The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion

Marco Padilla-Rodriguez, Sara S. Parker, Deanna G. Adams, Thomas Westerling, Julieann I. Puleo, Adam W. Watson, Samantha M. Hill, Muhammad Noon, Raphael Gaudin, Jesse Aaron, Daoqin Tong, Denise J. Roe, Beatrice Knudsen, Ghassan Mouneimne

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Estrogen promotes growth of estrogen receptor-positive (ER+) breast tumors. However, epidemiological studies examining the prognostic characteristics of breast cancer in postmenopausal women receiving hormone replacement therapy reveal a significant decrease in tumor dissemination, suggesting that estrogen has potential protective effects against cancer cell invasion. Here, we show that estrogen suppresses invasion of ER+ breast cancer cells by increasing transcription of the Ena/VASP protein, EVL, which promotes the generation of suppressive cortical actin bundles that inhibit motility dynamics, and is crucial for the ER-mediated suppression of invasion in vitro and in vivo. Interestingly, despite its benefits in suppressing tumor growth, anti-estrogenic endocrine therapy decreases EVL expression and increases local invasion in patients. Our results highlight the dichotomous effects of estrogen on tumor progression and suggest that, in contrast to its established role in promoting growth of ER+ tumors, estrogen has a significant role in suppressing invasion through actin cytoskeletal remodeling.

Original languageEnglish (US)
Article number2980
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018
Externally publishedYes

Fingerprint

estrogens
breast
Estrogen Receptors
Actins
Tumors
Estrogens
cancer
Cells
Breast Neoplasms
tumors
Neoplasms
Growth
therapy
Hormone Replacement Therapy
Transcription
locomotion
hormones
Epidemiologic Studies
progressions
bundles

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Padilla-Rodriguez, M., Parker, S. S., Adams, D. G., Westerling, T., Puleo, J. I., Watson, A. W., ... Mouneimne, G. (2018). The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion. Nature Communications, 9(1), [2980]. https://doi.org/10.1038/s41467-018-05367-2

The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion. / Padilla-Rodriguez, Marco; Parker, Sara S.; Adams, Deanna G.; Westerling, Thomas; Puleo, Julieann I.; Watson, Adam W.; Hill, Samantha M.; Noon, Muhammad; Gaudin, Raphael; Aaron, Jesse; Tong, Daoqin; Roe, Denise J.; Knudsen, Beatrice; Mouneimne, Ghassan.

In: Nature Communications, Vol. 9, No. 1, 2980, 01.12.2018.

Research output: Contribution to journalArticle

Padilla-Rodriguez, M, Parker, SS, Adams, DG, Westerling, T, Puleo, JI, Watson, AW, Hill, SM, Noon, M, Gaudin, R, Aaron, J, Tong, D, Roe, DJ, Knudsen, B & Mouneimne, G 2018, 'The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion', Nature Communications, vol. 9, no. 1, 2980. https://doi.org/10.1038/s41467-018-05367-2
Padilla-Rodriguez, Marco ; Parker, Sara S. ; Adams, Deanna G. ; Westerling, Thomas ; Puleo, Julieann I. ; Watson, Adam W. ; Hill, Samantha M. ; Noon, Muhammad ; Gaudin, Raphael ; Aaron, Jesse ; Tong, Daoqin ; Roe, Denise J. ; Knudsen, Beatrice ; Mouneimne, Ghassan. / The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion. In: Nature Communications. 2018 ; Vol. 9, No. 1.
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