The validity, stability, and utility of measuring uric acid in saliva

Jenna L. Riis; Crystal I. Bryce; Marla J. Matin; John L. Stebbins; Olga Kornienko; Lauren Van Huisstede; Douglas A. Granger

doi:10.2217/bmm-2017-0336

The validity, stability, and utility of measuring uric acid in saliva

Jenna L. Riis, Crystal I. Bryce, Marla J. Matin, John L. Stebbins, Olga Kornienko, Lauren Van Huisstede, Douglas A. Granger

Social and Family Dynamics, T. Denny Sanford School of (SSFD)

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Aim: Serum uric acid (UA) is associated with many health conditions, including kidney, cardiovascular, and metabolic disorders. We examined the validity and stability of salivary UA as a noninvasive measure of serum UA. Materials & methods: Using serum and salivary UA data from healthy adults (n = 99), we examined the UA serum-saliva correlation, and UA associations with adiponectin and C-reactive protein. Using longitudinal data from young adults (n = 182), we examined salivary UA stability. Results: We found robust positive serum-saliva correlations for UA. UA and adiponectin were inversely related in serum and saliva. Salivary UA was relatively stable; 62-66% of variance could be attributed to a latent trait-like component. Conclusion: Salivary UA may be an important biomarker indexing health and disease risk.

Original language	English (US)
Pages (from-to)	583-596
Number of pages	14
Journal	Biomarkers in Medicine
Volume	12
Issue number	6
DOIs	https://doi.org/10.2217/bmm-2017-0336
State	Published - Jun 2018

Keywords

C-reactive protein
adiponectin
biomarker
body mass index
latent state-trait modeling
saliva
serum
uric acid

ASJC Scopus subject areas

Drug Discovery
Clinical Biochemistry
Biochemistry, medical

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title = "The validity, stability, and utility of measuring uric acid in saliva",

abstract = "Aim: Serum uric acid (UA) is associated with many health conditions, including kidney, cardiovascular, and metabolic disorders. We examined the validity and stability of salivary UA as a noninvasive measure of serum UA. Materials & methods: Using serum and salivary UA data from healthy adults (n = 99), we examined the UA serum-saliva correlation, and UA associations with adiponectin and C-reactive protein. Using longitudinal data from young adults (n = 182), we examined salivary UA stability. Results: We found robust positive serum-saliva correlations for UA. UA and adiponectin were inversely related in serum and saliva. Salivary UA was relatively stable; 62-66% of variance could be attributed to a latent trait-like component. Conclusion: Salivary UA may be an important biomarker indexing health and disease risk.",

keywords = "C-reactive protein, adiponectin, biomarker, body mass index, latent state-trait modeling, saliva, serum, uric acid",

author = "Riis, {Jenna L.} and Bryce, {Crystal I.} and Matin, {Marla J.} and Stebbins, {John L.} and Olga Kornienko and {Van Huisstede}, Lauren and Granger, {Douglas A.}",

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year = "2018",

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doi = "10.2217/bmm-2017-0336",

language = "English (US)",

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AU - Riis, Jenna L.

AU - Bryce, Crystal I.

AU - Matin, Marla J.

AU - Stebbins, John L.

AU - Kornienko, Olga

AU - Van Huisstede, Lauren

AU - Granger, Douglas A.

PY - 2018/6

Y1 - 2018/6

N2 - Aim: Serum uric acid (UA) is associated with many health conditions, including kidney, cardiovascular, and metabolic disorders. We examined the validity and stability of salivary UA as a noninvasive measure of serum UA. Materials & methods: Using serum and salivary UA data from healthy adults (n = 99), we examined the UA serum-saliva correlation, and UA associations with adiponectin and C-reactive protein. Using longitudinal data from young adults (n = 182), we examined salivary UA stability. Results: We found robust positive serum-saliva correlations for UA. UA and adiponectin were inversely related in serum and saliva. Salivary UA was relatively stable; 62-66% of variance could be attributed to a latent trait-like component. Conclusion: Salivary UA may be an important biomarker indexing health and disease risk.

AB - Aim: Serum uric acid (UA) is associated with many health conditions, including kidney, cardiovascular, and metabolic disorders. We examined the validity and stability of salivary UA as a noninvasive measure of serum UA. Materials & methods: Using serum and salivary UA data from healthy adults (n = 99), we examined the UA serum-saliva correlation, and UA associations with adiponectin and C-reactive protein. Using longitudinal data from young adults (n = 182), we examined salivary UA stability. Results: We found robust positive serum-saliva correlations for UA. UA and adiponectin were inversely related in serum and saliva. Salivary UA was relatively stable; 62-66% of variance could be attributed to a latent trait-like component. Conclusion: Salivary UA may be an important biomarker indexing health and disease risk.

KW - C-reactive protein

KW - adiponectin

KW - biomarker

KW - body mass index

KW - latent state-trait modeling

KW - saliva

KW - serum

KW - uric acid

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The validity, stability, and utility of measuring uric acid in saliva

Abstract

Keywords

ASJC Scopus subject areas

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