Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

Jialiang Yang, Tao Huang, Francesca Petralia, Quan Long, Bin Zhang, Carmen Argmann, Yong Zhao, Charles V. Mobbs, Eric E. Schadt, Jun Zhu, Zhidong Tu, Kristin G. Ardlie, David S. Deluca, Ayellet V. Segrè, Timothy J. Sullivan, Taylor R. Young, Ellen T. Gelfand, Casandra A. Trowbridge, Julian B. Maller, Taru TukiainenMonkol Lek, Lucas D. Ward, Pouya Kheradpour, Benjamin Iriarte, Yan Meng, Cameron D. Palmer, Wendy Winckler, Joel Hirschhorn, Manolis Kellis, Daniel G. MacArthur, Gad Getz, Andrey A. Shablin, Gen Li, Yi Hui Zhou, Andrew B. Nobel, Ivan Rusyn, Fred A. Wright, Tuuli Lappalainen, Pedro G. Ferreira, Halit Ongen, Manuel A. Rivas, Alexis Battle, Sara Mostafavi, Jean Monlong, Michael Sammeth, Marta Mele, Ferran Reverter, Jakob Goldman, Daphne Koller, Roderic Guigo, Mark I. McCarthy, Emmanouil T. Dermitzakis, Eric R. Gamazon, Anuar Konkashbaev, Dan L. Nicolae, Nancy J. Cox, Timothée Flutre, Xiaoquan Wen, Matthew Stephens, Jonathan K. Pritchard, Luan Lin, Jun Liu, Amanda Brown, Bernadette Mestichelli, Denee Tidwell, Edmund Lo, Mike Salvatore, Saboor Shad, Jeffrey A. Thomas, John T. Lonsdale, Christopher Choi, Ellen Karasik, Kimberly Ramsey, Michael T. Moser, Barbara A. Foster, Bryan M. Gillard, John Syron, Johnelle Fleming, Harold Magazine, Rick Hasz, Gary D. Walters, Jason P. Bridge, Mark Miklos, Susan Sullivan, Laura K. Barker, Heather Traino, Magboeba Mosavel, Laura A. Siminoff, Dana R. Valley, Daniel C. Rohrer, Scott Jewel, Philip Branton, Leslie H. Sobin, Liqun Qi, Pushpa Hariharan, Shenpei Wu, David Tabor, Charles Shive, Anna M. Smith, Stephen A. Buia, Anita H. Undale, Karna L. Robinson, Nancy Roche, Kimberly M. Valentino, Angela Britton, Robin Burges, Debra Bradbury, Kenneth W. Hambright, John Seleski, Greg E. Korzeniewski, Kenyon Erickson, Yvonne Marcus, Jorge Tejada, Mehran Taherian, Chunrong Lu, Barnaby E. Robles, Margaret Basile, Deborah C. Mash, Simona Volpi, Jeff Struewing, Gary F. Temple, Joy Boyer, Deborah Colantuoni, Roger Little, Susan Koester, Latarsha J. Carithers, Helen M. Moore, Ping Guan, Carolyn Compton, Sherilyn J. Sawyer, Joanne P. Demchok, Jimmie B. Vaught, Chana A. Rabiner, Nicole C. Lockhart

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Aging is one of the most important biological processes and is a known risk factor for many age-related diseases in human. Studying age-related transcriptomic changes in tissues across the whole body can provide valuable information for a holistic understanding of this fundamental process. In this work, we catalogue age-related gene expression changes in nine tissues from nearly two hundred individuals collected by the Genotype-Tissue Expression (GTEx) project. In general, we find the aging gene expression signatures are very tissue specific. However, enrichment for some well-known aging components such as mitochondria biology is observed in many tissues. Different levels of cross-tissue synchronization of age-related gene expression changes are observed, and some essential tissues (e.g., heart and lung) show much stronger "co-aging" than other tissues based on a principal component analysis. The aging gene signatures and complex disease genes show a complex overlapping pattern and only in some cases, we see that they are significantly overlapped in the tissues affected by the corresponding diseases. In summary, our analyses provide novel insights to the co-regulation of age-related gene expression in multiple tissues; it also presents a tissue-specific view of the link between aging and age-related diseases.

