The evolution of genetic networks by non-adaptive processes

Research output: Contribution to journalArticle

202 Citations (Scopus)

Abstract

Although numerous investigators assume that the global features of genetic networks are moulded by natural selection, there has been no formal demonstration of the adaptive origin of any genetic network. This Analysis shows that many of the qualitative features of known transcriptional networks can arise readily through the non-adaptive processes of genetic drift, mutation and recombination, raising questions about whether natural selection is necessary or even sufficient for the origin of many aspects of gene-network topologies. The widespread reliance on computational procedures that are devoid of population-genetic details to generate hypotheses for the evolution of network configurations seems to be unjustified.

Original languageEnglish (US)
Pages (from-to)803-813
Number of pages11
JournalNature Reviews Genetics
Volume8
Issue number10
DOIs
StatePublished - Oct 1 2007
Externally publishedYes

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Molecular Evolution
Gene Regulatory Networks
Genetic Selection
Genetic Drift
Population Genetics
Genetic Recombination
Research Personnel
Mutation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

The evolution of genetic networks by non-adaptive processes. / Lynch, Michael.

In: Nature Reviews Genetics, Vol. 8, No. 10, 01.10.2007, p. 803-813.

Research output: Contribution to journalArticle

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