Thermal Considerations in Murine Tumor Killing Using Hematoporphyrin Derivative Phototherapy

J. H. Kinsey; D. A. Cortese; H. B. Neel

Thermal Considerations in Murine Tumor Killing Using Hematoporphyrin Derivative Phototherapy

J. H. Kinsey, D. A. Cortese, H. B. Neel

Research output: Contribution to journal › Article › peer-review

Abstract

Tumor cell killing utilizing hematoporphyrin derivative (HPD) phototherapy was studied in a murine tumor model to assess the relative importance of intratumor temperature in causing the tumoricidal effect. Temperature measurements and tumor killing without HPD strongly suggest that HPD phototherapy as reported previously by other workers has at least partially a hyperthermic effect. Also, it is shown that, in this tumor model, tissue light attenuation restricts the radius of action of the light-HPD interaction to approximately 4 mm.

Original language	English (US)
Pages (from-to)	1562-1567
Number of pages	6
Journal	Cancer Research
Volume	43
Issue number	4
State	Published - Apr 1 1983
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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abstract = "Tumor cell killing utilizing hematoporphyrin derivative (HPD) phototherapy was studied in a murine tumor model to assess the relative importance of intratumor temperature in causing the tumoricidal effect. Temperature measurements and tumor killing without HPD strongly suggest that HPD phototherapy as reported previously by other workers has at least partially a hyperthermic effect. Also, it is shown that, in this tumor model, tissue light attenuation restricts the radius of action of the light-HPD interaction to approximately 4 mm.",

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AB - Tumor cell killing utilizing hematoporphyrin derivative (HPD) phototherapy was studied in a murine tumor model to assess the relative importance of intratumor temperature in causing the tumoricidal effect. Temperature measurements and tumor killing without HPD strongly suggest that HPD phototherapy as reported previously by other workers has at least partially a hyperthermic effect. Also, it is shown that, in this tumor model, tissue light attenuation restricts the radius of action of the light-HPD interaction to approximately 4 mm.

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Thermal Considerations in Murine Tumor Killing Using Hematoporphyrin Derivative Phototherapy

Abstract

ASJC Scopus subject areas

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