XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity

Linda C. Johansson, Benjamin Stauch, John D. McCorvy, Gye Won Han, Nilkanth Patel, Xi Ping Huang, Alexander Batyuk, Cornelius Gati, Samuel T. Slocum, Chufeng Li, Jessica M. Grandner, Shuming Hao, Reid H.J. Olsen, Alexandra R. Tribo, Sahba Zaare, Lan Zhu, Nadia Zatsepin, Uwe Weierstall, Saïd Yous, Raymond C. StevensWei Liu, Bryan L. Roth, Vsevolod Katritch, Vadim Cherezov

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Search results

  • XFEL crystal structure of human melatonin receptor MT2 in complex with ramelteon

    Johansson, L. C. (Contributor), Stauch, B. (Contributor), McCorvy, J. D. (Contributor), Han, G. W. (Contributor), Patel, N. (Contributor), Huang, X. (Contributor), Batyuk, A. (Contributor), Gati, C. (Contributor), Slocum, S. T. (Contributor), Li, C. (Contributor), Grandner, J. M. (Contributor), Hao, S. (Contributor), Olsen, R. H. J. (Contributor), Tribo, A. R. (Contributor), Zaare, S. (Contributor), Zhu, L. (Contributor), Zatsepin, N. A. (Contributor), Weierstall, U. (Contributor), Yous, S. (Contributor), Stevens, R. C. (Contributor), Liu, W. (Contributor), Roth, B. L. (Contributor), Katritch, V. (Contributor) & Cherezov, V. (Contributor), Protein Data Bank (PDB), Apr 24 2019

    DOI: 10.2210/pdb6ME9, https://www.wwpdb.org/pdb?id=pdb_00006me9

    Dataset

  • XFEL crystal structure of human melatonin receptor MT2 in complex with 2-phenylmelatonin

    Johansson, L. C. (Contributor), Stauch, B. (Contributor), McCorvy, J. D. (Contributor), Han, G. W. (Contributor), Patel, N. (Contributor), Huang, X. (Contributor), Batyuk, A. (Contributor), Gati, C. (Contributor), Slocum, S. T. (Contributor), Li, C. (Contributor), Grandner, J. M. (Contributor), Hao, S. (Contributor), Olsen, R. H. J. (Contributor), Tribo, A. R. (Contributor), Zaare, S. (Contributor), Zhu, L. (Contributor), Zatsepin, N. A. (Contributor), Weierstall, U. (Contributor), Yous, S. (Contributor), Stevens, R. C. (Contributor), Liu, W. (Contributor), Roth, B. L. (Contributor), Katritch, V. (Contributor) & Cherezov, V. (Contributor), Protein Data Bank (PDB), Apr 24 2019

    DOI: 10.2210/pdb6ME6, https://www.wwpdb.org/pdb?id=pdb_00006me6

    Dataset

  • XFEL crystal structure of human melatonin receptor MT2 (N86D) in complex with 2-phenylmelatonin

    Johansson, L. C. (Contributor), Stauch, B. (Contributor), McCorvy, J. D. (Contributor), Han, G. W. (Contributor), Patel, N. (Contributor), Huang, X. (Contributor), Batyuk, A. (Contributor), Gati, C. (Contributor), Slocum, S. T. (Contributor), Li, C. (Contributor), Grandner, J. M. (Contributor), Hao, S. (Contributor), Olsen, R. H. J. (Contributor), Tribo, A. R. (Contributor), Zaare, S. (Contributor), Zhu, L. (Contributor), Zatsepin, N. A. (Contributor), Weierstall, U. (Contributor), Yous, S. (Contributor), Stevens, R. C. (Contributor), Liu, W. (Contributor), Roth, B. L. (Contributor), Katritch, V. (Contributor) & Cherezov, V. (Contributor), Protein Data Bank (PDB), Apr 24 2019

    DOI: 10.2210/pdb6ME8, https://www.wwpdb.org/pdb?id=pdb_00006me8

    Dataset

  • XFEL crystal structure of human melatonin receptor MT2 (H208A) in complex with 2-phenylmelatonin

    Johansson, L. C. (Contributor), Stauch, B. (Contributor), McCorvy, J. D. (Contributor), Han, G. W. (Contributor), Patel, N. (Contributor), Huang, X. (Contributor), Batyuk, A. (Contributor), Gati, C. (Contributor), Slocum, S. T. (Contributor), Li, C. (Contributor), Grandner, J. M. (Contributor), Hao, S. (Contributor), Olsen, R. H. J. (Contributor), Tribo, A. R. (Contributor), Zaare, S. (Contributor), Zhu, L. (Contributor), Zatsepin, N. A. (Contributor), Weierstall, U. (Contributor), Yous, S. (Contributor), Stevens, R. C. (Contributor), Liu, W. (Contributor), Roth, B. L. (Contributor), Katritch, V. (Contributor) & Cherezov, V. (Contributor), Protein Data Bank (PDB), Apr 24 2019

    DOI: 10.2210/pdb6ME7, https://www.wwpdb.org/pdb?id=pdb_00006me7

    Dataset