Synthesis of water-soluble sugar derivatives of combretastatin A-4

Richard T. Brown, Brian W. Fox, John A. Hadfield, Alan T. McGown, Stephen P. Mayalarp, George Pettit, Julie A. Woods

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Three sugar derivatives (6, 7 and 13) of the antimitotic agent combretastatin A-4 1 have been synthesized. Two of these water-soluble derivatives (6,13) showed strong cytotoxicity to the murine P388 cell line.

Original languageEnglish (US)
Pages (from-to)577-581
Number of pages5
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number5
StatePublished - Dec 1 1995

ASJC Scopus subject areas

  • Chemistry(all)

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