The relation of sugar intake to β cell function in overweight Latino children

Jaimie N. Davis, Emily E. Ventura, Marc J. Weigensberg, Geoff D C Ball, Martha L. Cruz, Gabriel Shaibi, Michael I. Goran

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Background: Few studies have investigated the association between sugar intake and insulin dynamics in children, and none have examined this association in overweight Latino youth. Objective: We aimed to examine the relation between dietary components, especially sugar intake, and insulin dynamics in overweight Latino youth. Design: We examined 63 overweight Latino children aged 9-13 y. Dietary intake was determined by 3-d records, and body composition was measured with dual-energy X-ray absorptiometry. Insulin sensitivity (SI), acute insulin response (AIR), and disposition index (an index of β cell function) were measured by using a frequently sampled intravenous-glucose- tolerance test and minimal modeling. Hierarchical regression analysis ascertained the potential independent relation between insulin dynamics and dietary components. Results: The relation between macronutrient intake and any variable related to insulin dynamics was not significant. However, higher total sugar intake, although not related to SI, was significantly associated with lower AIR (β = -0.296, P = 0.045) and lower β cell function (β = -0.421, P = 0.043), independent of the covariates age, sex, body composition, Tanner stage, and energy intake. Sugar-sweetened beverage intakes trended toward inverse association with lower AIR (β = -0.219, P = 0.072) and β cell function (β = -0.298, P = 0.077). Conclusions: In overweight Latino children, higher intakes of sugar and sugar-sweetened beverages were associated with lower AIR and disposition index, which suggested that these children already have early signs of poor β cell function. These results emphasize the need for early nutritional interventions to reduce daily sugar intake in overweight Latino children and potentially reduce their risk for type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)1004-1010
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume82
Issue number5
StatePublished - 2005
Externally publishedYes

Fingerprint

Hispanic Americans
insulin
Insulin
sugars
cells
Beverages
Body Composition
beverages
body composition
dual-energy X-ray absorptiometry
nutritional intervention
Photon Absorptiometry
Glucose Tolerance Test
Energy Intake
noninsulin-dependent diabetes mellitus
insulin resistance
Type 2 Diabetes Mellitus
Insulin Resistance
food intake
energy intake

Keywords

  • β cells
  • Disposition index
  • Latino adolescents
  • Obesity
  • Overweight
  • Sugar
  • Sugary beverages
  • Type 2 diabetes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Davis, J. N., Ventura, E. E., Weigensberg, M. J., Ball, G. D. C., Cruz, M. L., Shaibi, G., & Goran, M. I. (2005). The relation of sugar intake to β cell function in overweight Latino children. American Journal of Clinical Nutrition, 82(5), 1004-1010.

The relation of sugar intake to β cell function in overweight Latino children. / Davis, Jaimie N.; Ventura, Emily E.; Weigensberg, Marc J.; Ball, Geoff D C; Cruz, Martha L.; Shaibi, Gabriel; Goran, Michael I.

In: American Journal of Clinical Nutrition, Vol. 82, No. 5, 2005, p. 1004-1010.

Research output: Contribution to journalArticle

Davis, JN, Ventura, EE, Weigensberg, MJ, Ball, GDC, Cruz, ML, Shaibi, G & Goran, MI 2005, 'The relation of sugar intake to β cell function in overweight Latino children', American Journal of Clinical Nutrition, vol. 82, no. 5, pp. 1004-1010.
Davis JN, Ventura EE, Weigensberg MJ, Ball GDC, Cruz ML, Shaibi G et al. The relation of sugar intake to β cell function in overweight Latino children. American Journal of Clinical Nutrition. 2005;82(5):1004-1010.
Davis, Jaimie N. ; Ventura, Emily E. ; Weigensberg, Marc J. ; Ball, Geoff D C ; Cruz, Martha L. ; Shaibi, Gabriel ; Goran, Michael I. / The relation of sugar intake to β cell function in overweight Latino children. In: American Journal of Clinical Nutrition. 2005 ; Vol. 82, No. 5. pp. 1004-1010.
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