Abstract
This report describes pathological changes within the grafted neurons of another patient with Parkinson's disease (PD) who died 14 years posttransplantation. Although numerous healthy appearing grafted neurons were present at this long-term time point, some displayed Lewy bodies as evidenced by alpha-synuclein, ubiquitin, and thioflavin-S staining. Additionally, there was a general loss of dopamine transporter-immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD-like pathology is seen in young grafted neurons when they survive long term.
Original language | English (US) |
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Pages (from-to) | 2303-2306 |
Number of pages | 4 |
Journal | Movement Disorders |
Volume | 23 |
Issue number | 16 |
DOIs | |
State | Published - Dec 15 2008 |
Externally published | Yes |
Keywords
- Lewy body
- Substantial nigra
- Transplantation
ASJC Scopus subject areas
- Neurology
- Clinical Neurology