Tumour immunotherapy: New tools, new treatment modalities and new T-cell antigens

J. L. Schultze, B. Maecker, M. S. Von Bergwelt-Baildon, K. S. Anderson, R. H. Vonderheide

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Tumour immunology has seen many exciting developments in the last few years. In addition to tumour antigens that are defined by antitumour T- and B-cell responses in patients, the human telomerase reverse transcriptase has been identified by 'reverse immunology' as the first truly universal tumour antigen. Molecular remission has been associated with a cancer vaccine that targets the clonal idiotype of B-cell malignancies, and sophisticated cellular vaccines including fusions of tumour cells and antigen-presenting cells) have demonstrated promising results. Moreover, our capabilities of measuring immunity have been significantly enhanced by novel technology, such as major histocompatibility complex (MHC)-peptide tetramers and ELISPOT analysis. We are now capable of tracking antigen-specific T cells at a single cell level. This review will analyse recent developments and highlight some important issues that need to be addressed in the future.

Original languageEnglish (US)
Pages (from-to)81-89
Number of pages9
JournalVox Sanguinis
Volume80
Issue number2
DOIs
StatePublished - Feb 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

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    Schultze, J. L., Maecker, B., Von Bergwelt-Baildon, M. S., Anderson, K. S., & Vonderheide, R. H. (2001). Tumour immunotherapy: New tools, new treatment modalities and new T-cell antigens. Vox Sanguinis, 80(2), 81-89. https://doi.org/10.1046/j.1423-0410.2001.00014.x