Thermal considerations in murine tumor killing using hematoporphyrin derivative phototherapy

J. H. Kinsey, Denis Cortese, H. B. Neel

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Tumor cell killing utilizing hematoporphyrin derivative (HPD) phototherapy was studied in a murine tumor model to assess the relative importance of intratumor temperature in causing the tumoricidal effect. Temperature measurements and tumor killing without HPD strongly suggest that HPD phototherapy as reported previously by other workers has at least partially a hyperthermic effect. Also, it is shown that, in this tumor model, tissue light attenuation restricts the radius of action of the light-HPD interaction to approximately 4 mm.

Original languageEnglish (US)
Pages (from-to)1562-1567
Number of pages6
JournalCancer Research
Volume43
Issue number4
StatePublished - 1983
Externally publishedYes

Fingerprint

Hematoporphyrin Derivative
Phototherapy
Hot Temperature
Neoplasms
Light
Temperature

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Thermal considerations in murine tumor killing using hematoporphyrin derivative phototherapy. / Kinsey, J. H.; Cortese, Denis; Neel, H. B.

In: Cancer Research, Vol. 43, No. 4, 1983, p. 1562-1567.

Research output: Contribution to journalArticle

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