Original languageEnglish (US)
Article number15145
JournalScientific Reports
Volume5
DOIs
StatePublished - Oct 19 2015
Externally publishedYes

Fingerprint

Gene Expression
Biological Phenomena
Principal Component Analysis
Transcriptome
Genes
Mitochondria
Genotype
Lung

ASJC Scopus subject areas

  • General

Cite this

Yang, J., Huang, T., Petralia, F., Long, Q., Zhang, B., Argmann, C., ... Lockhart, N. C. (2015). Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases. Scientific Reports, 5, [15145]. https://doi.org/10.1038/srep15145

Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases. / Yang, Jialiang; Huang, Tao; Petralia, Francesca; Long, Quan; Zhang, Bin; Argmann, Carmen; Zhao, Yong; Mobbs, Charles V.; Schadt, Eric E.; Zhu, Jun; Tu, Zhidong; Ardlie, Kristin G.; Deluca, David S.; Segrè, Ayellet V.; Sullivan, Timothy J.; Young, Taylor R.; Gelfand, Ellen T.; Trowbridge, Casandra A.; Maller, Julian B.; Tukiainen, Taru; Lek, Monkol; Ward, Lucas D.; Kheradpour, Pouya; Iriarte, Benjamin; Meng, Yan; Palmer, Cameron D.; Winckler, Wendy; Hirschhorn, Joel; Kellis, Manolis; MacArthur, Daniel G.; Getz, Gad; Shablin, Andrey A.; Li, Gen; Zhou, Yi Hui; Nobel, Andrew B.; Rusyn, Ivan; Wright, Fred A.; Lappalainen, Tuuli; Ferreira, Pedro G.; Ongen, Halit; Rivas, Manuel A.; Battle, Alexis; Mostafavi, Sara; Monlong, Jean; Sammeth, Michael; Mele, Marta; Reverter, Ferran; Goldman, Jakob; Koller, Daphne; Guigo, Roderic; McCarthy, Mark I.; Dermitzakis, Emmanouil T.; Gamazon, Eric R.; Konkashbaev, Anuar; Nicolae, Dan L.; Cox, Nancy J.; Flutre, Timothée; Wen, Xiaoquan; Stephens, Matthew; Pritchard, Jonathan K.; Lin, Luan; Liu, Jun; Brown, Amanda; Mestichelli, Bernadette; Tidwell, Denee; Lo, Edmund; Salvatore, Mike; Shad, Saboor; Thomas, Jeffrey A.; Lonsdale, John T.; Choi, Christopher; Karasik, Ellen; Ramsey, Kimberly; Moser, Michael T.; Foster, Barbara A.; Gillard, Bryan M.; Syron, John; Fleming, Johnelle; Magazine, Harold; Hasz, Rick; Walters, Gary D.; Bridge, Jason P.; Miklos, Mark; Sullivan, Susan; Barker, Laura K.; Traino, Heather; Mosavel, Magboeba; Siminoff, Laura A.; Valley, Dana R.; Rohrer, Daniel C.; Jewel, Scott; Branton, Philip; Sobin, Leslie H.; Qi, Liqun; Hariharan, Pushpa; Wu, Shenpei; Tabor, David; Shive, Charles; Smith, Anna M.; Buia, Stephen A.; Undale, Anita H.; Robinson, Karna L.; Roche, Nancy; Valentino, Kimberly M.; Britton, Angela; Burges, Robin; Bradbury, Debra; Hambright, Kenneth W.; Seleski, John; Korzeniewski, Greg E.; Erickson, Kenyon; Marcus, Yvonne; Tejada, Jorge; Taherian, Mehran; Lu, Chunrong; Robles, Barnaby E.; Basile, Margaret; Mash, Deborah C.; Volpi, Simona; Struewing, Jeff; Temple, Gary F.; Boyer, Joy; Colantuoni, Deborah; Little, Roger; Koester, Susan; Carithers, Latarsha J.; Moore, Helen M.; Guan, Ping; Compton, Carolyn; Sawyer, Sherilyn J.; Demchok, Joanne P.; Vaught, Jimmie B.; Rabiner, Chana A.; Lockhart, Nicole C.

In: Scientific Reports, Vol. 5, 15145, 19.10.2015.

