Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines

Mark A. Elban; Jean Chapuis; Mei Li; Sidney Hecht

doi:10.1016/j.bmc.2007.06.035

Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines

Mark A. Elban, Jean Chapuis, Mei Li, Sidney Hecht

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Described herein is the first total synthesis and structural confirmation of cepharadione A, a naturally occurring DNA damaging agent. Also reported is the synthesis of cepharadione B, a closely related natural product, as well as the biological evaluation of both natural products. Finally, the preparation and biological evaluation of novel dioxoaporphine analogues is described.

Original language	English (US)
Pages (from-to)	6119-6125
Number of pages	7
Journal	Bioorganic and Medicinal Chemistry
Volume	15
Issue number	18
DOIs	https://doi.org/10.1016/j.bmc.2007.06.035
State	Published - Sep 15 2007

Keywords

Cepharadiones A and B
Cytotoxicity
Oxoaporphines
Suzuki coupling

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmc.2007.06.035

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title = "Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines",

abstract = "Described herein is the first total synthesis and structural confirmation of cepharadione A, a naturally occurring DNA damaging agent. Also reported is the synthesis of cepharadione B, a closely related natural product, as well as the biological evaluation of both natural products. Finally, the preparation and biological evaluation of novel dioxoaporphine analogues is described.",

keywords = "Cepharadiones A and B, Cytotoxicity, Oxoaporphines, Suzuki coupling",

author = "Elban, {Mark A.} and Jean Chapuis and Mei Li and Sidney Hecht",

note = "Funding Information: This work was supported by NIH Research Grant CA50771, awarded by the National Cancer Institute.",

year = "2007",

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doi = "10.1016/j.bmc.2007.06.035",

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TY - JOUR

T1 - Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines

AU - Elban, Mark A.

AU - Chapuis, Jean

AU - Li, Mei

AU - Hecht, Sidney

N1 - Funding Information: This work was supported by NIH Research Grant CA50771, awarded by the National Cancer Institute.

PY - 2007/9/15

Y1 - 2007/9/15

N2 - Described herein is the first total synthesis and structural confirmation of cepharadione A, a naturally occurring DNA damaging agent. Also reported is the synthesis of cepharadione B, a closely related natural product, as well as the biological evaluation of both natural products. Finally, the preparation and biological evaluation of novel dioxoaporphine analogues is described.

AB - Described herein is the first total synthesis and structural confirmation of cepharadione A, a naturally occurring DNA damaging agent. Also reported is the synthesis of cepharadione B, a closely related natural product, as well as the biological evaluation of both natural products. Finally, the preparation and biological evaluation of novel dioxoaporphine analogues is described.

KW - Cepharadiones A and B

KW - Cytotoxicity

KW - Oxoaporphines

KW - Suzuki coupling

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UR - http://www.scopus.com/inward/citedby.url?scp=34447629723&partnerID=8YFLogxK

U2 - 10.1016/j.bmc.2007.06.035

DO - 10.1016/j.bmc.2007.06.035

M3 - Article

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AN - SCOPUS:34447629723

SN - 0968-0896

VL - 15

SP - 6119

EP - 6125

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 18

ER -

Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines

Abstract

Keywords

ASJC Scopus subject areas

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