Thinning faster? Age-related cortical thickness differences in adults with autism spectrum disorder

Brittany Braden, Cory Riecken

Research output: Contribution to journalArticle

Abstract

Background: Over the course of the last 30 years, autism spectrum disorder (ASD) diagnoses have increased, thus identifying a large group of aging individuals with ASD. Currently, little is known regarding how aging will affect these individual's neuroanatomy, compared to the neurotypical (NT) population. Because of the anatomical overlap of ASD-related cortical pathology and age-related cortical thinning, both following an anterior-to-posterior severity gradient, we hypothesize adults with ASD will show larger age-related cortical thinning than NT adults. Methods: We analyzed cortical measurements using available data from the multi-site Autism Brain Imaging Data Exchange I (ABIDE I; n = 282) and our own cohort of middle-age to older adults with and without ASD (n = 47) mostly available in ABIDE II (n = 35). We compared correlations between cortical measures and age in right-handed adults with ASD (n = 157) and similar NT adults (n = 172), controlling for IQ and site. Participants were 18–64 years of age (mean = 29.8 years; median = 26 years). Results: We found significant differences between diagnosis groups in the relationship between age and cortical thickness for areas of left frontal lobe (pars opercularis), temporal lobe (inferior gyrus, middle gyrus, banks of the superior temporal sulcus, and entorhinal cortex), parietal lobe (inferior gyrus), and lateral occipital lobe. For all areas, adults with ASD showed a greater negative correlation between age and cortical thickness than NT adults. Conclusion: As hypothesized, adults with ASD demonstrated exacerbated age-related cortical thinning, compared to NT adults. These differences were the largest and most extensive in the left temporal lobe. Future longitudinal work is warranted to investigate whether differences in brain age trajectories will translate to unique behavioral needs in older adults with ASD.

Original languageEnglish (US)
Pages (from-to)31-38
Number of pages8
JournalResearch in Autism Spectrum Disorders
Volume64
DOIs
StatePublished - Aug 1 2019

Fingerprint

Temporal Lobe
Autism Spectrum Disorder
Neuroanatomy
Occipital Lobe
Entorhinal Cortex
Parietal Lobe
Frontal Lobe
Autistic Disorder
Neuroimaging
Pathology
Brain
Population

Keywords

  • Aging
  • ASD
  • Autism
  • Brain
  • Cortical thickness
  • Gray matter
  • MRI
  • Temporal lobe

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Thinning faster? Age-related cortical thickness differences in adults with autism spectrum disorder. / Braden, Brittany; Riecken, Cory.

In: Research in Autism Spectrum Disorders, Vol. 64, 01.08.2019, p. 31-38.

Research output: Contribution to journalArticle

@article{108e7bb1057b4701a9a7d445ea9eb9ea,
title = "Thinning faster? Age-related cortical thickness differences in adults with autism spectrum disorder",
abstract = "Background: Over the course of the last 30 years, autism spectrum disorder (ASD) diagnoses have increased, thus identifying a large group of aging individuals with ASD. Currently, little is known regarding how aging will affect these individual's neuroanatomy, compared to the neurotypical (NT) population. Because of the anatomical overlap of ASD-related cortical pathology and age-related cortical thinning, both following an anterior-to-posterior severity gradient, we hypothesize adults with ASD will show larger age-related cortical thinning than NT adults. Methods: We analyzed cortical measurements using available data from the multi-site Autism Brain Imaging Data Exchange I (ABIDE I; n = 282) and our own cohort of middle-age to older adults with and without ASD (n = 47) mostly available in ABIDE II (n = 35). We compared correlations between cortical measures and age in right-handed adults with ASD (n = 157) and similar NT adults (n = 172), controlling for IQ and site. Participants were 18–64 years of age (mean = 29.8 years; median = 26 years). Results: We found significant differences between diagnosis groups in the relationship between age and cortical thickness for areas of left frontal lobe (pars opercularis), temporal lobe (inferior gyrus, middle gyrus, banks of the superior temporal sulcus, and entorhinal cortex), parietal lobe (inferior gyrus), and lateral occipital lobe. For all areas, adults with ASD showed a greater negative correlation between age and cortical thickness than NT adults. Conclusion: As hypothesized, adults with ASD demonstrated exacerbated age-related cortical thinning, compared to NT adults. These differences were the largest and most extensive in the left temporal lobe. Future longitudinal work is warranted to investigate whether differences in brain age trajectories will translate to unique behavioral needs in older adults with ASD.",
keywords = "Aging, ASD, Autism, Brain, Cortical thickness, Gray matter, MRI, Temporal lobe",
author = "Brittany Braden and Cory Riecken",
year = "2019",
month = "8",
day = "1",
doi = "10.1016/j.rasd.2019.03.005",
language = "English (US)",
volume = "64",
pages = "31--38",
journal = "Research in Autism Spectrum Disorders",
issn = "1750-9467",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Thinning faster? Age-related cortical thickness differences in adults with autism spectrum disorder