Research output: Contribution to journalArticle

Yang, J, Huang, T, Petralia, F, Long, Q, Zhang, B, Argmann, C, Zhao, Y, Mobbs, CV, Schadt, EE, Zhu, J, Tu, Z, Ardlie, KG, Deluca, DS, Segrè, AV, Sullivan, TJ, Young, TR, Gelfand, ET, Trowbridge, CA, Maller, JB, Tukiainen, T, Lek, M, Ward, LD, Kheradpour, P, Iriarte, B, Meng, Y, Palmer, CD, Winckler, W, Hirschhorn, J, Kellis, M, MacArthur, DG, Getz, G, Shablin, AA, Li, G, Zhou, YH, Nobel, AB, Rusyn, I, Wright, FA, Lappalainen, T, Ferreira, PG, Ongen, H, Rivas, MA, Battle, A, Mostafavi, S, Monlong, J, Sammeth, M, Mele, M, Reverter, F, Goldman, J, Koller, D, Guigo, R, McCarthy, MI, Dermitzakis, ET, Gamazon, ER, Konkashbaev, A, Nicolae, DL, Cox, NJ, Flutre, T, Wen, X, Stephens, M, Pritchard, JK, Lin, L, Liu, J, Brown, A, Mestichelli, B, Tidwell, D, Lo, E, Salvatore, M, Shad, S, Thomas, JA, Lonsdale, JT, Choi, C, Karasik, E, Ramsey, K, Moser, MT, Foster, BA, Gillard, BM, Syron, J, Fleming, J, Magazine, H, Hasz, R, Walters, GD, Bridge, JP, Miklos, M, Sullivan, S, Barker, LK, Traino, H, Mosavel, M, Siminoff, LA, Valley, DR, Rohrer, DC, Jewel, S, Branton, P, Sobin, LH, Qi, L, Hariharan, P, Wu, S, Tabor, D, Shive, C, Smith, AM, Buia, SA, Undale, AH, Robinson, KL, Roche, N, Valentino, KM, Britton, A, Burges, R, Bradbury, D, Hambright, KW, Seleski, J, Korzeniewski, GE, Erickson, K, Marcus, Y, Tejada, J, Taherian, M, Lu, C, Robles, BE, Basile, M, Mash, DC, Volpi, S, Struewing, J, Temple, GF, Boyer, J, Colantuoni, D, Little, R, Koester, S, Carithers, LJ, Moore, HM, Guan, P, Compton, C, Sawyer, SJ, Demchok, JP, Vaught, JB, Rabiner, CA & Lockhart, NC 2015, 'Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases', Scientific Reports, vol. 5, 15145. https://doi.org/10.1038/srep15145
Yang, Jialiang ; Huang, Tao ; Petralia, Francesca ; Long, Quan ; Zhang, Bin ; Argmann, Carmen ; Zhao, Yong ; Mobbs, Charles V. ; Schadt, Eric E. ; Zhu, Jun ; Tu, Zhidong ; Ardlie, Kristin G. ; Deluca, David S. ; Segrè, Ayellet V. ; Sullivan, Timothy J. ; Young, Taylor R. ; Gelfand, Ellen T. ; Trowbridge, Casandra A. ; Maller, Julian B. ; Tukiainen, Taru ; Lek, Monkol ; Ward, Lucas D. ; Kheradpour, Pouya ; Iriarte, Benjamin ; Meng, Yan ; Palmer, Cameron D. ; Winckler, Wendy ; Hirschhorn, Joel ; Kellis, Manolis ; MacArthur, Daniel G. ; Getz, Gad ; Shablin, Andrey A. ; Li, Gen ; Zhou, Yi Hui ; Nobel, Andrew B. ; Rusyn, Ivan ; Wright, Fred A. ; Lappalainen, Tuuli ; Ferreira, Pedro G. ; Ongen, Halit ; Rivas, Manuel A. ; Battle, Alexis ; Mostafavi, Sara ; Monlong, Jean ; Sammeth, Michael ; Mele, Marta ; Reverter, Ferran ; Goldman, Jakob ; Koller, Daphne ; Guigo, Roderic ; McCarthy, Mark I. ; Dermitzakis, Emmanouil T. ; Gamazon, Eric R. ; Konkashbaev, Anuar ; Nicolae, Dan L. ; Cox, Nancy J. ; Flutre, Timothée ; Wen, Xiaoquan ; Stephens, Matthew ; Pritchard, Jonathan K. ; Lin, Luan ; Liu, Jun ; Brown, Amanda ; Mestichelli, Bernadette ; Tidwell, Denee ; Lo, Edmund ; Salvatore, Mike ; Shad, Saboor ; Thomas, Jeffrey A. ; Lonsdale, John T. ; Choi, Christopher ; Karasik, Ellen ; Ramsey, Kimberly ; Moser, Michael T. ; Foster, Barbara A. ; Gillard, Bryan M. ; Syron, John ; Fleming, Johnelle ; Magazine, Harold ; Hasz, Rick ; Walters, Gary D. ; Bridge, Jason P. ; Miklos, Mark ; Sullivan, Susan ; Barker, Laura K. ; Traino, Heather ; Mosavel, Magboeba ; Siminoff, Laura A. ; Valley, Dana R. ; Rohrer, Daniel C. ; Jewel, Scott ; Branton, Philip ; Sobin, Leslie H. ; Qi, Liqun ; Hariharan, Pushpa ; Wu, Shenpei ; Tabor, David ; Shive, Charles ; Smith, Anna M. ; Buia, Stephen A. ; Undale, Anita H. ; Robinson, Karna L. ; Roche, Nancy ; Valentino, Kimberly M. ; Britton, Angela ; Burges, Robin ; Bradbury, Debra ; Hambright, Kenneth W. ; Seleski, John ; Korzeniewski, Greg E. ; Erickson, Kenyon ; Marcus, Yvonne ; Tejada, Jorge ; Taherian, Mehran ; Lu, Chunrong ; Robles, Barnaby E. ; Basile, Margaret ; Mash, Deborah C. ; Volpi, Simona ; Struewing, Jeff ; Temple, Gary F. ; Boyer, Joy ; Colantuoni, Deborah ; Little, Roger ; Koester, Susan ; Carithers, Latarsha J. ; Moore, Helen M. ; Guan, Ping ; Compton, Carolyn ; Sawyer, Sherilyn J. ; Demchok, Joanne P. ; Vaught, Jimmie B. ; Rabiner, Chana A. ; Lockhart, Nicole C. / Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases. In: Scientific Reports. 2015 ; Vol. 5.
@article{70211c008c844e89abe59b8df76badd6,
