Americans spend a considerable amount of their waking-hours in sedentary behavior. Among the different places where sedentary behavior occurs, the workplace is one of the primary settings for prolonged sitting which is associated with poor health outcomes. This study aimed at understanding the needs and wants of office workers in relation to the products that help sedentary employees reduce their sitting time. The research was conducted using a holistic design approach, including IRB application, online survey, and data analysis methods. The primary goal of this study was to understand the barriers and motivators to sit less in the office, and explore the employees’ attitudes and experiences of using products to reduce their sitting time. Based on the findings, the design guidelines of product design in the workplace were proposed to improve their sedentary behaviors that cause public health-related outcomes.