The dynamics of mutations associated with anti-malarial drug resistance in Plasmodium falciparum

Ananias A. Escalante, David L. Smith, Yuseob Kim

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The evolution of resistance in Plasmodium falciparum against safe and affordable drugs such as chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) is a major global health threat. Investigating the dynamics of resistance against these antimalarial drugs will lead to approaches for addressing the problem of resistance in malarial parasites that are solidly based in evolutionary genetics and population biology. In this article, we discuss current developments in population biology modeling and evolutionary genetics. Despite great advancements achieved in the past decade, understanding the complex dynamics of mutations conferring drug resistance in P. falciparum requires approaches that consider the parasite population structure among other demographic processes.

Original languageEnglish (US)
Pages (from-to)557-563
Number of pages7
JournalTrends in Parasitology
Volume25
Issue number12
DOIs
StatePublished - Dec 2009

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Antimalarials
Plasmodium falciparum
Drug Resistance
Parasites
Mutation
Chloroquine
Population Genetics
Population
Demography
Pharmaceutical Preparations
Global Health
pyrimethamine drug combination fanasil

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Cite this

The dynamics of mutations associated with anti-malarial drug resistance in Plasmodium falciparum. / Escalante, Ananias A.; Smith, David L.; Kim, Yuseob.

In: Trends in Parasitology, Vol. 25, No. 12, 12.2009, p. 557-563.

Research output: Contribution to journalArticle

Escalante, Ananias A. ; Smith, David L. ; Kim, Yuseob. / The dynamics of mutations associated with anti-malarial drug resistance in Plasmodium falciparum. In: Trends in Parasitology. 2009 ; Vol. 25, No. 12. pp. 557-563.
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