The evolvability of lead peptides from small library screens

Jinglei Zhang; Berea A R Williams; Mikael T. Nilsson; John C. Chaput

doi:10.1039/c0cc01475c

The evolvability of lead peptides from small library screens

Jinglei Zhang, Berea A R Williams, Mikael T. Nilsson, John C. Chaput

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Very little is known about the evolvability of lead peptides that are isolated from small library screens. Here we begin to explore this question by comparing the directed evolution of two peptides previously isolated from a small library screen to new ligands generated de novo by in vitro selection.

Original language	English (US)
Pages (from-to)	7778-7780
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	41
DOIs	https://doi.org/10.1039/c0cc01475c
State	Published - Nov 7 2010

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "The evolvability of lead peptides from small library screens",

abstract = "Very little is known about the evolvability of lead peptides that are isolated from small library screens. Here we begin to explore this question by comparing the directed evolution of two peptides previously isolated from a small library screen to new ligands generated de novo by in vitro selection.",

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The evolvability of lead peptides from small library screens

Abstract

ASJC Scopus subject areas

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