Ultrastructural comparison of morphogenesis and fate of Marek's disease and infectious laryngotracheitis viruses in chicken kidney cells

W. C. Davis, J. M. Sharma

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The intracellular location and morphogenesis of infectious laryngotracheitis virus (LTV), a group A herpesvirus, and 2 isolates of Marek's disease virus (MDV), a group B herpesvirus, were compared to obtain information on the ultrastructural basis of cell association of MDV. Subsequent to their initial appearance in the nucleus, laryngotracheitis (LT) and Marek's disease (MD) nucleocapsids were seen in the cytoplasm in association with a reticulum of tubules similar in morphologic features to the endoplasmic reticulum. The predominant site of envelopment was intracytoplasmic for LTV and intranuclear for MDV. Enveloped LT virions accumulated in the cytoplasmic vacuoles and were released singly from the cell membrane. The MD virions seemed to undergo degradation in the cytoplasm. It is proposed that cytoplasmic degradation of MD virions may account for their failure to be released in cell culture.

Original languageEnglish (US)
Pages (from-to)873-880
Number of pages8
JournalAmerican journal of veterinary research
Issue number7
StatePublished - Dec 1 1973


ASJC Scopus subject areas

  • veterinary(all)

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