Unmet clinical need in autoimmune liver diseases

Jessica K. Dyson, Gwilym Webb, Gideon M. Hirschfield, Ansgar Lohse, Ulrich Beuers, Keith Lindor, David E J Jones

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Summary Despite recent advances in understanding and treatment, there remain significant areas of unmet clinical need in each of the autoimmune liver diseases (AILDs). The evolving research landscape and emerging large patient cohorts are creating unique opportunities to translate science into new therapies and care pathways, with the potential to significantly improve the lives of AILD patients. However, the areas of unmet need represent real challenges, which need to be addressed, if this vision is to be realised. This review describes the areas of unmet need in AILD in adults relating to diagnostic and prognostic assessment, primary therapy, symptom management, trial design and delivery, and structured care delivery, with the aim of focusing future research prioritisation.

Original languageEnglish (US)
Pages (from-to)208-218
Number of pages11
JournalJournal of Hepatology
Volume62
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • Autoimmune hepatitis
  • Autoimmune liver diseases
  • IgG4 disease
  • Primary biliary cirrhosis
  • Primary sclerosing cholangitis
  • Stratified care delivery
  • Unmet clinical need

ASJC Scopus subject areas

  • Hepatology

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    Dyson, J. K., Webb, G., Hirschfield, G. M., Lohse, A., Beuers, U., Lindor, K., & Jones, D. E. J. (2015). Unmet clinical need in autoimmune liver diseases. Journal of Hepatology, 62(1), 208-218. https://doi.org/10.1016/j.jhep.2014.09.010