TY - JOUR
T1 - Unmet clinical need in autoimmune liver diseases
AU - Dyson, Jessica K.
AU - Webb, Gwilym
AU - Hirschfield, Gideon M.
AU - Lohse, Ansgar
AU - Beuers, Ulrich
AU - Lindor, Keith
AU - Jones, David E J
N1 - Funding Information:
The UK-PBC Research Consortium is funded by the Medical Research Council and works with, and receives funding from, industrial partners working in the area of therapy in PBC, including Intercept and Lumena.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Summary Despite recent advances in understanding and treatment, there remain significant areas of unmet clinical need in each of the autoimmune liver diseases (AILDs). The evolving research landscape and emerging large patient cohorts are creating unique opportunities to translate science into new therapies and care pathways, with the potential to significantly improve the lives of AILD patients. However, the areas of unmet need represent real challenges, which need to be addressed, if this vision is to be realised. This review describes the areas of unmet need in AILD in adults relating to diagnostic and prognostic assessment, primary therapy, symptom management, trial design and delivery, and structured care delivery, with the aim of focusing future research prioritisation.
AB - Summary Despite recent advances in understanding and treatment, there remain significant areas of unmet clinical need in each of the autoimmune liver diseases (AILDs). The evolving research landscape and emerging large patient cohorts are creating unique opportunities to translate science into new therapies and care pathways, with the potential to significantly improve the lives of AILD patients. However, the areas of unmet need represent real challenges, which need to be addressed, if this vision is to be realised. This review describes the areas of unmet need in AILD in adults relating to diagnostic and prognostic assessment, primary therapy, symptom management, trial design and delivery, and structured care delivery, with the aim of focusing future research prioritisation.
KW - Autoimmune hepatitis
KW - Autoimmune liver diseases
KW - IgG4 disease
KW - Primary biliary cirrhosis
KW - Primary sclerosing cholangitis
KW - Stratified care delivery
KW - Unmet clinical need
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U2 - 10.1016/j.jhep.2014.09.010
DO - 10.1016/j.jhep.2014.09.010
M3 - Review article
C2 - 25234946
AN - SCOPUS:84918787307
SN - 0168-8278
VL - 62
SP - 208
EP - 218
JO - Journal of Hepatology
JF - Journal of Hepatology
IS - 1
ER -