Jeffrey Kleim

Assoc Professor

  • 7854 Citations
  • 40 h-Index
1991 …2022

Research output per year

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Research Output

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2019

Tongue Force Training Induces Plasticity of the Lingual Motor Cortex in Young Adult and Aged Rats

Cullins, M. J., Wenninger, J. M., Cullen, J. S., Russell, J. A., Kleim, J. A. & Connor, N. P., Dec 19 2019, In : Frontiers in Neuroscience. 13, 1355.

Research output: Contribution to journalArticle

Open Access
2018

Coordinated plasticity of synapses and astrocytes underlies practice-driven functional vicariation in peri-infarct motor cortex

Kim, S. Y., Hsu, J. E., Husbands, L. C., Kleim, J. & Jones, T. A., Jan 3 2018, In : Journal of Neuroscience. 38, 1, p. 93-107 15 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Comparison of Electrical and Ultrasound Neurostimulation in Rat Motor Cortex

Gulick, D. W., Li, T., Kleim, J. & Towe, B. C., 2017, (Accepted/In press) In : Ultrasound in Medicine and Biology.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Enhanced Motor Recovery after Stroke with Combined Cortical Stimulation and Rehabilitative Training Is Dependent on Infarct Location

Boychuk, J. A., Schwerin, S. C., Thomas, N., Roger, A., Silvera, G., Liverpool, M., Adkins, D. L. & Kleim, J., Feb 1 2016, In : Neurorehabilitation and Neural Repair. 30, 2, p. 173-181 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Regenerative Rehabilitation and Genomics: Frontiers in Clinical Practice

Ambrosio, F. & Kleim, J., Apr 1 2016, In : Physical Therapy. 96, 4, p. 430-432 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Translating Genomic Advances to Physical Therapist Practice: A Closer Look at the Nature and Nurture of Common Diseases

Curtis, C. L., Goldberg, A., Kleim, J. & Wolf, S. L., Apr 1 2016, In : Physical Therapy. 96, 4, p. 570-580 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Age-dependent reorganization of peri-infarct "premotor" cortex with task-specific rehabilitative training in mice

Tennant, K. A., Kerr, A. L., Adkins, D. L., Donlan, N., Thomas, N., Kleim, J. & Jones, T. A., Mar 2 2015, In : Neurorehabilitation and Neural Repair. 29, 2, p. 193-202 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Experience with the “good” limb induces aberrant synaptic plasticity in the perilesion cortex after stroke

Kim, S. Y., Allred, R. P., De Adkins, A. L., Tennant, K. A., Donlan, N. A., Kleim, J. & Jones, T. A., Jun 3 2015, In : Journal of Neuroscience. 35, 22, p. 8604-8610 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Linking genes to neurological clinical practice: The genomic basis for neurorehabilitation

Goldberg, A., Curtis, C. L. & Kleim, J., Jan 2015, In : Journal of Neurologic Physical Therapy. 39, 1, p. 52-61 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Targeted motor rehabilitation dissociates corticobulbar versus corticospinal dysfunction in an animal model of parkinson's disease

Plowman, E. K., Maling, N., Thomas, N. J., Fowler, S. C. & Kleim, J., Jan 1 2014, In : Neurorehabilitation and Neural Repair. 28, 1, p. 85-95 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2013

Differential sensitivity of cranial and limb motor function to nigrostriatal dopamine depletion

Plowman, E. K., Maling, N., Rivera, B. J., Larson, K., Thomas, N. J., Fowler, S. C., Manfredsson, F. P., Shrivastav, R. & Kleim, J., Jan 15 2013, In : Behavioural Brain Research. 237, 1, p. 157-163 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Effects of aerobic fitness on aging-related changes of interhemispheric inhibition and motor performance

McGregor, K. M., Nocera, J. R., Sudhyadhom, A., Patten, C., Manini, T. M., Kleim, J., Crosson, B. & Butler, A. J., Jan 1 2013, In : Frontiers in Aging Neuroscience. 5, OCT, Article 66.

