TY - JOUR
T1 - Synchrotron-based X-ray in-situ imaging techniques for advancing the understanding of pharmaceutical granulation
AU - Li, Chen
AU - Zhu, Ning
AU - Emady, Heather N.
AU - Zhang, Lifeng
PY - 2019/12/15
Y1 - 2019/12/15
N2 - Wet granulation of powders is a key unit operation in the pharmaceutical industry. Due to the complexity of the granulation process taking place in a short time, observing and measuring the granulation process is challenging with conventional experimental methods. In this study, synchrotron-based X-ray imaging techniques were, for the first time, employed to capture the dynamic granulation process with a single drop impacting method in pharmaceutical powder beds. Five common pharmaceutical excipients, two active pharmaceutical ingredients (APIs) and their mixtures were used as the powder beds. The dynamic interaction between the liquid binder and solid powders were observed from high resolution X-ray images captured. Results show that pharmaceutical powder properties, including particle size, hydrophilicity, and morphology, have significant influence on the dynamic granulation process and the final granular product.
AB - Wet granulation of powders is a key unit operation in the pharmaceutical industry. Due to the complexity of the granulation process taking place in a short time, observing and measuring the granulation process is challenging with conventional experimental methods. In this study, synchrotron-based X-ray imaging techniques were, for the first time, employed to capture the dynamic granulation process with a single drop impacting method in pharmaceutical powder beds. Five common pharmaceutical excipients, two active pharmaceutical ingredients (APIs) and their mixtures were used as the powder beds. The dynamic interaction between the liquid binder and solid powders were observed from high resolution X-ray images captured. Results show that pharmaceutical powder properties, including particle size, hydrophilicity, and morphology, have significant influence on the dynamic granulation process and the final granular product.
KW - Granulation
KW - Nucleation
KW - Pharmaceutical powders
KW - Synchrotron
KW - X-ray imaging
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U2 - 10.1016/j.ijpharm.2019.118797
DO - 10.1016/j.ijpharm.2019.118797
M3 - Article
C2 - 31678383
AN - SCOPUS:85075432559
SN - 0378-5173
VL - 572
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
M1 - 118797
ER -