Tubal sterilization with a waterborne polyethylene glycol in situ cross-linking material: A minimally invasive approach

Ryan McLemore, Eun Jeong Kim, Tedd A. Brandon, Gloria Aerni, Kelly H. Roy, Brent Vernon

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Objective: To assess the effectiveness and compatibility of an in situ-gelling polymeric device when implanted in the fallopian tube to prevent pregnancy. Design: Controlled laboratory study. Setting: Animals in a controlled laboratory environment. Animal(s): Ten white New Zealand rabbits (nine female and one male). Intervention(s): The material was implanted through a small incision into one of each rabbit's twin fallopian tubes. The rabbits then were allowed to heal. After a healing period of 6 to 10 weeks, the rabbits were bred. After breeding, the animals were killed, and samples were collected from their fallopian tubes for histology. Main Outcome Measure(s): Pregnancy of the specimens. Result(s): Four specimens showed unilateral pregnancy (pregnancy in only one uterus). Because rabbits have the capacity to be pregnant in both uteri simultaneously, this suggests strong potential of the material for use as a contraceptive. Conclusion(s): Although concerns remain concerning distension and potential injury resulting from use of the system, enough data have been gathered to warrant further study of this material for use in humans.

Original languageEnglish (US)
Pages (from-to)1284-1292
Number of pages9
JournalFertility and Sterility
Volume83
Issue number4 SUPPL.
DOIs
StatePublished - Apr 2005

Keywords

  • Biocompatibility
  • Cross-linking
  • Fallopian tube
  • In situ
  • Michael-type reactions
  • Sterilization
  • Water borne

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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