Research output: Contribution to journalArticle

30 Scopus citations

Motor skill learning induces changes in white matter microstructure and myelination

Sampaio-Baptista, C., Khrapitchev, A. A., Foxley, S., Schlagheck, T., Scholz, J., Jbabdi, S., DeLuca, G. C., Miller, K. L., Taylor, A., Thomas, N., Kleim, J., Sibson, N. R., Bannerman, D. & Johansen-Berg, H., Dec 13 2013, In : Journal of Neuroscience. 33, 50, p. 19499-19503 5 p.

Research output: Contribution to journalArticle

202 Scopus citations
2012

Motor map reliability and aging: A TMS/fMRI study

McGregor, K. M., Carpenter, H., Kleim, E., Sudhyadhom, A., White, K. D., Butler, A. J., Kleim, J. & Crosson, B., May 1 2012, In : Experimental Brain Research. 219, 1, p. 97-106 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Skill learning induced plasticity of motor cortical representations is time and age-dependent

Tennant, K. A., Adkins, D. L., Scalco, M. D., Donlan, N. A., Asay, A. L., Thomas, N., Kleim, J. & Jones, T. A., Oct 1 2012, In : Neurobiology of Learning and Memory. 98, 3, p. 291-302 12 p.

Research output: Contribution to journalArticle

36 Scopus citations
2011

Behavioral and neurophysiological correlates of striatal dopamine depletion: A rodent model of Parkinson's disease

Plowman, E. K. & Kleim, J., Sep 1 2011, In : Journal of Communication Disorders. 44, 5, p. 549-556 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Distributed versus focal cortical stimulation to enhance motor function and motor map plasticity in a rodent model of ischemia

Boychuk, J. A., Adkins, D. A. L. & Kleim, J. A., Jan 1 2011, In : Neurorehabilitation and Neural Repair. 25, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Neural plasticity and neurorehabilitation: Teaching the new brain old tricks

Kleim, J., Sep 1 2011, In : Journal of Communication Disorders. 44, 5, p. 521-528 8 p.

Research output: Contribution to journalArticle

52 Scopus citations

Physical activity and neural correlates of aging: A combined TMS/fMRI study

McGregor, K. M., Zlatar, Z., Kleim, E., Sudhyadhom, A., Bauer, A., Phan, S., Seeds, L., Ford, A., Manini, T. M., White, K. D., Kleim, J. & Crosson, B., Sep 12 2011, In : Behavioural Brain Research. 222, 1, p. 158-168 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Striatal dopamine depletion induces forelimb motor impairments and disrupts forelimb movement representations within the motor cortex

Plowman, E. K., Thomas, N. J. & Kleim, J., Jun 14 2011, In : Journal of Parkinson's Disease. 1, 1, p. 93-100 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

The organization of the forelimb representation of the C57BL/6 mouse motor cortex as defined by intracortical microstimulation and cytoarchitecture

Tennant, K. A., Adkins, D. L., Donlan, N. A., Asay, A. L., Thomas, N., Kleim, J. A. & Jones, T. A., Apr 1 2011, In : Cerebral Cortex. 21, 4, p. 865-876 12 p.

Research output: Contribution to journalArticle

176 Scopus citations
2010

BDNF val66met polymorphism influences motor system function in the human brain

McHughen, S. A., Rodriguez, P. F., Kleim, J. A., Kleim, E. D., Crespo, L. M., Procaccio, V. & Cramer, S. C., May 1 2010, In : Cerebral Cortex. 20, 5, p. 1254-1262 9 p.

Research output: Contribution to journalArticle

135 Scopus citations

Motor cortex reorganization across the lifespan

Plowman, E. K. & Kleim, J. A., Jul 1 2010, In : Journal of Communication Disorders. 43, 4, p. 286-294 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Neural plasticity: The biological substrate for neurorehabilitation

Warraich, Z. & Kleim, J. A., Jan 1 2010, In : PM and R. 2, 12 SUPPL, p. S208-S219

Research output: Contribution to journalArticle

82 Scopus citations

The vermicelli and capellini handling tests: Simple quantitative measures of dexterous forepaw function in rats and mice

Tennant, K. A., Asay, A. L., Allred, R. P., Ozburn, A. R., Kleim, J. A. & Jones, T. A., Jul 2010, In : Journal of Visualized Experiments. 41, e2076.