title = "Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases",
abstract = "Aging is one of the most important biological processes and is a known risk factor for many age-related diseases in human. Studying age-related transcriptomic changes in tissues across the whole body can provide valuable information for a holistic understanding of this fundamental process. In this work, we catalogue age-related gene expression changes in nine tissues from nearly two hundred individuals collected by the Genotype-Tissue Expression (GTEx) project. In general, we find the aging gene expression signatures are very tissue specific. However, enrichment for some well-known aging components such as mitochondria biology is observed in many tissues. Different levels of cross-tissue synchronization of age-related gene expression changes are observed, and some essential tissues (e.g., heart and lung) show much stronger {"}co-aging{"} than other tissues based on a principal component analysis. The aging gene signatures and complex disease genes show a complex overlapping pattern and only in some cases, we see that they are significantly overlapped in the tissues affected by the corresponding diseases. In summary, our analyses provide novel insights to the co-regulation of age-related gene expression in multiple tissues; it also presents a tissue-specific view of the link between aging and age-related diseases.",
author = "Jialiang Yang and Tao Huang and Francesca Petralia and Quan Long and Bin Zhang and Carmen Argmann and Yong Zhao and Mobbs, {Charles V.} and Schadt, {Eric E.} and Jun Zhu and Zhidong Tu and Ardlie, {Kristin G.} and Deluca, {David S.} and Segr{\`e}, {Ayellet V.} and Sullivan, {Timothy J.} and Young, {Taylor R.} and Gelfand, {Ellen T.} and Trowbridge, {Casandra A.} and Maller, {Julian B.} and Taru Tukiainen and Monkol Lek and Ward, {Lucas D.} and Pouya Kheradpour and Benjamin Iriarte and Yan Meng and Palmer, {Cameron D.} and Wendy Winckler and Joel Hirschhorn and Manolis Kellis and MacArthur, {Daniel G.} and Gad Getz and Shablin, {Andrey A.} and Gen Li and Zhou, {Yi Hui} and Nobel, {Andrew B.} and Ivan Rusyn and Wright, {Fred A.} and Tuuli Lappalainen and Ferreira, {Pedro G.} and Halit Ongen and Rivas, {Manuel A.} and Alexis Battle and Sara Mostafavi and Jean Monlong and Michael Sammeth and Marta Mele and Ferran Reverter and Jakob Goldman and Daphne Koller and Roderic Guigo and McCarthy, {Mark I.} and Dermitzakis, {Emmanouil T.} and Gamazon, {Eric R.} and Anuar Konkashbaev and Nicolae, {Dan L.} and Cox, {Nancy J.} and Timoth{\'e}e Flutre and Xiaoquan Wen and Matthew Stephens and Pritchard, {Jonathan K.} and Luan Lin and Jun Liu and Amanda Brown and Bernadette Mestichelli and Denee Tidwell and Edmund Lo and Mike Salvatore and Saboor Shad and Thomas, {Jeffrey A.} and Lonsdale, {John T.} and Christopher Choi and Ellen Karasik and Kimberly Ramsey and Moser, {Michael T.} and Foster, {Barbara A.} and Gillard, {Bryan M.} and John Syron and Johnelle Fleming and Harold Magazine and Rick Hasz and Walters, {Gary D.} and Bridge, {Jason P.} and Mark Miklos and Susan Sullivan and Barker, {Laura K.} and Heather Traino and Magboeba Mosavel and Siminoff, {Laura A.} and Valley, {Dana R.} and Rohrer, {Daniel C.} and Scott Jewel and Philip Branton and Sobin, {Leslie H.} and Liqun Qi and Pushpa Hariharan and Shenpei Wu and David Tabor and Charles Shive and Smith, {Anna M.} and Buia, {Stephen A.} and Undale, {Anita H.} and Robinson, {Karna L.} and Nancy Roche and Valentino, {Kimberly M.} and Angela Britton and Robin Burges and Debra Bradbury and Hambright, {Kenneth W.} and John Seleski and Korzeniewski, {Greg E.} and Kenyon Erickson and Yvonne Marcus and Jorge Tejada and Mehran Taherian and Chunrong Lu and Robles, {Barnaby E.} and Margaret Basile and Mash, {Deborah C.} and Simona Volpi and Jeff Struewing and Temple, {Gary F.} and Joy Boyer and Deborah Colantuoni and Roger Little and Susan Koester and Carithers, {Latarsha J.} and Moore, {Helen M.} and Ping Guan and Carolyn Compton and Sawyer, {Sherilyn J.} and Demchok, {Joanne P.} and Vaught, {Jimmie B.} and Rabiner, {Chana A.} and Lockhart, {Nicole C.}",
year = "2015",
month = "10",
day = "19",
doi = "10.1038/srep15145",
language = "English (US)",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

