The phylogeny of enkephalins: Speculations on the origins of opioid precursors

Robert M. Dores; Lorraine K. McDonald; Alex Goldsmith; Pierre Deviche; David A. Rubin

doi:10.1159/000154686

The phylogeny of enkephalins: Speculations on the origins of opioid precursors

Robert M. Dores, Lorraine K. McDonald, Alex Goldsmith, Pierre Deviche, David A. Rubin

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Enkephalins, dynorphins and β-endorphin are endogenous opiate-like substances that are differentially distributed among vertebrate taxa. Enkephalins have the widest distribution, and the proenkephalin gene would appear to represent the ancestral opioid gene. This review will consider the following hypothesis: the evolution of the opioids occurred as a result of two duplications of the proenkephalin gene. In this hypothesis, the first duplication event would have given rise to the proopiomelanocortin gene, the precursor for β-endorphin, and the second duplication event would have given rise to the prodynorphin gene.

Original language	English (US)
Pages (from-to)	231-244
Number of pages	14
Journal	Cellular Physiology and Biochemistry
Volume	3
Issue number	3-4
DOIs	https://doi.org/10.1159/000154686
State	Published - Jan 1 1993
Externally published	Yes

Keywords

Enkephalins
Prodynorphin
Proenkephalin
Proopiomelanocortin

ASJC Scopus subject areas

Physiology

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10.1159/000154686

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abstract = "Enkephalins, dynorphins and β-endorphin are endogenous opiate-like substances that are differentially distributed among vertebrate taxa. Enkephalins have the widest distribution, and the proenkephalin gene would appear to represent the ancestral opioid gene. This review will consider the following hypothesis: the evolution of the opioids occurred as a result of two duplications of the proenkephalin gene. In this hypothesis, the first duplication event would have given rise to the proopiomelanocortin gene, the precursor for β-endorphin, and the second duplication event would have given rise to the prodynorphin gene.",

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AU - Rubin, David A.

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AB - Enkephalins, dynorphins and β-endorphin are endogenous opiate-like substances that are differentially distributed among vertebrate taxa. Enkephalins have the widest distribution, and the proenkephalin gene would appear to represent the ancestral opioid gene. This review will consider the following hypothesis: the evolution of the opioids occurred as a result of two duplications of the proenkephalin gene. In this hypothesis, the first duplication event would have given rise to the proopiomelanocortin gene, the precursor for β-endorphin, and the second duplication event would have given rise to the prodynorphin gene.

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The phylogeny of enkephalins: Speculations on the origins of opioid precursors

Abstract

Keywords

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