The origin of Metazoa: A transition from temporal to spatial cell differentiation

Kirill V. Mikhailov, Anastasiya V. Konstantinova, Mikhail A. Nikitin, Peter V. Troshin, Leonid Yu Rusin, Vassily A. Lyubetsky, Yuri V. Panchin, Alexander P. Mylnikov, Leonid L. Moroz, Sudhir Kumar, Vladimir V. Aleoshin

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

For over a century, Haeckel's Gastraea theory remained a dominant theory to explain the origin of multicellular animals. According to this theory, the animal ancestor was a blastula-like colony of uniform cells that gradually evolved cell differentiation. Today, however, genes that typically control metazoan development, cell differentiation, cell-to-cell adhesion, and cell-to-matrix adhesion are found in various unicellular relatives of the Metazoa, which suggests the origin of the genetic programs of cell differentiation and adhesion in the root of the Opisthokonta. Multicellular stages occurring in the complex life cycles of opisthokont protists (mesomycetozoeans and choanoflagellates) never resemble a blastula. Here, we discuss a more realistic scenario of transition to multi-cellularity through integration of pre-existing transient cell types into the body of an early metazoon, which possessed a complex life cycle with a differentiated sedentary filter-feeding trophic stage and a non-feeding blastula-like larva, the synzoospore. Choanoflagellates are considered as forms with secondarily simplified life cycles.

Original languageEnglish (US)
Pages (from-to)758-768
Number of pages11
JournalBioEssays
Volume31
Issue number7
DOIs
StatePublished - 2009

Fingerprint

Blastula
Life cycle
Cell Differentiation
Choanoflagellata
Life Cycle Stages
Animals
Adhesion
Cell Adhesion
Cell adhesion
Cell-Matrix Junctions
Genes
Larva

Keywords

  • Ichthyosporea
  • Molecular phylogenetics
  • Origin of Metazoa
  • Rel/NF kappa B
  • T-box family

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Mikhailov, K. V., Konstantinova, A. V., Nikitin, M. A., Troshin, P. V., Rusin, L. Y., Lyubetsky, V. A., ... Aleoshin, V. V. (2009). The origin of Metazoa: A transition from temporal to spatial cell differentiation. BioEssays, 31(7), 758-768. https://doi.org/10.1002/bies.200800214

The origin of Metazoa : A transition from temporal to spatial cell differentiation. / Mikhailov, Kirill V.; Konstantinova, Anastasiya V.; Nikitin, Mikhail A.; Troshin, Peter V.; Rusin, Leonid Yu; Lyubetsky, Vassily A.; Panchin, Yuri V.; Mylnikov, Alexander P.; Moroz, Leonid L.; Kumar, Sudhir; Aleoshin, Vladimir V.

In: BioEssays, Vol. 31, No. 7, 2009, p. 758-768.

Research output: Contribution to journalArticle

Mikhailov, KV, Konstantinova, AV, Nikitin, MA, Troshin, PV, Rusin, LY, Lyubetsky, VA, Panchin, YV, Mylnikov, AP, Moroz, LL, Kumar, S & Aleoshin, VV 2009, 'The origin of Metazoa: A transition from temporal to spatial cell differentiation', BioEssays, vol. 31, no. 7, pp. 758-768. https://doi.org/10.1002/bies.200800214
Mikhailov KV, Konstantinova AV, Nikitin MA, Troshin PV, Rusin LY, Lyubetsky VA et al. The origin of Metazoa: A transition from temporal to spatial cell differentiation. BioEssays. 2009;31(7):758-768. https://doi.org/10.1002/bies.200800214
Mikhailov, Kirill V. ; Konstantinova, Anastasiya V. ; Nikitin, Mikhail A. ; Troshin, Peter V. ; Rusin, Leonid Yu ; Lyubetsky, Vassily A. ; Panchin, Yuri V. ; Mylnikov, Alexander P. ; Moroz, Leonid L. ; Kumar, Sudhir ; Aleoshin, Vladimir V. / The origin of Metazoa : A transition from temporal to spatial cell differentiation. In: BioEssays. 2009 ; Vol. 31, No. 7. pp. 758-768.
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