Systems modeling of metabolic dysregulation in neurodegenerative diseases

Priyanka Baloni, Cory C. Funk, Ben Readhead, Nathan D. Price

Research output: Contribution to journalReview articlepeer-review

Abstract

Neurodegenerative diseases (NDDs) encompass a wide range of conditions that arise owing to progressive degeneration and the ultimate loss of nerve cells in the brain and peripheral nervous system. NDDs such as Alzheimer's, Parkinson's, and Huntington's diseases negatively impact both length and quality of life, due to lack of effective disease-modifying treatments. Herein, we review the use of genome-scale metabolic models, network-based approaches, and integration with multiomics data to identify key biological processes that characterize NDDs. We describe powerful systems biology approaches for modeling NDD pathophysiology by leveraging in silico models that are informed by patient-derived multiomics data. These approaches can enable mechanistic insights into NDD-specific metabolic dysregulations that can be leveraged to identify potential metabolic markers of disease and predisease states.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalCurrent Opinion in Pharmacology
Volume60
DOIs
StatePublished - Oct 2021
Externally publishedYes

Keywords

  • Neurodegenerative diseases, Metabolic modeling, Multiomics analysis, Network approaches

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Fingerprint

Dive into the research topics of 'Systems modeling of metabolic dysregulation in neurodegenerative diseases'. Together they form a unique fingerprint.

Cite this