Tyrosine hydroxylase-immunoreactive somata within the primate subfornical organ: species specificity

Jeffrey H. Kordower, John R. Sladek, Massimo S. Fiandaca, Guoying Bing, Don M. Gash

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The present study describes a collection of tyrosine hydroxylase-immunoreactive (TH-ir) somata within the subfornical organ (SFO) of the Cebus monkey. In contrast, no cell bodies, and only sparse TH-ir fibers, were observed within the SFO in rats. In the monkey, these TH-ir neurons were observed throughout the rostrocaudal extent of the SFO, preferentially located at its lateral and dorsal aspects. These neurons were bipolar and multipolar with long, beaded, varicose fibers emanating from the cell soma. Cebus monkeys displayed dopamine beta hydroxylase and phenylethanolamine-N-methyltransferase- immunoreactive within established noradrenergic and adrenergic nuclei respectively, but not within the SFO, suggesting that the neurons which are immunoreactive for TH in this region contain dopamine.

Original languageEnglish (US)
Pages (from-to)221-229
Number of pages9
JournalBrain Research
Volume461
Issue number2
DOIs
StatePublished - Oct 4 1988
Externally publishedYes

Keywords

  • Catecholamine
  • Cebus monkey
  • Immunohistochemistry
  • Non-human primate
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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