., Desai, B., Goldberg, M. P., Heiss, W. D., Saarelma, O., Schwamm, L. H., Shinohara, Y., Trivedi, B., Wahlgren, N., Wong, L. K., Hakim, A., Norrving, B., Prudhomme, S., Bornstein, N. M., Davis, S. M., Goldstein, L. B., Leys, D. & Tuomilehto, J., Aug 2010, In : International Journal of Stroke. 5, 4, p. 238-256 19 p.

Research output: Contribution to journalArticle

Stroke
Organizations
Rehabilitation
Social Marketing
Social Media
73 Citations (Scopus)

Stroke: Working toward a prioritized world agenda

Hachinski, V., Donnan, G. A., Gorelick, P. B., Hacke, W., Cramer, S. C., Kaste, M., Fisher, M., Brainin, M., Buchan, A. M., Lo, E. H., Skolnick, B. E., Furie, K. L., Hankey, G. J., Kivipelto, M., Morris, J., Rothwell, P. M., Sacco, R. L., Smith, S. C., Wang, Y., Bryer, A. & 33 othersFord, G. A., Iadecola, C., Martins, S. C. O., Saver, J., Skvortsova, V., Bayley, M., Bednar, M. M., Duncan, P., Enney, L., Finklestein, S., Jones, T. A., Kalra, L., Kleim, J., Nitkin, R., Teasell, R., Weiller, C., Desai, B., Goldberg, M. P., Heiss, W. D., Saarelma, O., Schwamm, L. H., Shinohara, Y., Trivedi, B., Wahlgren, N., Wong, L. K., Hakim, A., Norrving, B., Prudhomme, S., Bornstein, N. M., Davis, S. M., Goldstein, L. B., Leys, D. & Tuomilehto, J., Jun 2010, In : Stroke. 41, 6, p. 1084-1099 16 p.

Research output: Contribution to journalArticle

Stroke
Organizations
Rehabilitation
Social Marketing
Social Media
22 Citations (Scopus)

Stroke: Working toward a prioritized world agenda

Hachinski, V., Donnan, G. A., Gorelick, P. B., Hacke, W., Cramer, S. C., Kaste, M., Fisher, M., Brainin, M., Buchan, A. M., Lo, E. H., Skolnick, B. E., Furie, K. L., Hankey, G. J., Kivipelto, M., Morris, J., Rothwell, P. M., Sacco, R. L., Smith, S. C., Wang, Y., Bryer, A. & 33 othersFord, G. A., Iadecola, C., Martins, S. C. O., Saver, J., Skvortsova, V., Bayley, M., Bednar, M. M., Duncan, P., Enney, L., Finklestein, S., Jones, T. A., Kalra, L., Kleim, J., Nitkin, R., Teasell, R., Weiller, C., Desai, B., Goldberg, M. P., Heiss, W. D., Saarelma, O., Schwamm, L. H., Shinohara, Y., Trivedi, B., Wahlgren, N., Wong, L. K., Hakim, A., Norrving, B., Prudhomme, S., Bornstein, N. M., Davis, S. M., Goldstein, L. B., Leys, D. & Tuomilehto, J., Jul 2010, In : Cerebrovascular Diseases. 30, 2, p. 127-147 21 p.

Research output: Contribution to journalArticle

Stroke
Organizations
Rehabilitation
Social Marketing
Social Media

Synaptic Mechanisms of Learning

Kleim, J., 2010, Encyclopedia of Neuroscience. Elsevier Ltd, p. 731-734 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Motor Cortex
Neuronal Plasticity
Learning
Motor Skills
Synapses
39 Citations (Scopus)

The vermicelli and capellini handling tests: Simple quantitative measures of dexterous forepaw function in rats and mice

Tennant, K. A., Asay, A. L., Allred, R. P., Ozburn, A. R., Kleim, J. & Jones, T. A., Jul 2010, In : Journal of Visualized Experiments. 41, e2076.

Research output: Contribution to journalArticle

Rats
Social Adjustment
Rodentia
Animals
Testing
2009
34 Citations (Scopus)

Brain plasticity and genetic factors

Pearson-Fuhrhop, K. M., Kleim, J. & Cramer, S. C., Jan 1 2009, In : Topics in Stroke Rehabilitation. 16, 4, p. 282-299 18 p.

