The chemistry of toxic principles from Maytenus nemerosa

Fang Sheng-Ding; David E. Berry; David G. Lynn; Sidney M. Hecht; James Campbell; William S. Lynn

doi:10.1016/S0031-9422(00)80396-9

The chemistry of toxic principles from Maytenus nemerosa

Fang Sheng-Ding, David E. Berry, David G. Lynn, Sidney M. Hecht, James Campbell, William S. Lynn

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Maytenus nemerosa has been fractionated systematically by following the toxicity of extracts, partitioned solutions and column chromatographic fractions against cultured KB cells. Several compounds were isolated in this fashion, including 3-oxo-20(29)-lupen-30-al, β-amyrin, 29-hydroxyfriedelan-3-one, 30-hydroxy-20(29)-lupen-3-one, 30-hydroxyfriedelan-3-one and lup-20(29)-ene-3β,30-diol, as well as tingenone, 20-hydroxytingenone and galactitol. 3-Oxo-20(29)-lupen-30-al was shown to be cytotoxic for the first time; the structural basis of this cytotoxicity was investigated, in part, by bioassay of four products obtained by chemical transformation of single, isolated principles.

Original language	English (US)
Pages (from-to)	631-633
Number of pages	3
Journal	Phytochemistry
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/S0031-9422(00)80396-9
State	Published - 1984
Externally published	Yes

Keywords

Celastraceae
Maytenus nemerosa
antineoplastic agents
cytotoxic principles
pentacyclic triterpenes.

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

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10.1016/S0031-9422(00)80396-9

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title = "The chemistry of toxic principles from Maytenus nemerosa",

abstract = "Maytenus nemerosa has been fractionated systematically by following the toxicity of extracts, partitioned solutions and column chromatographic fractions against cultured KB cells. Several compounds were isolated in this fashion, including 3-oxo-20(29)-lupen-30-al, β-amyrin, 29-hydroxyfriedelan-3-one, 30-hydroxy-20(29)-lupen-3-one, 30-hydroxyfriedelan-3-one and lup-20(29)-ene-3β,30-diol, as well as tingenone, 20-hydroxytingenone and galactitol. 3-Oxo-20(29)-lupen-30-al was shown to be cytotoxic for the first time; the structural basis of this cytotoxicity was investigated, in part, by bioassay of four products obtained by chemical transformation of single, isolated principles.",

keywords = "Celastraceae, Maytenus nemerosa, antineoplastic agents, cytotoxic principles, pentacyclic triterpenes.",

author = "Fang Sheng-Ding and Berry, {David E.} and Lynn, {David G.} and Hecht, {Sidney M.} and James Campbell and Lynn, {William S.}",

year = "1984",

doi = "10.1016/S0031-9422(00)80396-9",

language = "English (US)",

volume = "23",

pages = "631--633",

journal = "Phytochemistry",

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publisher = "Elsevier Limited",

number = "3",

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T1 - The chemistry of toxic principles from Maytenus nemerosa

AU - Sheng-Ding, Fang

AU - Berry, David E.

AU - Lynn, David G.

AU - Hecht, Sidney M.

AU - Campbell, James

AU - Lynn, William S.

PY - 1984

Y1 - 1984

N2 - Maytenus nemerosa has been fractionated systematically by following the toxicity of extracts, partitioned solutions and column chromatographic fractions against cultured KB cells. Several compounds were isolated in this fashion, including 3-oxo-20(29)-lupen-30-al, β-amyrin, 29-hydroxyfriedelan-3-one, 30-hydroxy-20(29)-lupen-3-one, 30-hydroxyfriedelan-3-one and lup-20(29)-ene-3β,30-diol, as well as tingenone, 20-hydroxytingenone and galactitol. 3-Oxo-20(29)-lupen-30-al was shown to be cytotoxic for the first time; the structural basis of this cytotoxicity was investigated, in part, by bioassay of four products obtained by chemical transformation of single, isolated principles.

AB - Maytenus nemerosa has been fractionated systematically by following the toxicity of extracts, partitioned solutions and column chromatographic fractions against cultured KB cells. Several compounds were isolated in this fashion, including 3-oxo-20(29)-lupen-30-al, β-amyrin, 29-hydroxyfriedelan-3-one, 30-hydroxy-20(29)-lupen-3-one, 30-hydroxyfriedelan-3-one and lup-20(29)-ene-3β,30-diol, as well as tingenone, 20-hydroxytingenone and galactitol. 3-Oxo-20(29)-lupen-30-al was shown to be cytotoxic for the first time; the structural basis of this cytotoxicity was investigated, in part, by bioassay of four products obtained by chemical transformation of single, isolated principles.

KW - Celastraceae

KW - Maytenus nemerosa

KW - antineoplastic agents

KW - cytotoxic principles

KW - pentacyclic triterpenes.

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DO - 10.1016/S0031-9422(00)80396-9

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JO - Phytochemistry

JF - Phytochemistry

IS - 3

ER -

The chemistry of toxic principles from Maytenus nemerosa

Abstract

Keywords

ASJC Scopus subject areas

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