AU - Braden, Brittany

AU - Riecken, Cory

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Background: Over the course of the last 30 years, autism spectrum disorder (ASD) diagnoses have increased, thus identifying a large group of aging individuals with ASD. Currently, little is known regarding how aging will affect these individual's neuroanatomy, compared to the neurotypical (NT) population. Because of the anatomical overlap of ASD-related cortical pathology and age-related cortical thinning, both following an anterior-to-posterior severity gradient, we hypothesize adults with ASD will show larger age-related cortical thinning than NT adults. Methods: We analyzed cortical measurements using available data from the multi-site Autism Brain Imaging Data Exchange I (ABIDE I; n = 282) and our own cohort of middle-age to older adults with and without ASD (n = 47) mostly available in ABIDE II (n = 35). We compared correlations between cortical measures and age in right-handed adults with ASD (n = 157) and similar NT adults (n = 172), controlling for IQ and site. Participants were 18–64 years of age (mean = 29.8 years; median = 26 years). Results: We found significant differences between diagnosis groups in the relationship between age and cortical thickness for areas of left frontal lobe (pars opercularis), temporal lobe (inferior gyrus, middle gyrus, banks of the superior temporal sulcus, and entorhinal cortex), parietal lobe (inferior gyrus), and lateral occipital lobe. For all areas, adults with ASD showed a greater negative correlation between age and cortical thickness than NT adults. Conclusion: As hypothesized, adults with ASD demonstrated exacerbated age-related cortical thinning, compared to NT adults. These differences were the largest and most extensive in the left temporal lobe. Future longitudinal work is warranted to investigate whether differences in brain age trajectories will translate to unique behavioral needs in older adults with ASD.

AB - Background: Over the course of the last 30 years, autism spectrum disorder (ASD) diagnoses have increased, thus identifying a large group of aging individuals with ASD. Currently, little is known regarding how aging will affect these individual's neuroanatomy, compared to the neurotypical (NT) population. Because of the anatomical overlap of ASD-related cortical pathology and age-related cortical thinning, both following an anterior-to-posterior severity gradient, we hypothesize adults with ASD will show larger age-related cortical thinning than NT adults. Methods: We analyzed cortical measurements using available data from the multi-site Autism Brain Imaging Data Exchange I (ABIDE I; n = 282) and our own cohort of middle-age to older adults with and without ASD (n = 47) mostly available in ABIDE II (n = 35). We compared correlations between cortical measures and age in right-handed adults with ASD (n = 157) and similar NT adults (n = 172), controlling for IQ and site. Participants were 18–64 years of age (mean = 29.8 years; median = 26 years). Results: We found significant differences between diagnosis groups in the relationship between age and cortical thickness for areas of left frontal lobe (pars opercularis), temporal lobe (inferior gyrus, middle gyrus, banks of the superior temporal sulcus, and entorhinal cortex), parietal lobe (inferior gyrus), and lateral occipital lobe. For all areas, adults with ASD showed a greater negative correlation between age and cortical thickness than NT adults. Conclusion: As hypothesized, adults with ASD demonstrated exacerbated age-related cortical thinning, compared to NT adults. These differences were the largest and most extensive in the left temporal lobe. Future longitudinal work is warranted to investigate whether differences in brain age trajectories will translate to unique behavioral needs in older adults with ASD.

KW - Aging

KW - ASD

KW - Autism

KW - Brain

KW - Cortical thickness

KW - Gray matter

KW - MRI

KW - Temporal lobe

UR - http://www.scopus.com/inward/record.url?scp=85064090332&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064090332&partnerID=8YFLogxK

U2 - 10.1016/j.rasd.2019.03.005

DO - 10.1016/j.rasd.2019.03.005

M3 - Article

VL - 64

SP - 31

EP - 38

JO - Research in Autism Spectrum Disorders

JF - Research in Autism Spectrum Disorders

SN - 1750-9467

ER -