Research output: Contribution to journalArticle

Stroke
Brain
Genetic Polymorphisms
Brain-Derived Neurotrophic Factor
Apolipoproteins E

Neural plasticity in motor learning and motor recovery

Kleim, J., 2009, Pocketbook of Neurological Physiotherapy. Elsevier Ltd, p. 41-50 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neuronal Plasticity
Learning
377 Citations (Scopus)

What do motor "recovery" and "compensationg" mean in patients following stroke?

Levin, M. F., Kleim, J. & Wolf, S. L., May 2009, In : Neurorehabilitation and Neural Repair. 23, 4, p. 313-319 7 p.

Research output: Contribution to journalArticle

Interdisciplinary Communication
Aptitude
Terminology
Stroke
Research Personnel
2008
815 Citations (Scopus)
brain damage
Neuronal Plasticity
rehabilitation
brain
Rehabilitation
2007
54 Citations (Scopus)

A novel phosphodiesterase type 4 inhibitor, HT-0712, enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia

MacDonald, E., Van Der Lee, H., Pocock, D., Cole, C., Thomas, N., VandenBerg, P. M., Bourtchouladze, R. & Kleim, J., Nov 2007, In : Neurorehabilitation and Neural Repair. 21, 6, p. 486-496 11 p.

Research output: Contribution to journalArticle

Phosphodiesterase 4 Inhibitors
Forelimb
Motor Cortex
Rehabilitation
Ischemia

Brain-derived neurotrophic factor and human motor cortex plasticity

Kleim, J., Chan, S., Pringle, E., Schallert, K., Procaccio, V., Jimenez, R. & Cramer, S. C., Apr 2007, In : Neuroscientist. 13, 2, p. 98 1 p.

Research output: Contribution to journalArticle

Motor Cortex
human brain-derived neurotrophic factor
34 Citations (Scopus)

Induction of neocortical long-term depression results in smaller movement representations, fewer excitatory perforated synapses, and more inhibitory synapses

Teskey, G. C., Young, N. A., Van Rooyen, F., Larson, S. E. M., Flynn, C., Monfils, M. H., Kleim, J., Henry, L. C. & Goertzen, C. D., Feb 2007, In : Cerebral Cortex. 17, 2, p. 434-442 9 p.

Research output: Contribution to journalArticle

Neocortex
Synapses
Depression
Corpus Callosum
Electrodes
51 Citations (Scopus)

Motor learning induces astrocytic hypertrophy in the cerebellar cortex

Kleim, J., Markham, J. A., Vij, K., Freese, J. L., Ballard, D. H. & Greenough, W. T., Mar 28 2007, In : Behavioural Brain Research. 178, 2, p. 244-249 6 p.

Research output: Contribution to journalArticle

Cerebellar Cortex
Hypertrophy
Learning
Synapses
Motor Skills
45 Citations (Scopus)

Rat models of upper extremity impairment in stroke

Kleim, J., Boychuk, J. A. & Adkins, D. L., 2007, In : ILAR Journal. 48, 4, p. 374-384 11 p.

Research output: Contribution to journalArticle

stroke
Upper Extremity
Rats
animal models
Stroke
59 Citations (Scopus)

Systematic assessment of training-induced changes in corticospinal output to hand using frameless stereotaxic transcranial magnetic stimulation.

Kleim, J., Kleim, E. D. & Cramer, S. C., 2007, In : Nature Protocols. 2, 7, p. 1675-1684 10 p.

Research output: Contribution to journalArticle

Transcranial Magnetic Stimulation
Magnetic resonance imaging
Muscle
Hand
Neuronavigation
2006
342 Citations (Scopus)

BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex

Kleim, J., Chan, S., Pringle, E., Schallert, K., Procaccio, V., Jimenez, R. & Cramer, S. C., Jun 16 2006, In : Nature Neuroscience. 9, 6, p. 735-737 3 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Motor Cortex
Motor Evoked Potentials
Transcranial Magnetic Stimulation
Genes
17 Citations (Scopus)

Experience-dependent amelioration of motor impairments in adulthood following neonatal medial frontal cortex injury in rats is accompanied by motor map expansion

Williams, P. T. J., Gharbawie, O. A., Kolb, B. & Kleim, J., 2006, In : Neuroscience. 141, 3, p. 1315-1326 12 p.

