Synthesis of water-soluble sugar derivatives of combretastatin A-4

Richard T. Brown, Brian W. Fox, John A. Hadfield, Alan T. McGown, Stephen P. Mayalarp, George Pettit, Julie A. Woods

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30 Scopus citations

Abstract

Three sugar derivatives (6, 7 and 13) of the antimitotic agent combretastatin A-4 1 have been synthesized. Two of these water-soluble derivatives (6,13) showed strong cytotoxicity to the murine P388 cell line.

Original languageEnglish (US)
Pages (from-to)577-581
Number of pages5
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number5
StatePublished - Dec 1 1995

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ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Brown, R. T., Fox, B. W., Hadfield, J. A., McGown, A. T., Mayalarp, S. P., Pettit, G., & Woods, J. A. (1995). Synthesis of water-soluble sugar derivatives of combretastatin A-4. Journal of the Chemical Society, Perkin Transactions 1, (5), 577-581.