Synchrotron-based X-ray in-situ imaging techniques for advancing the understanding of pharmaceutical granulation

Chen Li, Ning Zhu, Heather N. Emady, Lifeng Zhang

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Wet granulation of powders is a key unit operation in the pharmaceutical industry. Due to the complexity of the granulation process taking place in a short time, observing and measuring the granulation process is challenging with conventional experimental methods. In this study, synchrotron-based X-ray imaging techniques were, for the first time, employed to capture the dynamic granulation process with a single drop impacting method in pharmaceutical powder beds. Five common pharmaceutical excipients, two active pharmaceutical ingredients (APIs) and their mixtures were used as the powder beds. The dynamic interaction between the liquid binder and solid powders were observed from high resolution X-ray images captured. Results show that pharmaceutical powder properties, including particle size, hydrophilicity, and morphology, have significant influence on the dynamic granulation process and the final granular product.

Original languageEnglish (US)
Article number118797
JournalInternational Journal of Pharmaceutics
Volume572
DOIs
StatePublished - Dec 15 2019

Keywords

  • Granulation
  • Nucleation
  • Pharmaceutical powders
  • Synchrotron
  • X-ray imaging

ASJC Scopus subject areas

  • Pharmaceutical Science

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