The yeast α-factor receptor: Structural properties deduced from the sequence of the STE2 gene

Anne C. Burkholder, Leland Hartwell

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

The STE2 gene of the yeast Saccharomyces cerevisiae encodes a component of the receptor for the oligopeptide pheromone α-factor (1). We have cloned and determined the nucleotide sequence of the STE2 gene. A sequence involved in the control of cell-type expression of the STE2 gene (2,3) was found 5′ of an open reading frame that could encode a protein of 431 amino acids. The predicted STE2 protein contains seven hydrophobic segments, suggesting that the α-factor receptor is an integral membrane protein. No extensive homology at the primary sequence level was detected between the predicted STE2 protein and other available protein sequences.

Original languageEnglish (US)
Pages (from-to)8463-8475
Number of pages13
JournalNucleic Acids Research
Volume13
Issue number23
DOIs
StatePublished - Dec 9 1985
Externally publishedYes

Fingerprint

Yeast
Structural Properties
Receptor
Structural properties
Genes
Yeasts
Gene
Proteins
Protein
Membrane Protein
Pheromone Receptors
Pheromone
Saccharomyces Cerevisiae
Protein Sequence
Oligopeptides
Amino Acids
Homology
Pheromones
Open Reading Frames
Saccharomyces cerevisiae

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)
  • Genetics

Cite this

The yeast α-factor receptor : Structural properties deduced from the sequence of the STE2 gene. / Burkholder, Anne C.; Hartwell, Leland.

In: Nucleic Acids Research, Vol. 13, No. 23, 09.12.1985, p. 8463-8475.

Research output: Contribution to journalArticle

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