Research output: Contribution to journalArticle

42 Scopus citations
2009

What do motor "recovery" and "compensationg" mean in patients following stroke?

Levin, M. F., Kleim, J. A. & Wolf, S. L., May 1 2009, In : Neurorehabilitation and Neural Repair. 23, 4, p. 313-319 7 p.

Research output: Contribution to journalArticle

425 Scopus citations
2007

A novel phosphodiesterase type 4 inhibitor, HT-0712, enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia

MacDonald, E., Van Der Lee, H., Pocock, D., Cole, C., Thomas, N., VandenBerg, P. M., Bourtchouladze, R. & Kleim, J. A., Nov 1 2007, In : Neurorehabilitation and Neural Repair. 21, 6, p. 486-496 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Induction of neocortical long-term depression results in smaller movement representations, fewer excitatory perforated synapses, and more inhibitory synapses

Teskey, G. C., Young, N. A., Van Rooyen, F., Larson, S. E. M., Flynn, C., Monfils, M. H., Kleim, J. A., Henry, L. C. & Goertzen, C. D., Feb 1 2007, In : Cerebral Cortex. 17, 2, p. 434-442 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Motor learning induces astrocytic hypertrophy in the cerebellar cortex

Kleim, J. A., Markham, J. A., Vij, K., Freese, J. L., Ballard, D. H. & Greenough, W. T., Mar 28 2007, In : Behavioural Brain Research. 178, 2, p. 244-249 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

Systematic assessment of training-induced changes in corticospinal output to hand using frameless stereotaxic transcranial magnetic stimulation

Kleim, J. A., Kleim, E. D. & Cramer, S. C., Jun 28 2007, In : Nature protocols. 2, 7, p. 1675-1684 10 p.

Research output: Contribution to journalArticle

63 Scopus citations
2006

BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex

Kleim, J. A., Chan, S., Pringle, E., Schallert, K., Procaccio, V., Jimenez, R. & Cramer, S. C., Jun 16 2006, In : Nature Neuroscience. 9, 6, p. 735-737 3 p.

Research output: Contribution to journalArticle

367 Scopus citations

Experience-dependent amelioration of motor impairments in adulthood following neonatal medial frontal cortex injury in rats is accompanied by motor map expansion

Williams, P. T. J., Gharbawie, O. A., Kolb, B. & Kleim, J. A., Aug 1 2006, In : Neuroscience. 141, 3, p. 1315-1326 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

FGF-2-induced cell proliferation stimulates anatomical neurophysiological and functional recovery from neonatal motor cortex injury

Monfils, M. H., Driscoll, I., Kamitakahara, H., Wilson, B., Flynn, C., Teskey, G. C., Kleim, J. A. & Kolb, B., Aug 1 2006, In : European Journal of Neuroscience. 24, 3, p. 739-749 11 p.

Research output: Contribution to journalArticle

42 Scopus citations
2005

A quantitative comparison of synaptic density following perfusion versus immersion fixation in the rat cerebral cortex

Monfils, M. H., Bray, D. F., Driscoll, I., Kleim, J. A. & Kolb, B., Aug 15 2005, In : Microscopy Research and Technique. 67, 6, p. 300-304 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Basic fibroblast growth factor stimulates functional recovery after neonatal lesions of motor cortex in rats

Monfils, M. H., Driscoll, I., Vandenberg, P. M., Thomas, N. J., Danka, D., Kleim, J. A. & Kolb, B., Jul 19 2005, In : Neuroscience. 134, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
39 Scopus citations

Middle cerebral artery (MCA) stroke produces dysfunction in adjacent motor cortex as detected by intracortical microstimulation in rats

Gharbawie, O. A., Gonzalez, C. L. R., Williams, P. T., Kleim, J. A. & Whishaw, I. Q., Jan 1 2005, In : Neuroscience. 130, 3, p. 601-610 10 p.

