What is the functional significance of chronic stress-induced CA3 dendritic retraction within the hippocampus?

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Chronic stress produces consistent and reversible changes within the dendritic arbors of CA3 hippocampal neurons, characterized by decreased dendritic length and reduced branch number. This chronic stress-induced dendritic retraction has traditionally corresponded to hippocampus-dependent spatial memory deficits. However, anomalous findings have raised doubts as to whether a CA3 dendritic retraction is sufficient to compromise hippocampal function. The purpose of this review is to outline the mechanism underlying chronic stress-induced CA3 dendritic retraction and to explain why CA3 dendritic retraction has been thought to mediate spatial memory. The anomalous findings provide support for a modified hypothesis, in which chronic stress is proposed to induce CA3 dendritic retraction, which then disrupts hypothalamic-pituitary- adrenal axis activity, leading to dysregulated glucocorticoid release. The combination of hippocampal CA3 dendritic retraction and elevated glucocorticoid release contributes to impaired spatial memory. These findings are presented in the context of clinical conditions associated with elevated glucocorticoids.

Original languageEnglish (US)
Pages (from-to)41-60
Number of pages20
JournalBehavioral and Cognitive Neuroscience Reviews
Volume5
Issue number1
DOIs
StatePublished - Mar 2006

Fingerprint

Glucocorticoids
Hippocampus
Memory Disorders
Neurons
Spatial Memory

Keywords

  • Brain plasticity
  • Chronic stress
  • Hippocampus
  • Spatial memory

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience

Cite this

@article{c4b2f7fa56274759b54cd743d8f8e5c0,
title = "What is the functional significance of chronic stress-induced CA3 dendritic retraction within the hippocampus?",
abstract = "Chronic stress produces consistent and reversible changes within the dendritic arbors of CA3 hippocampal neurons, characterized by decreased dendritic length and reduced branch number. This chronic stress-induced dendritic retraction has traditionally corresponded to hippocampus-dependent spatial memory deficits. However, anomalous findings have raised doubts as to whether a CA3 dendritic retraction is sufficient to compromise hippocampal function. The purpose of this review is to outline the mechanism underlying chronic stress-induced CA3 dendritic retraction and to explain why CA3 dendritic retraction has been thought to mediate spatial memory. The anomalous findings provide support for a modified hypothesis, in which chronic stress is proposed to induce CA3 dendritic retraction, which then disrupts hypothalamic-pituitary- adrenal axis activity, leading to dysregulated glucocorticoid release. The combination of hippocampal CA3 dendritic retraction and elevated glucocorticoid release contributes to impaired spatial memory. These findings are presented in the context of clinical conditions associated with elevated glucocorticoids.",
keywords = "Brain plasticity, Chronic stress, Hippocampus, Spatial memory",
author = "Cheryl Conrad",
year = "2006",
month = "3",
doi = "10.1177/1534582306289043",
language = "English (US)",
volume = "5",
pages = "41--60",
journal = "Behavioral and Cognitive Neuroscience Reviews",
issn = "1534-5823",
publisher = "SAGE Publications Inc.",
number = "1",

}

TY - JOUR

T1 - What is the functional significance of chronic stress-induced CA3 dendritic retraction within the hippocampus?

AU - Conrad, Cheryl

PY - 2006/3

Y1 - 2006/3

N2 - Chronic stress produces consistent and reversible changes within the dendritic arbors of CA3 hippocampal neurons, characterized by decreased dendritic length and reduced branch number. This chronic stress-induced dendritic retraction has traditionally corresponded to hippocampus-dependent spatial memory deficits. However, anomalous findings have raised doubts as to whether a CA3 dendritic retraction is sufficient to compromise hippocampal function. The purpose of this review is to outline the mechanism underlying chronic stress-induced CA3 dendritic retraction and to explain why CA3 dendritic retraction has been thought to mediate spatial memory. The anomalous findings provide support for a modified hypothesis, in which chronic stress is proposed to induce CA3 dendritic retraction, which then disrupts hypothalamic-pituitary- adrenal axis activity, leading to dysregulated glucocorticoid release. The combination of hippocampal CA3 dendritic retraction and elevated glucocorticoid release contributes to impaired spatial memory. These findings are presented in the context of clinical conditions associated with elevated glucocorticoids.

AB - Chronic stress produces consistent and reversible changes within the dendritic arbors of CA3 hippocampal neurons, characterized by decreased dendritic length and reduced branch number. This chronic stress-induced dendritic retraction has traditionally corresponded to hippocampus-dependent spatial memory deficits. However, anomalous findings have raised doubts as to whether a CA3 dendritic retraction is sufficient to compromise hippocampal function. The purpose of this review is to outline the mechanism underlying chronic stress-induced CA3 dendritic retraction and to explain why CA3 dendritic retraction has been thought to mediate spatial memory. The anomalous findings provide support for a modified hypothesis, in which chronic stress is proposed to induce CA3 dendritic retraction, which then disrupts hypothalamic-pituitary- adrenal axis activity, leading to dysregulated glucocorticoid release. The combination of hippocampal CA3 dendritic retraction and elevated glucocorticoid release contributes to impaired spatial memory. These findings are presented in the context of clinical conditions associated with elevated glucocorticoids.

KW - Brain plasticity

KW - Chronic stress

KW - Hippocampus

KW - Spatial memory

UR - http://www.scopus.com/inward/record.url?scp=33745625840&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745625840&partnerID=8YFLogxK

U2 - 10.1177/1534582306289043

DO - 10.1177/1534582306289043

M3 - Article

VL - 5

SP - 41

EP - 60

JO - Behavioral and Cognitive Neuroscience Reviews

JF - Behavioral and Cognitive Neuroscience Reviews

SN - 1534-5823

IS - 1

ER -