Synthesis and characterization of thermo-sensitive radio-opaque poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate)

Bae Hoon Lee, Christine Leon, Ryan McLemore, Jorge Valdez MacIas, Brent Vernon

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Radiopacity is required for embolic materials to be monitored by angiography during embolization. Covalently bound radio-opaque biomaterials would be ideal for embolization. Poly(N-isopropylacrylamide-co-PEG-acrylate) modified with 2-iodobenzoyl chloride was synthesized and characterized by 1H-NMR, differential scanning calorimetry and X-ray opacity. Poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate) shows radiopacity, as well as thermo-sensitivity. Cytotoxicity testing on these co-polymers shows little cytotoxicity. Phase-transition temperature and radiopacity varied according to the content of NIPAAm and 2-iodobenzoate. Increasing the content of 2-iodobenzoate raised the radiopacity and lowered the LCST.

Original languageEnglish (US)
Pages (from-to)2357-2367
Number of pages11
JournalJournal of Biomaterials Science, Polymer Edition
Volume22
Issue number17
DOIs
StatePublished - 2011

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Keywords

  • NIPAAm
  • Radio-opacity
  • thermo-responsive polymers

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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