The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse

Andrew J. McGeehan, M. Foster Olive

Research output: Contribution to journalArticle

151 Scopus citations

Abstract

We examined the ability of 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a selective antagonist of the type 5 metabotropic glutamate receptor (mGluR5), to reduce the rewarding effects of various drugs of abuse in the conditioned place preference (CPP) paradigm. Mice were treated with MPEP (1, 5, and 20 mg/kg i.p.) 10 min prior to cocaine (15 mg/kg i.p.), D-amphetamine (2 mg/kg i.p.), nicotine (0.5 mg/kg i.p.), morphine (5 mg/kg i.p.), or ethanol (2 g/kg i.p.) on 3 successive days of CPP conditioning trials. MPEP pretreatment dose-dependently reduced the development of CPP for cocaine only. When tested alone at the doses effective in reducing CPP, MPEP produced neither a place preference nor aversion. These data provide further support for a role of the mGluR5 receptor in the rewarding effects of cocaine.

Original languageEnglish (US)
Pages (from-to)240-242
Number of pages3
JournalSynapse
Volume47
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

Keywords

  • Amphetamine
  • Cocaine
  • Conditioned place preference
  • Ethanol
  • Glutamate
  • Morphine
  • Nicotine
  • Reward
  • mGluR5

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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