The yeast α-factor receptor: Structural properties deduced from the sequence of the STE2 gene

Anne C. Burkholder, Leland H. Hartwell

Research output: Contribution to journalArticlepeer-review

177 Scopus citations

Abstract

The STE2 gene of the yeast Saccharomyces cerevisiae encodes a component of the receptor for the oligopeptide pheromone α-factor (1). We have cloned and determined the nucleotide sequence of the STE2 gene. A sequence involved in the control of cell-type expression of the STE2 gene (2,3) was found 5′ of an open reading frame that could encode a protein of 431 amino acids. The predicted STE2 protein contains seven hydrophobic segments, suggesting that the α-factor receptor is an integral membrane protein. No extensive homology at the primary sequence level was detected between the predicted STE2 protein and other available protein sequences.

Original languageEnglish (US)
Pages (from-to)8463-8475
Number of pages13
JournalNucleic acids research
Volume13
Issue number23
DOIs
StatePublished - Dec 9 1985
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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