Understanding the global properties of functionally-related gene networks using the gene ontology

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

The global behavior of interactions between genes can be investigated by forming the network of functionally-related genes using the annotations based on the Gene Ontology. We define two genes to be connected when the pair of genes is involved in the same biological process. There has been other work on the analysis of different kinds of cellular and metabolic networks, such as gene coexpression network, in which genes are paired when they are found to be coexpressed in the microarray experiments. We observe that our functionally-related gene networks among humans, fruit flies, worms and yeast exhibit the small-world property, but all except the network of worms show the existence of the scale-free property.

Original languageEnglish (US)
Title of host publicationProceedings of the Pacific Symposium on Biocomputing 2005, PSB 2005
Pages209-220
Number of pages12
StatePublished - Dec 1 2005
Event10th Pacific Symposium on Biocomputing, PSB 2005 - Big Island of Hawaii, United States
Duration: Jan 4 2005Jan 8 2005

Publication series

NameProceedings of the Pacific Symposium on Biocomputing 2005, PSB 2005

Other

Other10th Pacific Symposium on Biocomputing, PSB 2005
CountryUnited States
CityBig Island of Hawaii
Period1/4/051/8/05

ASJC Scopus subject areas

  • Computational Theory and Mathematics
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Understanding the global properties of functionally-related gene networks using the gene ontology'. Together they form a unique fingerprint.

Cite this