Research output: Contribution to journalArticle

Forelimb
Frontal Lobe
Wounds and Injuries
Brain Injuries
Rehabilitation
41 Citations (Scopus)

FGF-2-induced cell proliferation stimulates anatomical neurophysiological and functional recovery from neonatal motor cortex injury

Monfils, M. H., Driscoll, I., Kamitakahara, H., Wilson, B., Flynn, C., Teskey, G. C., Kleim, J. & Kolb, B., Aug 2006, In : European Journal of Neuroscience. 24, 3, p. 739-749 11 p.

Research output: Contribution to journalArticle

Motor Cortex
Fibroblast Growth Factor 2
Cell Proliferation
Wounds and Injuries
Bromodeoxyuridine
7 Citations (Scopus)

III STEP: A basic scientist's perspective

Kleim, J., May 2006, In : Physical Therapy. 86, 5, p. 614-617 4 p.

Research output: Contribution to journalArticle

Professional-Patient Relations
Physical Therapy Modalities
Patient Participation
Animal Disease Models
Brain Diseases
300 Citations (Scopus)

Motor training induces experience-specific patterns of plasticity across motor cortex and spinal cord

Adkins, D. L., Boychuk, J., Remple, M. S. & Kleim, J., Dec 2006, In : Journal of Applied Physiology. 101, 6, p. 1776-1782 7 p.

Research output: Contribution to journalArticle

Motor Cortex
Spinal Cord
Motor Neurons
Aptitude
Resistance Training
2005
5 Citations (Scopus)

A quantitative comparison of synaptic density following perfusion versus immersion fixation in the rat cerebral cortex

Monfils, M. H., Bray, D. F., Driscoll, I., Kleim, J. & Kolb, B., Aug 15 2005, In : Microscopy Research and Technique. 67, 6, p. 300-304 5 p.

Research output: Contribution to journalArticle

cerebral cortex
Immersion
synapse
Cerebral Cortex
submerging
35 Citations (Scopus)

Basic fibroblast growth factor stimulates functional recovery after neonatal lesions of motor cortex in rats

Monfils, M. H., Driscoll, I., Vandenberg, P. M., Thomas, N. J., Danka, D., Kleim, J. & Kolb, B., 2005, In : Neuroscience. 134, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Motor Cortex
Fibroblast Growth Factor 2
Forelimb
Staining and Labeling
Neurons
183 Citations (Scopus)

In search of the motor engram: Motor map plasticity as a mechanism for encoding motor experience

Monfils, M. H., Plautz, E. J. & Kleim, J., Oct 2005, In : Neuroscientist. 11, 5, p. 471-483 13 p.

Research output: Contribution to journalArticle

Motor Skills
Learning
Recovery of Function
Motor Cortex
Biomechanical Phenomena
38 Citations (Scopus)
Pyramidal Tracts
Forelimb
Motor Cortex
Supination
Extremities
45 Citations (Scopus)

Middle cerebral artery (MCA) stroke produces dysfunction in adjacent motor cortex as detected by intracortical microstimulation in rats

Gharbawie, O. A., Gonzalez, C. L. R., Williams, P. T., Kleim, J. & Whishaw, I. Q., 2005, In : Neuroscience. 130, 3, p. 601-610 10 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Motor Cortex
Forelimb
Middle Cerebral Artery
Pyramidal Tracts
2004
370 Citations (Scopus)

Cortical Synaptogenesis and Motor Map Reorganization Occur during Late, but Not Early, Phase of Motor Skill Learning

Kleim, J., Hogg, T. M., VandenBerg, P. M., Cooper, N. R., Bruneau, R. & Remple, M., Jan 21 2004, In : Journal of Neuroscience. 24, 3, p. 628-633 6 p.

Research output: Contribution to journalArticle

Motor Skills
Synapses
Learning
Forelimb
Motor Cortex