Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines

Mark A. Elban, Jean Chapuis, Mei Li, Sidney Hecht

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Described herein is the first total synthesis and structural confirmation of cepharadione A, a naturally occurring DNA damaging agent. Also reported is the synthesis of cepharadione B, a closely related natural product, as well as the biological evaluation of both natural products. Finally, the preparation and biological evaluation of novel dioxoaporphine analogues is described.

Original languageEnglish (US)
Pages (from-to)6119-6125
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume15
Issue number18
DOIs
StatePublished - Sep 15 2007

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Keywords

  • Cepharadiones A and B
  • Cytotoxicity
  • Oxoaporphines
  • Suzuki coupling

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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