The gene csd is the primary signal for sexual development in the honeybee and encodes an SR-type protein

Martin Beye, Martin Hasselmann, M. Kim Fondrk, Robert Page, Stig W. Omholt

Research output: Contribution to journalArticle

315 Citations (Scopus)

Abstract

Haplodiploid organisms comprise about 20% of animals. Males develop from unfertilized eggs while females are derived from fertilized eggs. The underlying mechanisms of sex determination, however, appear to be diverse and are poorly understood. We have dissected the complementary sex determiner (csd) locus in the honeybee to understand its molecular basis. In this species, csd acts as the primary sex-determining signal with several alleles segregating in populations. Males are hemizygous and females are heterozygous at this locus; nonreproducing diploid males occur when the locus is homozygous. We have characterized csd by positional cloning and repression analysis. csd alleles are highly variable and no transcription differences were found between sexes. These results establish csd as a primary signal that governs sexual development by its allelic composition. Structural similarity of csd with tra genes of Dipteran insects suggests some functional relation of what would otherwise appear to be unrelated sex-determination mechanisms.

Original languageEnglish (US)
Pages (from-to)419-429
Number of pages11
JournalCell
Volume114
Issue number4
DOIs
StatePublished - Aug 22 2003
Externally publishedYes

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Sexual Development
Cloning
Transcription
Animals
Genes
Chemical analysis
Proteins
Insect Genes
Alleles
Zygote
Diploidy
Ovum
Organism Cloning

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

The gene csd is the primary signal for sexual development in the honeybee and encodes an SR-type protein. / Beye, Martin; Hasselmann, Martin; Fondrk, M. Kim; Page, Robert; Omholt, Stig W.

In: Cell, Vol. 114, No. 4, 22.08.2003, p. 419-429.

Research output: Contribution to journalArticle

Beye, Martin ; Hasselmann, Martin ; Fondrk, M. Kim ; Page, Robert ; Omholt, Stig W. / The gene csd is the primary signal for sexual development in the honeybee and encodes an SR-type protein. In: Cell. 2003 ; Vol. 114, No. 4. pp. 419-429.
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