Synthesis of hybrid gold/iron oxide nanoparticles in block copolymer micelles for imaging, drug delivery, and magnetic hyperthermia

Dong Hyun Kim; Elena A. Rozhkova; Tijana Rajh; Samuel D. Bader; Valentyn Novosad

doi:10.1109/TMAG.2009.2024000

Synthesis of hybrid gold/iron oxide nanoparticles in block copolymer micelles for imaging, drug delivery, and magnetic hyperthermia

Dong Hyun Kim, Elena A. Rozhkova, Tijana Rajh, Samuel D. Bader, Valentyn Novosad

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

In our study, hybrid gold/iron oxide loaded thermoresponsive micelles were synthesized for combined hyperthermia and chemotherapy, and optical imaging. Polymeric micelles made of amphiphilic block copolymer of poly(N- isopropylacrylamide-co-acry-lamide)-block-poly(ε-caprolactone) were conjugated with gold/iron oxide particles which are self-assembled at the hydrophobic polymer core. Thermal sensitivity and magnetic and optical properties of the hybrid gold/iron oxide micelles were investigated for the combined therapy and optical imaging.

Original language	English (US)
Article number	5257027
Pages (from-to)	4821-4824
Number of pages	4
Journal	IEEE Transactions on Magnetics
Volume	45
Issue number	10
DOIs	https://doi.org/10.1109/TMAG.2009.2024000
State	Published - Oct 2009
Externally published	Yes

Keywords

Drug delivery
Gold nanoparticles
Hybrid nanoparticles
Hyperthermia
Magnetic nanoparticles

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Electrical and Electronic Engineering

Access to Document

10.1109/TMAG.2009.2024000

Cite this

@article{5453dc30afe44133be35c11f059f02d2,

title = "Synthesis of hybrid gold/iron oxide nanoparticles in block copolymer micelles for imaging, drug delivery, and magnetic hyperthermia",

abstract = "In our study, hybrid gold/iron oxide loaded thermoresponsive micelles were synthesized for combined hyperthermia and chemotherapy, and optical imaging. Polymeric micelles made of amphiphilic block copolymer of poly(N- isopropylacrylamide-co-acry-lamide)-block-poly(ε-caprolactone) were conjugated with gold/iron oxide particles which are self-assembled at the hydrophobic polymer core. Thermal sensitivity and magnetic and optical properties of the hybrid gold/iron oxide micelles were investigated for the combined therapy and optical imaging.",

keywords = "Drug delivery, Gold nanoparticles, Hybrid nanoparticles, Hyperthermia, Magnetic nanoparticles",

author = "Kim, {Dong Hyun} and Rozhkova, {Elena A.} and Tijana Rajh and Bader, {Samuel D.} and Valentyn Novosad",

note = "Funding Information: This work as well as the use of the Center for Nanoscale Materials at Argonne National Laboratory and the Electron Microscopy Center was supported by UChicago Argonne, LLC, Operator of Argonne National Laboratory (“Argonne”). Argonne, a U.S. Department of Energy Office of Science laboratory, is operated under Contract DE-AC02-06CH11357. The authors would like to thank the Nanofabrication and NanoBio Interfaces group at the CNM, under User Proposal No. 704 for technical support.",

year = "2009",

month = oct,

doi = "10.1109/TMAG.2009.2024000",

language = "English (US)",

volume = "45",

pages = "4821--4824",

journal = "IEEE Transactions on Magnetics",

issn = "0018-9464",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

number = "10",

}

TY - JOUR

T1 - Synthesis of hybrid gold/iron oxide nanoparticles in block copolymer micelles for imaging, drug delivery, and magnetic hyperthermia

AU - Kim, Dong Hyun

AU - Rozhkova, Elena A.

AU - Rajh, Tijana

AU - Bader, Samuel D.

AU - Novosad, Valentyn

N1 - Funding Information: This work as well as the use of the Center for Nanoscale Materials at Argonne National Laboratory and the Electron Microscopy Center was supported by UChicago Argonne, LLC, Operator of Argonne National Laboratory (“Argonne”). Argonne, a U.S. Department of Energy Office of Science laboratory, is operated under Contract DE-AC02-06CH11357. The authors would like to thank the Nanofabrication and NanoBio Interfaces group at the CNM, under User Proposal No. 704 for technical support.

PY - 2009/10

Y1 - 2009/10

N2 - In our study, hybrid gold/iron oxide loaded thermoresponsive micelles were synthesized for combined hyperthermia and chemotherapy, and optical imaging. Polymeric micelles made of amphiphilic block copolymer of poly(N- isopropylacrylamide-co-acry-lamide)-block-poly(ε-caprolactone) were conjugated with gold/iron oxide particles which are self-assembled at the hydrophobic polymer core. Thermal sensitivity and magnetic and optical properties of the hybrid gold/iron oxide micelles were investigated for the combined therapy and optical imaging.

AB - In our study, hybrid gold/iron oxide loaded thermoresponsive micelles were synthesized for combined hyperthermia and chemotherapy, and optical imaging. Polymeric micelles made of amphiphilic block copolymer of poly(N- isopropylacrylamide-co-acry-lamide)-block-poly(ε-caprolactone) were conjugated with gold/iron oxide particles which are self-assembled at the hydrophobic polymer core. Thermal sensitivity and magnetic and optical properties of the hybrid gold/iron oxide micelles were investigated for the combined therapy and optical imaging.

KW - Drug delivery

KW - Gold nanoparticles

KW - Hybrid nanoparticles

KW - Hyperthermia

KW - Magnetic nanoparticles

UR - http://www.scopus.com/inward/record.url?scp=70350578832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350578832&partnerID=8YFLogxK

U2 - 10.1109/TMAG.2009.2024000

DO - 10.1109/TMAG.2009.2024000

M3 - Article

AN - SCOPUS:70350578832

SN - 0018-9464

VL - 45

SP - 4821

EP - 4824

JO - IEEE Transactions on Magnetics

JF - IEEE Transactions on Magnetics

IS - 10

M1 - 5257027

ER -

Synthesis of hybrid gold/iron oxide nanoparticles in block copolymer micelles for imaging, drug delivery, and magnetic hyperthermia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this