Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: A quantitative electron microscopic examination

Theresa A. Jones, Jeffrey A. Kleim, William T. Greenough

Research output: Contribution to journalArticle

184 Scopus citations

Abstract

Unilateral lesions of the forelimb area of the sensorimotor cortex in adult rats resulted in time-dependent increases in the number of synapses per neuron and the volume and membrane surface area of dendritic processes per neuron within layer V of the contralateral motor cortex in comparison to sham-operated rats. Based on previous findings of a behavioral relationship with increased dendritic arborization, these changes may be related to lesion-induced compensatory changes in the use of the non-impaired (ipsilateral to the lesion) forelimb.

Original languageEnglish (US)
Pages (from-to)142-148
Number of pages7
JournalBrain Research
Volume733
Issue number1
DOIs
StatePublished - Sep 9 1996
Externally publishedYes

Keywords

  • Forelimb behavior
  • Layer V
  • Motor cortex
  • Motor learning
  • Restoration of function
  • Stereology
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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