The Rhesus Macaque as a Translational Model for Neurodegeneration and Alzheimer’s Disease

Gail A. Stonebarger, Heather A. Bimonte-Nelson, Henryk F. Urbanski

Research output: Contribution to journalReview articlepeer-review

Abstract

A major obstacle to progress in understanding the etiology of normative and pathological human brain aging is the availability of suitable animal models for experimentation. The present article will highlight our current knowledge regarding human brain aging and neurodegeneration, specifically in the context of Alzheimer’s disease (AD). Additionally, it will examine the use of the rhesus macaque monkey as a pragmatic translational animal model in which to study underlying causal mechanisms. Specifically, the discussion will focus on behavioral and protein-level brain changes that occur within the central nervous system (CNS) of aged monkeys, and compare them to the changes observed in humans during clinically normative aging and in AD.

Original languageEnglish (US)
Article number734173
JournalFrontiers in Aging Neuroscience
Volume13
DOIs
StatePublished - Sep 3 2021

Keywords

  • amyloid beta
  • animal models
  • brain aging
  • clinical aging
  • cognitive decline
  • non-human primate
  • phosphorylated tau

ASJC Scopus subject areas

  • Aging
  • Cognitive Neuroscience

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