TY - JOUR
T1 - When good vaccines go wild
T2 - Feral Orthopoxvirus in developing countries and beyond.
AU - Moussatché, Nissin
AU - Damaso, Clarissa R.
AU - McFadden, Grant
PY - 2008
Y1 - 2008
N2 - The presence of zoonotic poxviruses in nature represents a potential human health risk that has to be re-evaluated by health authorities not only in developing countries, but also in many developed countries. For example, buffalopox virus infection remains to be a threat to humans and cattle in India, and monkeypox virus infection persists in several inhabited places in Africa and, more recently, in the USA. There are also a great number of zoonotic transmissions of cowpox virus from cats to humans in Europe. For almost a decade in Brazil, vaccinia-like viruses have been isolated from human and cattle infections. This review examines the ability of potentially pathogenic orthopoxviruses, including feral versions of vaccinia virus vaccine, to persist in nature and re-emerge for reasons we do not yet understand.
AB - The presence of zoonotic poxviruses in nature represents a potential human health risk that has to be re-evaluated by health authorities not only in developing countries, but also in many developed countries. For example, buffalopox virus infection remains to be a threat to humans and cattle in India, and monkeypox virus infection persists in several inhabited places in Africa and, more recently, in the USA. There are also a great number of zoonotic transmissions of cowpox virus from cats to humans in Europe. For almost a decade in Brazil, vaccinia-like viruses have been isolated from human and cattle infections. This review examines the ability of potentially pathogenic orthopoxviruses, including feral versions of vaccinia virus vaccine, to persist in nature and re-emerge for reasons we do not yet understand.
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U2 - 10.3855/jidc.258
DO - 10.3855/jidc.258
M3 - Review article
C2 - 19738346
AN - SCOPUS:67650700335
SN - 1972-2680
VL - 2
SP - 156
EP - 173
JO - Journal of infection in developing countries
JF - Journal of infection in developing countries
IS - 3
ER -