The origin of Metazoa: A transition from temporal to spatial cell differentiation

Kirill V. Mikhailov, Anastasiya V. Konstantinova, Mikhail A. Nikitin, Peter V. Troshin, Leonid Yu Rusin, Vassily A. Lyubetsky, Yuri V. Panchin, Alexander P. Mylnikov, Leonid L. Moroz, Sudhir Kumar, Vladimir V. Aleoshin

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52 Scopus citations

Abstract

For over a century, Haeckel's Gastraea theory remained a dominant theory to explain the origin of multicellular animals. According to this theory, the animal ancestor was a blastula-like colony of uniform cells that gradually evolved cell differentiation. Today, however, genes that typically control metazoan development, cell differentiation, cell-to-cell adhesion, and cell-to-matrix adhesion are found in various unicellular relatives of the Metazoa, which suggests the origin of the genetic programs of cell differentiation and adhesion in the root of the Opisthokonta. Multicellular stages occurring in the complex life cycles of opisthokont protists (mesomycetozoeans and choanoflagellates) never resemble a blastula. Here, we discuss a more realistic scenario of transition to multi-cellularity through integration of pre-existing transient cell types into the body of an early metazoon, which possessed a complex life cycle with a differentiated sedentary filter-feeding trophic stage and a non-feeding blastula-like larva, the synzoospore. Choanoflagellates are considered as forms with secondarily simplified life cycles.

Original languageEnglish (US)
Pages (from-to)758-768
Number of pages11
JournalBioEssays
Volume31
Issue number7
DOIs
StatePublished - Oct 15 2009

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Keywords

  • Ichthyosporea
  • Molecular phylogenetics
  • Origin of Metazoa
  • Rel/NF kappa B
  • T-box family

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Mikhailov, K. V., Konstantinova, A. V., Nikitin, M. A., Troshin, P. V., Rusin, L. Y., Lyubetsky, V. A., Panchin, Y. V., Mylnikov, A. P., Moroz, L. L., Kumar, S., & Aleoshin, V. V. (2009). The origin of Metazoa: A transition from temporal to spatial cell differentiation. BioEssays, 31(7), 758-768. https://doi.org/10.1002/bies.200800214