Time-dependent changes in cocaine-seeking behavior and extracellular dopamine levels in the amygdala during cocaine withdrawal

Ly T L Tran-Nguyen, Rita A. Fuchs, Greg P. Coffey, David A. Baker, Laura E. O'Dell, Janet Neisewander

Research output: Contribution to journalArticle

207 Citations (Scopus)

Abstract

Cocaine and cocaine-associated cues elicit craving in addicts and reinstate cocaine-seeking behavior in rats. Craving and cocaine-seeking behavior may be mediated by withdrawal-induced changes in dopamine (DA) neurotransmission in the amygdala. To examine whether there are concomittant changes in cocaine-seeking behavior and extracellular DA levels during withdrawal, experimental rats were trained to self-administer cocaine (0.75 mg/kg IV). After 14 daily 3-hour training sessions, animals underwent either a 1-day, 1-week, or 1-month withdrawal period. Extracellular DA levels were assessed during baseline, extinction, cue reinstatement, and cocaine (15 mg/kg IP) reinstatement of cocaine-seeking behavior (i.e., defined as the difference in nonreinforced lever presses on an active minus inactive lever). Cocaine-seeking behavior became more intense during the course of cocaine withdrawal. Additionally, basal and cocaine-induced extracellular DA levels were enhanced after the 1-month withdrawal period. We suggest that the former may reflect a persistent elevation in tonic extracellular DA levels in the amygdala, whereas the latter may reflect a persistent elevation in phasic extracellular DA levels.

Original languageEnglish (US)
Pages (from-to)48-59
Number of pages12
JournalNeuropsychopharmacology
Volume19
Issue number1
DOIs
StatePublished - 1998

Fingerprint

Amygdala
Cocaine
Dopamine
Cues
Synaptic Transmission

Keywords

  • Amygdala
  • Cocaine withdrawal
  • Cocaine-seeking behavior
  • Craving
  • Dopamine
  • Extinction
  • Reinstatement
  • Self-administration

ASJC Scopus subject areas

  • Pharmacology

Cite this

Time-dependent changes in cocaine-seeking behavior and extracellular dopamine levels in the amygdala during cocaine withdrawal. / Tran-Nguyen, Ly T L; Fuchs, Rita A.; Coffey, Greg P.; Baker, David A.; O'Dell, Laura E.; Neisewander, Janet.

In: Neuropsychopharmacology, Vol. 19, No. 1, 1998, p. 48-59.

Research output: Contribution to journalArticle

Tran-Nguyen, Ly T L ; Fuchs, Rita A. ; Coffey, Greg P. ; Baker, David A. ; O'Dell, Laura E. ; Neisewander, Janet. / Time-dependent changes in cocaine-seeking behavior and extracellular dopamine levels in the amygdala during cocaine withdrawal. In: Neuropsychopharmacology. 1998 ; Vol. 19, No. 1. pp. 48-59.
@article{4b70f6f3538a4637ace10fe1161186a9,
title = "Time-dependent changes in cocaine-seeking behavior and extracellular dopamine levels in the amygdala during cocaine withdrawal",
abstract = "Cocaine and cocaine-associated cues elicit craving in addicts and reinstate cocaine-seeking behavior in rats. Craving and cocaine-seeking behavior may be mediated by withdrawal-induced changes in dopamine (DA) neurotransmission in the amygdala. To examine whether there are concomittant changes in cocaine-seeking behavior and extracellular DA levels during withdrawal, experimental rats were trained to self-administer cocaine (0.75 mg/kg IV). After 14 daily 3-hour training sessions, animals underwent either a 1-day, 1-week, or 1-month withdrawal period. Extracellular DA levels were assessed during baseline, extinction, cue reinstatement, and cocaine (15 mg/kg IP) reinstatement of cocaine-seeking behavior (i.e., defined as the difference in nonreinforced lever presses on an active minus inactive lever). Cocaine-seeking behavior became more intense during the course of cocaine withdrawal. Additionally, basal and cocaine-induced extracellular DA levels were enhanced after the 1-month withdrawal period. We suggest that the former may reflect a persistent elevation in tonic extracellular DA levels in the amygdala, whereas the latter may reflect a persistent elevation in phasic extracellular DA levels.",
keywords = "Amygdala, Cocaine withdrawal, Cocaine-seeking behavior, Craving, Dopamine, Extinction, Reinstatement, Self-administration",
author = "Tran-Nguyen, {Ly T L} and Fuchs, {Rita A.} and Coffey, {Greg P.} and Baker, {David A.} and O'Dell, {Laura E.} and Janet Neisewander",
year = "1998",
doi = "10.1016/S0893-133X(97)00205-4",
language = "English (US)",
volume = "19",
pages = "48--59",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Time-dependent changes in cocaine-seeking behavior and extracellular dopamine levels in the amygdala during cocaine withdrawal

