Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease

Peter E. Lipsky; Peter Brooks; Leslie J. Crofford; Raymond DuBois; David Graham; Lee S. Simon; Leo B.A. Van De Putte; Steven B. Abramson

doi:10.1001/archinte.160.7.913

Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease

Peter E. Lipsky, Peter Brooks, Leslie J. Crofford, Raymond DuBois, David Graham, Lee S. Simon, Leo B.A. Van De Putte, Steven B. Abramson

Research output: Contribution to journal › Review article › peer-review

158 Scopus citations

Abstract

Originally suggested to function mainly in inflammatory situations, recent data have implied important roles for the cyclooxygenase-2 isoenzyme in reproductive biologic processes, renal and neurologic function, and the antithrombotic activities of endothelial cells. As cyclooxygenase-2-specific inhibitors have recently become available as analgesic and anti-inflammatory drugs, a comprehensive view of this rapidly evolving field is necessary to anticipate both the potential therapeutic benefits and toxic effects associated with these agents.

Original language	English (US)
Pages (from-to)	913-920
Number of pages	8
Journal	Archives of Internal Medicine
Volume	160
Issue number	7
DOIs	https://doi.org/10.1001/archinte.160.7.913
State	Published - Apr 10 2000
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine

Access to Document

10.1001/archinte.160.7.913

Cite this

@article{7d8047fbf6294bcdbfe4347e34f81a55,

title = "Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease",

abstract = "Originally suggested to function mainly in inflammatory situations, recent data have implied important roles for the cyclooxygenase-2 isoenzyme in reproductive biologic processes, renal and neurologic function, and the antithrombotic activities of endothelial cells. As cyclooxygenase-2-specific inhibitors have recently become available as analgesic and anti-inflammatory drugs, a comprehensive view of this rapidly evolving field is necessary to anticipate both the potential therapeutic benefits and toxic effects associated with these agents.",

author = "Lipsky, {Peter E.} and Peter Brooks and Crofford, {Leslie J.} and Raymond DuBois and David Graham and Simon, {Lee S.} and {Van De Putte}, {Leo B.A.} and Abramson, {Steven B.}",

year = "2000",

month = apr,

day = "10",

doi = "10.1001/archinte.160.7.913",

language = "English (US)",

volume = "160",

pages = "913--920",

journal = "Archives of Internal Medicine",

issn = "0003-9926",

publisher = "American Medical Association",

number = "7",

}

TY - JOUR

T1 - Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease

AU - Lipsky, Peter E.

AU - Brooks, Peter

AU - Crofford, Leslie J.

AU - DuBois, Raymond

AU - Graham, David

AU - Simon, Lee S.

AU - Van De Putte, Leo B.A.

AU - Abramson, Steven B.

PY - 2000/4/10

Y1 - 2000/4/10

N2 - Originally suggested to function mainly in inflammatory situations, recent data have implied important roles for the cyclooxygenase-2 isoenzyme in reproductive biologic processes, renal and neurologic function, and the antithrombotic activities of endothelial cells. As cyclooxygenase-2-specific inhibitors have recently become available as analgesic and anti-inflammatory drugs, a comprehensive view of this rapidly evolving field is necessary to anticipate both the potential therapeutic benefits and toxic effects associated with these agents.

AB - Originally suggested to function mainly in inflammatory situations, recent data have implied important roles for the cyclooxygenase-2 isoenzyme in reproductive biologic processes, renal and neurologic function, and the antithrombotic activities of endothelial cells. As cyclooxygenase-2-specific inhibitors have recently become available as analgesic and anti-inflammatory drugs, a comprehensive view of this rapidly evolving field is necessary to anticipate both the potential therapeutic benefits and toxic effects associated with these agents.

UR - http://www.scopus.com/inward/record.url?scp=0034630270&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034630270&partnerID=8YFLogxK

U2 - 10.1001/archinte.160.7.913

DO - 10.1001/archinte.160.7.913

M3 - Review article

C2 - 10761955

AN - SCOPUS:0034630270

SN - 0003-9926

VL - 160

SP - 913

EP - 920

JO - Archives of Internal Medicine

JF - Archives of Internal Medicine

IS - 7

ER -

Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this