Ultrastructural comparison of morphogenesis and fate of Marek's disease and infectious laryngotracheitis viruses in chicken kidney cells

W. C. Davis, J. M. Sharma

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The intracellular location and morphogenesis of infectious laryngotracheitis virus (LTV), a group A herpesvirus, and 2 isolates of Marek's disease virus (MDV), a group B herpesvirus, were compared to obtain information on the ultrastructural basis of cell association of MDV. Subsequent to their initial appearance in the nucleus, laryngotracheitis (LT) and Marek's disease (MD) nucleocapsids were seen in the cytoplasm in association with a reticulum of tubules similar in morphologic features to the endoplasmic reticulum. The predominant site of envelopment was intracytoplasmic for LTV and intranuclear for MDV. Enveloped LT virions accumulated in the cytoplasmic vacuoles and were released singly from the cell membrane. The MD virions seemed to undergo degradation in the cytoplasm. It is proposed that cytoplasmic degradation of MD virions may account for their failure to be released in cell culture.

Original languageEnglish (US)
Pages (from-to)873-880
Number of pages8
JournalAmerican Journal of Veterinary Research
Volume34
Issue number7
StatePublished - 1973
Externally publishedYes

Fingerprint

Gallid herpesvirus 1
Marek Disease
Mardivirus
Marek disease
kidney cells
Morphogenesis
virion
morphogenesis
Chickens
chickens
Viruses
Kidney
Virion
cytoplasm
Macacine herpesvirus 1
nucleocapsid
reticulum
degradation
Gallid Herpesvirus 3
Cytoplasm

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Ultrastructural comparison of morphogenesis and fate of Marek's disease and infectious laryngotracheitis viruses in chicken kidney cells. / Davis, W. C.; Sharma, J. M.

In: American Journal of Veterinary Research, Vol. 34, No. 7, 1973, p. 873-880.

Research output: Contribution to journalArticle

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