Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease

Peter E. Lipsky, Peter Brooks, Leslie J. Crofford, Raymond DuBois, David Graham, Lee S. Simon, Leo B.A. Van De Putte, Steven B. Abramson

    Research output: Contribution to journalReview articlepeer-review

    149 Scopus citations

    Abstract

    Originally suggested to function mainly in inflammatory situations, recent data have implied important roles for the cyclooxygenase-2 isoenzyme in reproductive biologic processes, renal and neurologic function, and the antithrombotic activities of endothelial cells. As cyclooxygenase-2-specific inhibitors have recently become available as analgesic and anti-inflammatory drugs, a comprehensive view of this rapidly evolving field is necessary to anticipate both the potential therapeutic benefits and toxic effects associated with these agents.

    Original languageEnglish (US)
    Pages (from-to)913-920
    Number of pages8
    JournalArchives of Internal Medicine
    Volume160
    Issue number7
    DOIs
    StatePublished - Apr 10 2000

    ASJC Scopus subject areas

    • Internal Medicine

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