Targeting epigenetic regulations in cancer

Bo Ning, Wenyuan Li, Wei Zhao, Rongfu Wang

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Epigenetic regulation of gene expression is a dynamic and reversible process with DNA methylation, histone modifications, and chromatin remodeling. Recently, groundbreaking studies have demonstrated the importance of DNA and chromatin regulatory proteins from different aspects, including stem cell, development, and tumor genesis. Abnormal epigenetic regulation is frequently associated with diseases and drugs targeting DNA methylation and histone acetylation have been approved for cancer therapy. Although the network of epigenetic regulation is more complex than people expect, new potential druggable chromatin-associated proteins are being discovered and tested for clinical application. Here we review the key proteins that mediate epigenetic regulations through DNA methylation, the acetylation and methylation of histones, and the reader proteins that bind to modified histones. We also discuss cancer associations and recent progress of pharmacological development of these proteins.

Original languageEnglish (US)
Pages (from-to)97-109
Number of pages13
JournalActa Biochimica et Biophysica Sinica
Volume48
Issue number1
DOIs
StatePublished - May 27 2015
Externally publishedYes

Fingerprint

Epigenomics
Histones
DNA Methylation
Chromatin
Acetylation
Neoplasms
Proteins
Histone Code
Methylation
Chromatin Assembly and Disassembly
Neoplastic Stem Cells
Gene Expression Regulation
Drug Delivery Systems
Stem cells
Gene expression
Tumors
Pharmacology
DNA
Therapeutics

Keywords

  • anti-cancer drugs
  • DNA methylation
  • epigenetic regulation
  • histone modification
  • inhibitors

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

Cite this

Targeting epigenetic regulations in cancer. / Ning, Bo; Li, Wenyuan; Zhao, Wei; Wang, Rongfu.

In: Acta Biochimica et Biophysica Sinica, Vol. 48, No. 1, 27.05.2015, p. 97-109.

Research output: Contribution to journalReview article

Ning, Bo ; Li, Wenyuan ; Zhao, Wei ; Wang, Rongfu. / Targeting epigenetic regulations in cancer. In: Acta Biochimica et Biophysica Sinica. 2015 ; Vol. 48, No. 1. pp. 97-109.
@article{7153e0f58b0d48e0afbe988ab8a2ceed,
title = "Targeting epigenetic regulations in cancer",
abstract = "Epigenetic regulation of gene expression is a dynamic and reversible process with DNA methylation, histone modifications, and chromatin remodeling. Recently, groundbreaking studies have demonstrated the importance of DNA and chromatin regulatory proteins from different aspects, including stem cell, development, and tumor genesis. Abnormal epigenetic regulation is frequently associated with diseases and drugs targeting DNA methylation and histone acetylation have been approved for cancer therapy. Although the network of epigenetic regulation is more complex than people expect, new potential druggable chromatin-associated proteins are being discovered and tested for clinical application. Here we review the key proteins that mediate epigenetic regulations through DNA methylation, the acetylation and methylation of histones, and the reader proteins that bind to modified histones. We also discuss cancer associations and recent progress of pharmacological development of these proteins.",
keywords = "anti-cancer drugs, DNA methylation, epigenetic regulation, histone modification, inhibitors",
author = "Bo Ning and Wenyuan Li and Wei Zhao and Rongfu Wang",
year = "2015",
month = "5",
day = "27",
doi = "10.1093/abbs/gmv116",
language = "English (US)",
volume = "48",
pages = "97--109",
journal = "Acta Biochimica et Biophysica Sinica",
issn = "1672-9145",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Targeting epigenetic regulations in cancer

AU - Ning, Bo

AU - Li, Wenyuan

AU - Zhao, Wei

AU - Wang, Rongfu

PY - 2015/5/27

Y1 - 2015/5/27

N2 - Epigenetic regulation of gene expression is a dynamic and reversible process with DNA methylation, histone modifications, and chromatin remodeling. Recently, groundbreaking studies have demonstrated the importance of DNA and chromatin regulatory proteins from different aspects, including stem cell, development, and tumor genesis. Abnormal epigenetic regulation is frequently associated with diseases and drugs targeting DNA methylation and histone acetylation have been approved for cancer therapy. Although the network of epigenetic regulation is more complex than people expect, new potential druggable chromatin-associated proteins are being discovered and tested for clinical application. Here we review the key proteins that mediate epigenetic regulations through DNA methylation, the acetylation and methylation of histones, and the reader proteins that bind to modified histones. We also discuss cancer associations and recent progress of pharmacological development of these proteins.

AB - Epigenetic regulation of gene expression is a dynamic and reversible process with DNA methylation, histone modifications, and chromatin remodeling. Recently, groundbreaking studies have demonstrated the importance of DNA and chromatin regulatory proteins from different aspects, including stem cell, development, and tumor genesis. Abnormal epigenetic regulation is frequently associated with diseases and drugs targeting DNA methylation and histone acetylation have been approved for cancer therapy. Although the network of epigenetic regulation is more complex than people expect, new potential druggable chromatin-associated proteins are being discovered and tested for clinical application. Here we review the key proteins that mediate epigenetic regulations through DNA methylation, the acetylation and methylation of histones, and the reader proteins that bind to modified histones. We also discuss cancer associations and recent progress of pharmacological development of these proteins.

KW - anti-cancer drugs

KW - DNA methylation

KW - epigenetic regulation

KW - histone modification

KW - inhibitors

UR - http://www.scopus.com/inward/record.url?scp=84954343740&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84954343740&partnerID=8YFLogxK

U2 - 10.1093/abbs/gmv116

DO - 10.1093/abbs/gmv116

M3 - Review article

VL - 48

SP - 97

EP - 109

JO - Acta Biochimica et Biophysica Sinica

JF - Acta Biochimica et Biophysica Sinica

SN - 1672-9145

IS - 1

ER -