Synthesis of water-soluble sugar derivatives of combretastatin A-4

Richard T. Brown; Brian W. Fox; John A. Hadfield; Alan T. McGown; Stephen P. Mayalarp; George Pettit; Julie A. Woods

Synthesis of water-soluble sugar derivatives of combretastatin A-4

Richard T. Brown, Brian W. Fox, John A. Hadfield, Alan T. McGown, Stephen P. Mayalarp, George Pettit, Julie A. Woods

Research output: Contribution to journal › Article › peer-review

Abstract

Three sugar derivatives (6, 7 and 13) of the antimitotic agent combretastatin A-4 1 have been synthesized. Two of these water-soluble derivatives (6,13) showed strong cytotoxicity to the murine P388 cell line.

Original language	English (US)
Pages (from-to)	577-581
Number of pages	5
Journal	Journal of the Chemical Society, Perkin Transactions 1
Issue number	5
State	Published - Dec 1 1995

ASJC Scopus subject areas

General Chemistry

Cite this

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title = "Synthesis of water-soluble sugar derivatives of combretastatin A-4",

abstract = "Three sugar derivatives (6, 7 and 13) of the antimitotic agent combretastatin A-4 1 have been synthesized. Two of these water-soluble derivatives (6,13) showed strong cytotoxicity to the murine P388 cell line.",

author = "Brown, {Richard T.} and Fox, {Brian W.} and Hadfield, {John A.} and McGown, {Alan T.} and Mayalarp, {Stephen P.} and George Pettit and Woods, {Julie A.}",

year = "1995",

month = dec,

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language = "English (US)",

pages = "577--581",

journal = "Journal of the Chemical Society, Perkin Transactions 1",

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T1 - Synthesis of water-soluble sugar derivatives of combretastatin A-4

AU - Brown, Richard T.

AU - Fox, Brian W.

AU - Hadfield, John A.

AU - McGown, Alan T.

AU - Mayalarp, Stephen P.

AU - Pettit, George

AU - Woods, Julie A.

PY - 1995/12/1

Y1 - 1995/12/1

N2 - Three sugar derivatives (6, 7 and 13) of the antimitotic agent combretastatin A-4 1 have been synthesized. Two of these water-soluble derivatives (6,13) showed strong cytotoxicity to the murine P388 cell line.

AB - Three sugar derivatives (6, 7 and 13) of the antimitotic agent combretastatin A-4 1 have been synthesized. Two of these water-soluble derivatives (6,13) showed strong cytotoxicity to the murine P388 cell line.

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M3 - Article

AN - SCOPUS:37049074864

SN - 1472-7781

SP - 577

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JO - Journal of the Chemical Society, Perkin Transactions 1

JF - Journal of the Chemical Society, Perkin Transactions 1

IS - 5

ER -

Synthesis of water-soluble sugar derivatives of combretastatin A-4

Abstract

ASJC Scopus subject areas

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