Synthesis of hybrid gold/iron oxide nanoparticles in block copolymer micelles for imaging, drug delivery, and magnetic hyperthermia

Dong Hyun Kim, Elena A. Rozhkova, Tijana Rajh, Samuel D. Bader, Valentyn Novosad

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

In our study, hybrid gold/iron oxide loaded thermoresponsive micelles were synthesized for combined hyperthermia and chemotherapy, and optical imaging. Polymeric micelles made of amphiphilic block copolymer of poly(N- isopropylacrylamide-co-acry-lamide)-block-poly(ε-caprolactone) were conjugated with gold/iron oxide particles which are self-assembled at the hydrophobic polymer core. Thermal sensitivity and magnetic and optical properties of the hybrid gold/iron oxide micelles were investigated for the combined therapy and optical imaging.

Original languageEnglish (US)
Article number5257027
Pages (from-to)4821-4824
Number of pages4
JournalIEEE Transactions on Magnetics
Volume45
Issue number10
DOIs
StatePublished - Oct 2009
Externally publishedYes

Keywords

  • Drug delivery
  • Gold nanoparticles
  • Hybrid nanoparticles
  • Hyperthermia
  • Magnetic nanoparticles

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

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