Transplanted dopaminergic neurons develop PD pathologic changes: A second case report

Jeffrey H. Kordower, Yaping Chu, Robert A. Hauser, C. Warren Olanow, Thomas B. Freeman

Research output: Contribution to journalArticlepeer-review

200 Scopus citations

Abstract

This report describes pathological changes within the grafted neurons of another patient with Parkinson's disease (PD) who died 14 years posttransplantation. Although numerous healthy appearing grafted neurons were present at this long-term time point, some displayed Lewy bodies as evidenced by alpha-synuclein, ubiquitin, and thioflavin-S staining. Additionally, there was a general loss of dopamine transporter-immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD-like pathology is seen in young grafted neurons when they survive long term.

Original languageEnglish (US)
Pages (from-to)2303-2306
Number of pages4
JournalMovement Disorders
Volume23
Issue number16
DOIs
StatePublished - Dec 15 2008
Externally publishedYes

Keywords

  • Lewy body
  • Substantial nigra
  • Transplantation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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