Thyroid dysfunction in primary biliary cirrhosis, primary sclerosing cholangitis and non-alcoholic fatty liver disease

Marina G. Silveira, Flavia D. Mendes, Nancy N. Diehl, Felicity T. Enders, Keith Lindor

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Background/Aims: Primary biliary cirrhosis (PBC) is frequently associated with autoimmune diseases, including thyroid disease, although it is uncertain that this association is higher than in other liver diseases. Methods: We compared the prevalence and incidence of thyroid dysfunction (TD) in a series of patients with PBC (n = 67) with patients with primary sclerosing cholangitis (PSC) (n = 79) and non-alcoholic fatty liver disease (NAFLD) (n = 97) seen in a tertiary referral centre who had previously participated in clinical trials. Results: At initial evaluation, prevalence of TD in PBC was 13% compared with 11% in PSC (P = 0.71) and 25% in NAFLD (P = 0.08). Incidence of TD was 2.9 patients per 100 person-years in PBC compared with 2.1 patients per 100 person-years in PSC (P = 0.57) and 1.8 patients per 100 person-years in non-alcoholic liver disease (P = 0.45). Older age, female gender, biochemical abnormalities and concurrent autoimmune disorders were not predictive of the development of TD. Conclusions: TD was unexpectedly as common in patients with PBC as in patients with PSC and NAFLD, yet significantly more common than expected in the general population. Further investigation of thyroid disease in PSC and NAFLD is warranted.

Original languageEnglish (US)
Pages (from-to)1094-1100
Number of pages7
JournalLiver International
Volume29
Issue number7
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Sclerosing Cholangitis
Biliary Liver Cirrhosis
Thyroid Gland
Thyroid Diseases
Liver Diseases
Incidence
Non-alcoholic Fatty Liver Disease
Tertiary Care Centers
Autoimmune Diseases
Clinical Trials
Population

Keywords

  • Autoimmune diseases
  • Autoimmune liver diseases
  • Thyroid disease

ASJC Scopus subject areas

  • Hepatology

Cite this

Thyroid dysfunction in primary biliary cirrhosis, primary sclerosing cholangitis and non-alcoholic fatty liver disease. / Silveira, Marina G.; Mendes, Flavia D.; Diehl, Nancy N.; Enders, Felicity T.; Lindor, Keith.

In: Liver International, Vol. 29, No. 7, 2009, p. 1094-1100.

Research output: Contribution to journalArticle

Silveira, Marina G. ; Mendes, Flavia D. ; Diehl, Nancy N. ; Enders, Felicity T. ; Lindor, Keith. / Thyroid dysfunction in primary biliary cirrhosis, primary sclerosing cholangitis and non-alcoholic fatty liver disease. In: Liver International. 2009 ; Vol. 29, No. 7. pp. 1094-1100.
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