Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease

Peter E. Lipsky, Peter Brooks, Leslie J. Crofford, Raymond DuBois, David Graham, Lee S. Simon, Leo B.A. Van De Putte, Steven B. Abramson

Research output: Contribution to journalReview article

148 Scopus citations

Abstract

Originally suggested to function mainly in inflammatory situations, recent data have implied important roles for the cyclooxygenase-2 isoenzyme in reproductive biologic processes, renal and neurologic function, and the antithrombotic activities of endothelial cells. As cyclooxygenase-2-specific inhibitors have recently become available as analgesic and anti-inflammatory drugs, a comprehensive view of this rapidly evolving field is necessary to anticipate both the potential therapeutic benefits and toxic effects associated with these agents.

Original languageEnglish (US)
Pages (from-to)913-920
Number of pages8
JournalArchives of Internal Medicine
Volume160
Issue number7
DOIs
StatePublished - Apr 10 2000

ASJC Scopus subject areas

  • Internal Medicine

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    Lipsky, P. E., Brooks, P., Crofford, L. J., DuBois, R., Graham, D., Simon, L. S., Van De Putte, L. B. A., & Abramson, S. B. (2000). Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease. Archives of Internal Medicine, 160(7), 913-920. https://doi.org/10.1001/archinte.160.7.913