AU - Yang, Jialiang

AU - Huang, Tao

AU - Petralia, Francesca

AU - Long, Quan

AU - Zhang, Bin

AU - Argmann, Carmen

AU - Zhao, Yong

AU - Mobbs, Charles V.

AU - Schadt, Eric E.

AU - Zhu, Jun

AU - Tu, Zhidong

AU - Ardlie, Kristin G.

AU - Deluca, David S.

AU - Segrè, Ayellet V.

AU - Sullivan, Timothy J.

AU - Young, Taylor R.

AU - Gelfand, Ellen T.

AU - Trowbridge, Casandra A.

AU - Maller, Julian B.

AU - Tukiainen, Taru

AU - Lek, Monkol

AU - Ward, Lucas D.

AU - Kheradpour, Pouya

AU - Iriarte, Benjamin

AU - Meng, Yan

AU - Palmer, Cameron D.

AU - Winckler, Wendy

AU - Hirschhorn, Joel

AU - Kellis, Manolis

AU - MacArthur, Daniel G.

AU - Getz, Gad

AU - Shablin, Andrey A.

AU - Li, Gen

AU - Zhou, Yi Hui

AU - Nobel, Andrew B.

AU - Rusyn, Ivan

AU - Wright, Fred A.

AU - Lappalainen, Tuuli

AU - Ferreira, Pedro G.

AU - Ongen, Halit

AU - Rivas, Manuel A.

AU - Battle, Alexis

AU - Mostafavi, Sara

AU - Monlong, Jean

AU - Sammeth, Michael

AU - Mele, Marta

AU - Reverter, Ferran

AU - Goldman, Jakob

AU - Koller, Daphne

AU - Guigo, Roderic

AU - McCarthy, Mark I.

AU - Dermitzakis, Emmanouil T.

AU - Gamazon, Eric R.

AU - Konkashbaev, Anuar

AU - Nicolae, Dan L.

AU - Cox, Nancy J.

AU - Flutre, Timothée

AU - Wen, Xiaoquan

AU - Stephens, Matthew

AU - Pritchard, Jonathan K.

AU - Lin, Luan

AU - Liu, Jun

AU - Brown, Amanda

AU - Mestichelli, Bernadette

AU - Tidwell, Denee

AU - Lo, Edmund

AU - Salvatore, Mike

AU - Shad, Saboor

AU - Thomas, Jeffrey A.

AU - Lonsdale, John T.

