The chemistry of toxic principles from Maytenus nemerosa

Fang Sheng-Ding, David E. Berry, David G. Lynn, Sidney M. Hecht, James Campbell, William S. Lynn

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Maytenus nemerosa has been fractionated systematically by following the toxicity of extracts, partitioned solutions and column chromatographic fractions against cultured KB cells. Several compounds were isolated in this fashion, including 3-oxo-20(29)-lupen-30-al, β-amyrin, 29-hydroxyfriedelan-3-one, 30-hydroxy-20(29)-lupen-3-one, 30-hydroxyfriedelan-3-one and lup-20(29)-ene-3β,30-diol, as well as tingenone, 20-hydroxytingenone and galactitol. 3-Oxo-20(29)-lupen-30-al was shown to be cytotoxic for the first time; the structural basis of this cytotoxicity was investigated, in part, by bioassay of four products obtained by chemical transformation of single, isolated principles.

Original languageEnglish (US)
Pages (from-to)631-633
Number of pages3
JournalPhytochemistry
Volume23
Issue number3
DOIs
StatePublished - 1984
Externally publishedYes

Keywords

  • Celastraceae
  • Maytenus nemerosa
  • antineoplastic agents
  • cytotoxic principles
  • pentacyclic triterpenes.

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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  • Cite this

    Sheng-Ding, F., Berry, D. E., Lynn, D. G., Hecht, S. M., Campbell, J., & Lynn, W. S. (1984). The chemistry of toxic principles from Maytenus nemerosa. Phytochemistry, 23(3), 631-633. https://doi.org/10.1016/S0031-9422(00)80396-9