Two-dimensional LNA/DNA arrays: Estimating the helicity of LNA/DNA hybrid duplex

Sherri Rinker, Yan Liu, Hao Yan

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


We measured the helical repeats of a non-natural nucleic acid, locked nucleic acid (LNA), by incorporating LNA strands into the outer arms of a DNA double crossover (DX) molecule; atomic force microscopy (AFM) imaging of the two-dimensional (2D) arrays self-assembled from these DX molecules allows us to derive the helical repeat of the LNA/DNA hetero-duplex to be 13.2 ± 0.9 base pairs per turn.

Original languageEnglish (US)
Pages (from-to)2675-2677
Number of pages3
JournalChemical Communications
Issue number25
StatePublished - 2006

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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