AU - Choi, Christopher

AU - Karasik, Ellen

AU - Ramsey, Kimberly

AU - Moser, Michael T.

AU - Foster, Barbara A.

AU - Gillard, Bryan M.

AU - Syron, John

AU - Fleming, Johnelle

AU - Magazine, Harold

AU - Hasz, Rick

AU - Walters, Gary D.

AU - Bridge, Jason P.

AU - Miklos, Mark

AU - Sullivan, Susan

AU - Barker, Laura K.

AU - Traino, Heather

AU - Mosavel, Magboeba

AU - Siminoff, Laura A.

AU - Valley, Dana R.

AU - Rohrer, Daniel C.

AU - Jewel, Scott

AU - Branton, Philip

AU - Sobin, Leslie H.

AU - Qi, Liqun

AU - Hariharan, Pushpa

AU - Wu, Shenpei

AU - Tabor, David

AU - Shive, Charles

AU - Smith, Anna M.

AU - Buia, Stephen A.

AU - Undale, Anita H.

AU - Robinson, Karna L.

AU - Roche, Nancy

AU - Valentino, Kimberly M.

AU - Britton, Angela

AU - Burges, Robin

AU - Bradbury, Debra

AU - Hambright, Kenneth W.

AU - Seleski, John

AU - Korzeniewski, Greg E.

AU - Erickson, Kenyon

AU - Marcus, Yvonne

AU - Tejada, Jorge

AU - Taherian, Mehran

AU - Lu, Chunrong

AU - Robles, Barnaby E.

AU - Basile, Margaret

AU - Mash, Deborah C.

AU - Volpi, Simona

AU - Struewing, Jeff

AU - Temple, Gary F.

AU - Boyer, Joy

AU - Colantuoni, Deborah

AU - Little, Roger

AU - Koester, Susan

AU - Carithers, Latarsha J.

AU - Moore, Helen M.

AU - Guan, Ping

AU - Compton, Carolyn

AU - Sawyer, Sherilyn J.

AU - Demchok, Joanne P.

AU - Vaught, Jimmie B.

AU - Rabiner, Chana A.

AU - Lockhart, Nicole C.

PY - 2015/10/19

Y1 - 2015/10/19

N2 - Aging is one of the most important biological processes and is a known risk factor for many age-related diseases in human. Studying age-related transcriptomic changes in tissues across the whole body can provide valuable information for a holistic understanding of this fundamental process. In this work, we catalogue age-related gene expression changes in nine tissues from nearly two hundred individuals collected by the Genotype-Tissue Expression (GTEx) project. In general, we find the aging gene expression signatures are very tissue specific. However, enrichment for some well-known aging components such as mitochondria biology is observed in many tissues. Different levels of cross-tissue synchronization of age-related gene expression changes are observed, and some essential tissues (e.g., heart and lung) show much stronger "co-aging" than other tissues based on a principal component analysis. The aging gene signatures and complex disease genes show a complex overlapping pattern and only in some cases, we see that they are significantly overlapped in the tissues affected by the corresponding diseases. In summary, our analyses provide novel insights to the co-regulation of age-related gene expression in multiple tissues; it also presents a tissue-specific view of the link between aging and age-related diseases.

AB - Aging is one of the most important biological processes and is a known risk factor for many age-related diseases in human. Studying age-related transcriptomic changes in tissues across the whole body can provide valuable information for a holistic understanding of this fundamental process. In this work, we catalogue age-related gene expression changes in nine tissues from nearly two hundred individuals collected by the Genotype-Tissue Expression (GTEx) project. In general, we find the aging gene expression signatures are very tissue specific. However, enrichment for some well-known aging components such as mitochondria biology is observed in many tissues. Different levels of cross-tissue synchronization of age-related gene expression changes are observed, and some essential tissues (e.g., heart and lung) show much stronger "co-aging" than other tissues based on a principal component analysis. The aging gene signatures and complex disease genes show a complex overlapping pattern and only in some cases, we see that they are significantly overlapped in the tissues affected by the corresponding diseases. In summary, our analyses provide novel insights to the co-regulation of age-related gene expression in multiple tissues; it also presents a tissue-specific view of the link between aging and age-related diseases.

UR - http://www.scopus.com/inward/record.url?scp=84945219231&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945219231&partnerID=8YFLogxK

U2 - 10.1038/srep15145

DO - 10.1038/srep15145

M3 - Article

C2 - 26477495

AN - SCOPUS:84945219231

VL - 5

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 15145

ER -