AU - Tran-Nguyen, Ly T L

AU - Fuchs, Rita A.

AU - Coffey, Greg P.

AU - Baker, David A.

AU - O'Dell, Laura E.

AU - Neisewander, Janet

PY - 1998

Y1 - 1998

N2 - Cocaine and cocaine-associated cues elicit craving in addicts and reinstate cocaine-seeking behavior in rats. Craving and cocaine-seeking behavior may be mediated by withdrawal-induced changes in dopamine (DA) neurotransmission in the amygdala. To examine whether there are concomittant changes in cocaine-seeking behavior and extracellular DA levels during withdrawal, experimental rats were trained to self-administer cocaine (0.75 mg/kg IV). After 14 daily 3-hour training sessions, animals underwent either a 1-day, 1-week, or 1-month withdrawal period. Extracellular DA levels were assessed during baseline, extinction, cue reinstatement, and cocaine (15 mg/kg IP) reinstatement of cocaine-seeking behavior (i.e., defined as the difference in nonreinforced lever presses on an active minus inactive lever). Cocaine-seeking behavior became more intense during the course of cocaine withdrawal. Additionally, basal and cocaine-induced extracellular DA levels were enhanced after the 1-month withdrawal period. We suggest that the former may reflect a persistent elevation in tonic extracellular DA levels in the amygdala, whereas the latter may reflect a persistent elevation in phasic extracellular DA levels.

AB - Cocaine and cocaine-associated cues elicit craving in addicts and reinstate cocaine-seeking behavior in rats. Craving and cocaine-seeking behavior may be mediated by withdrawal-induced changes in dopamine (DA) neurotransmission in the amygdala. To examine whether there are concomittant changes in cocaine-seeking behavior and extracellular DA levels during withdrawal, experimental rats were trained to self-administer cocaine (0.75 mg/kg IV). After 14 daily 3-hour training sessions, animals underwent either a 1-day, 1-week, or 1-month withdrawal period. Extracellular DA levels were assessed during baseline, extinction, cue reinstatement, and cocaine (15 mg/kg IP) reinstatement of cocaine-seeking behavior (i.e., defined as the difference in nonreinforced lever presses on an active minus inactive lever). Cocaine-seeking behavior became more intense during the course of cocaine withdrawal. Additionally, basal and cocaine-induced extracellular DA levels were enhanced after the 1-month withdrawal period. We suggest that the former may reflect a persistent elevation in tonic extracellular DA levels in the amygdala, whereas the latter may reflect a persistent elevation in phasic extracellular DA levels.

KW - Amygdala

KW - Cocaine withdrawal

KW - Cocaine-seeking behavior

KW - Craving

KW - Dopamine

KW - Extinction

KW - Reinstatement

KW - Self-administration

UR - http://www.scopus.com/inward/record.url?scp=0031780704&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031780704&partnerID=8YFLogxK

U2 - 10.1016/S0893-133X(97)00205-4

DO - 10.1016/S0893-133X(97)00205-4

M3 - Article

C2 - 9608576

AN - SCOPUS:0031780704

VL - 19

SP - 48

EP - 59

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 1

ER -