What makes a natural clay antibacterial?

Lynda Williams, David W. Metge, Dennis D. Eberl, Ronald W. Harvey, Amanda G. Turner, Panjai Prapaipong, Amisha T. Poret-Peterson

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Natural clays have been used in ancient and modern medicine, but the mechanism(s) that make certain clays lethal against bacterial pathogens has not been identified. We have compared the depositional environments, mineralogies, and chemistries of clays that exhibit antibacterial effects on a broad spectrum of human pathogens including antibiotic resistant strains. Natural antibacterial clays contain nanoscale (2+ solubility.Chemical analyses of E. coli killed by aqueous leachates of an antibacterial clay show that intracellular concentrations of Fe and P are elevated relative to controls. Phosphorus uptake by the cells supports a regulatory role of polyphosphate or phospholipids in controlling Fe 2+. Fenton reaction products can degrade critical cell components, but we deduce that extracellular processes do not cause cell death. Rather, Fe2+ overwhelms outer membrane regulatory proteins and is oxidized when it enters the cell, precipitating Fe3+ and producing lethal hydroxyl radicals.

Original languageEnglish (US)
Pages (from-to)3768-3773
Number of pages6
JournalEnvironmental Science and Technology
Volume45
Issue number8
DOIs
StatePublished - Apr 15 2011

Fingerprint

clay
Pathogens
pathogen
Polyphosphates
Cell death
hydroxyl radical
phospholipid
Reaction products
Hydroxyl Radical
antibiotics
medicine
depositional environment
Phosphorus
Escherichia coli
Medicine
leachate
Phospholipids
solubility
Solubility
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry

Cite this

Williams, L., Metge, D. W., Eberl, D. D., Harvey, R. W., Turner, A. G., Prapaipong, P., & Poret-Peterson, A. T. (2011). What makes a natural clay antibacterial? Environmental Science and Technology, 45(8), 3768-3773. https://doi.org/10.1021/es1040688

What makes a natural clay antibacterial? / Williams, Lynda; Metge, David W.; Eberl, Dennis D.; Harvey, Ronald W.; Turner, Amanda G.; Prapaipong, Panjai; Poret-Peterson, Amisha T.

In: Environmental Science and Technology, Vol. 45, No. 8, 15.04.2011, p. 3768-3773.

Research output: Contribution to journalArticle

Williams, L, Metge, DW, Eberl, DD, Harvey, RW, Turner, AG, Prapaipong, P & Poret-Peterson, AT 2011, 'What makes a natural clay antibacterial?', Environmental Science and Technology, vol. 45, no. 8, pp. 3768-3773. https://doi.org/10.1021/es1040688
Williams L, Metge DW, Eberl DD, Harvey RW, Turner AG, Prapaipong P et al. What makes a natural clay antibacterial? Environmental Science and Technology. 2011 Apr 15;45(8):3768-3773. https://doi.org/10.1021/es1040688
Williams, Lynda ; Metge, David W. ; Eberl, Dennis D. ; Harvey, Ronald W. ; Turner, Amanda G. ; Prapaipong, Panjai ; Poret-Peterson, Amisha T. / What makes a natural clay antibacterial?. In: Environmental Science and Technology. 2011 ; Vol. 45, No. 8. pp. 3768-3773.
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