Research output: Contribution to journalArticle

45 Scopus citations
2004

Cortical Synaptogenesis and Motor Map Reorganization Occur during Late, but Not Early, Phase of Motor Skill Learning

Kleim, J. A., Hogg, T. M., VandenBerg, P. M., Cooper, N. R., Bruneau, R. & Remple, M., Jan 21 2004, In : Journal of Neuroscience. 24, 3, p. 628-633 6 p.

Research output: Contribution to journalArticle

395 Scopus citations

Differential neuroplastic changes in neocortical movement representations and dendritic morphology in epilepsy-prone and epilepsy-resistant rat strains following high-frequency stimulation

Flynn, C., Monfils, M. H., Kleim, J. A., Kolb, B., McIntyre, D. C. & Teskey, G. C., Apr 1 2004, In : European Journal of Neuroscience. 19, 8, p. 2319-2328 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Evidence for bilateral control of skilled movements: Ipsilateral skilled forelimb reaching deficits and functional recovery in rats follow motor cortex and lateral frontal cortex lesions

Gonzalez, C. L. R., Gharbawie, O. A., Williams, P. T., Kleim, J. A., Kolb, B. & Whishaw, I. Q., Dec 1 2004, In : European Journal of Neuroscience. 20, 12, p. 3442-3452 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Long-term Potentiation Induces Expanded Movement Representations and Dendritic Hypertrophy in Layer V of Rat Sensorimotor Neocortex

Monfils, M. H., VandenBerg, P. M., Kleim, J. A. & Teskey, G. C., May 1 2004, In : Cerebral Cortex. 14, 5, p. 586-593 8 p.

Research output: Contribution to journalArticle

103 Scopus citations

Preserved ipsilateral-to-lesion motor map organization in the unilateral 6-OHDA-treated rat model of Parkinson's disease

Metz, G. A., Piecharka, D. M., Kleim, J. A. & Whishaw, I. Q., Nov 5 2004, In : Brain Research. 1026, 1, p. 126-135 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2003

Functional organization of adult motor cortex is dependent upon continued protein synthesis

Kleim, J. A., Bruneau, R., Calder, K., Pocock, D., VandenBerg, P. M., MacDonald, E., Monfils, M. H., Sutherland, R. J. & Nader, K., Sep 25 2003, In : Neuron. 40, 1, p. 167-176 10 p.

Research output: Contribution to journalArticle

113 Scopus citations
58 Scopus citations
2002

A brain adaptation view of plasticity: Is synaptic plasticity an overly limited concept?

Grossman, A. W., Churchill, J. D., Bates, K. E., Kleim, J. A. & Greenough, W. T., Jan 1 2002, In : Progress in brain research. 138, p. 91-108 18 p.

Research output: Contribution to journalArticle

54 Scopus citations

Exercise induces angiogenesis but does not alter movement representations within rat motor cortex

Kleim, J. A., Cooper, N. R. & VandenBerg, P. M., Apr 26 2002, In : Brain Research. 934, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

211 Scopus citations

Learning-induced multiple synapse formation in rat cerebellar cortex

Federmeier, K. D., Kleim, J. A. & Greenough, W. T., Nov 8 2002, In : Neuroscience Letters. 332, 3, p. 180-184 5 p.

Research output: Contribution to journalArticle

62 Scopus citations
39 Scopus citations

Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex

Kleim, J. A., Barbay, S., Cooper, N. R., Hogg, T. M., Reidel, C. N., Remple, M. S. & Nudo, R. J., Jan 1 2002, In : Neurobiology of Learning and Memory. 77, 1, p. 63-77 15 p.

Research output: Contribution to journalArticle

354 Scopus citations

Motor map expansion following repeated cortical and limbic seizures is related to synaptic potentiation

Campbell Teskey, G., Monfils, M. H., Vandenberg, P. M. & Kleim, J. A., Jan 1 2002, In : Cerebral Cortex. 12, 1, p. 98-105 8 p.

Research output: Contribution to journalArticle

83 Scopus citations