Understanding the global properties of functionally-related gene networks using the gene ontology

L. Tari; Chitta Baral; Partha Dasgupta

Understanding the global properties of functionally-related gene networks using the gene ontology

L. Tari, Chitta Baral, Partha Dasgupta

Computer Science and Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

10 Scopus citations

Abstract

The global behavior of interactions between genes can be investigated by forming the network of functionally-related genes using the annotations based on the Gene Ontology. We define two genes to be connected when the pair of genes is involved in the same biological process. There has been other work on the analysis of different kinds of cellular and metabolic networks, such as gene coexpression network, in which genes are paired when they are found to be coexpressed in the microarray experiments. We observe that our functionally-related gene networks among humans, fruit flies, worms and yeast exhibit the small-world property, but all except the network of worms show the existence of the scale-free property.

Original language	English (US)
Title of host publication	Proceedings of the Pacific Symposium on Biocomputing 2005, PSB 2005
Pages	209-220
Number of pages	12
State	Published - 2005
Event	10th Pacific Symposium on Biocomputing, PSB 2005 - Big Island of Hawaii, United States Duration: Jan 4 2005 → Jan 8 2005

Publication series

Name	Proceedings of the Pacific Symposium on Biocomputing 2005, PSB 2005

Other

Other	10th Pacific Symposium on Biocomputing, PSB 2005
Country/Territory	United States
City	Big Island of Hawaii
Period	1/4/05 → 1/8/05

ASJC Scopus subject areas

Computational Theory and Mathematics
Biomedical Engineering

Cite this

Understanding the global properties of functionally-related gene networks using the gene ontology. / Tari, L.; Baral, Chitta; Dasgupta, Partha.
Proceedings of the Pacific Symposium on Biocomputing 2005, PSB 2005. 2005. p. 209-220 (Proceedings of the Pacific Symposium on Biocomputing 2005, PSB 2005).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Tari, L, Baral, C & Dasgupta, P 2005, Understanding the global properties of functionally-related gene networks using the gene ontology. in Proceedings of the Pacific Symposium on Biocomputing 2005, PSB 2005. Proceedings of the Pacific Symposium on Biocomputing 2005, PSB 2005, pp. 209-220, 10th Pacific Symposium on Biocomputing, PSB 2005, Big Island of Hawaii, United States, 1/4/05.

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BT - Proceedings of the Pacific Symposium on Biocomputing 2005, PSB 2005

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ER -

Understanding the global properties of functionally-related gene networks using the gene ontology

Abstract

Publication series

Other

ASJC Scopus subject areas

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