The origin and evolution of cell types

Detlev Arendt, Jacob M. Musser, Clare V H Baker, Aviv Bergman, Connie Cepko, Douglas H. Erwin, Mihaela Pavlicev, Gerhard Schlosser, Stefanie Widder, Manfred Laubichler, Günter P. Wagner

Research output: Contribution to journalReview article

96 Citations (Scopus)

Abstract

Cell types are the basic building blocks of multicellular organisms and are extensively diversified in animals. Despite recent advances in characterizing cell types, classification schemes remain ambiguous. We propose an evolutionary definition of a cell type that allows cell types to be delineated and compared within and between species. Key to cell type identity are evolutionary changes in the 'core regulatory complex' (CoRC) of transcription factors, that make emergent sister cell types distinct, enable their independent evolution and regulate cell type-specific traits termed apomeres. We discuss the distinction between developmental and evolutionary lineages, and present a roadmap for future research.

Original languageEnglish (US)
Pages (from-to)744-757
Number of pages14
JournalNature Reviews Genetics
Volume17
Issue number12
DOIs
StatePublished - Dec 1 2016

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Arendt, D., Musser, J. M., Baker, C. V. H., Bergman, A., Cepko, C., Erwin, D. H., ... Wagner, G. P. (2016). The origin and evolution of cell types. Nature Reviews Genetics, 17(12), 744-757. https://doi.org/10.1038/nrg.2016.127

The origin and evolution of cell types. / Arendt, Detlev; Musser, Jacob M.; Baker, Clare V H; Bergman, Aviv; Cepko, Connie; Erwin, Douglas H.; Pavlicev, Mihaela; Schlosser, Gerhard; Widder, Stefanie; Laubichler, Manfred; Wagner, Günter P.

In: Nature Reviews Genetics, Vol. 17, No. 12, 01.12.2016, p. 744-757.

Research output: Contribution to journalReview article

Arendt, D, Musser, JM, Baker, CVH, Bergman, A, Cepko, C, Erwin, DH, Pavlicev, M, Schlosser, G, Widder, S, Laubichler, M & Wagner, GP 2016, 'The origin and evolution of cell types', Nature Reviews Genetics, vol. 17, no. 12, pp. 744-757. https://doi.org/10.1038/nrg.2016.127
Arendt D, Musser JM, Baker CVH, Bergman A, Cepko C, Erwin DH et al. The origin and evolution of cell types. Nature Reviews Genetics. 2016 Dec 1;17(12):744-757. https://doi.org/10.1038/nrg.2016.127
Arendt, Detlev ; Musser, Jacob M. ; Baker, Clare V H ; Bergman, Aviv ; Cepko, Connie ; Erwin, Douglas H. ; Pavlicev, Mihaela ; Schlosser, Gerhard ; Widder, Stefanie ; Laubichler, Manfred ; Wagner, Günter P. / The origin and evolution of cell types. In: Nature Reviews Genetics. 2016 ; Vol. 17, No. 12. pp. 744-757.
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