Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: A quantitative electron microscopic examination

Theresa A. Jones; Jeffrey A. Kleim; William T. Greenough

doi:10.1016/0006-8993(96)00792-5

Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: A quantitative electron microscopic examination

Theresa A. Jones, Jeffrey A. Kleim, William T. Greenough

Research output: Contribution to journal › Article › peer-review

203 Scopus citations

Abstract

Unilateral lesions of the forelimb area of the sensorimotor cortex in adult rats resulted in time-dependent increases in the number of synapses per neuron and the volume and membrane surface area of dendritic processes per neuron within layer V of the contralateral motor cortex in comparison to sham-operated rats. Based on previous findings of a behavioral relationship with increased dendritic arborization, these changes may be related to lesion-induced compensatory changes in the use of the non-impaired (ipsilateral to the lesion) forelimb.

Original language	English (US)
Pages (from-to)	142-148
Number of pages	7
Journal	Brain Research
Volume	733
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(96)00792-5
State	Published - Sep 9 1996
Externally published	Yes

Keywords

Forelimb behavior
Layer V
Motor cortex
Motor learning
Restoration of function
Stereology
Synaptic plasticity

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(96)00792-5

Cite this

@article{8391dfd217fc4fe0bb441b9a9f0f0323,

title = "Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: A quantitative electron microscopic examination",

abstract = "Unilateral lesions of the forelimb area of the sensorimotor cortex in adult rats resulted in time-dependent increases in the number of synapses per neuron and the volume and membrane surface area of dendritic processes per neuron within layer V of the contralateral motor cortex in comparison to sham-operated rats. Based on previous findings of a behavioral relationship with increased dendritic arborization, these changes may be related to lesion-induced compensatory changes in the use of the non-impaired (ipsilateral to the lesion) forelimb.",

keywords = "Forelimb behavior, Layer V, Motor cortex, Motor learning, Restoration of function, Stereology, Synaptic plasticity",

author = "Jones, {Theresa A.} and Kleim, {Jeffrey A.} and Greenough, {William T.}",

year = "1996",

month = sep,

day = "9",

doi = "10.1016/0006-8993(96)00792-5",

language = "English (US)",

volume = "733",

pages = "142--148",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats

T2 - A quantitative electron microscopic examination

AU - Jones, Theresa A.

AU - Kleim, Jeffrey A.

AU - Greenough, William T.

PY - 1996/9/9

Y1 - 1996/9/9

N2 - Unilateral lesions of the forelimb area of the sensorimotor cortex in adult rats resulted in time-dependent increases in the number of synapses per neuron and the volume and membrane surface area of dendritic processes per neuron within layer V of the contralateral motor cortex in comparison to sham-operated rats. Based on previous findings of a behavioral relationship with increased dendritic arborization, these changes may be related to lesion-induced compensatory changes in the use of the non-impaired (ipsilateral to the lesion) forelimb.

AB - Unilateral lesions of the forelimb area of the sensorimotor cortex in adult rats resulted in time-dependent increases in the number of synapses per neuron and the volume and membrane surface area of dendritic processes per neuron within layer V of the contralateral motor cortex in comparison to sham-operated rats. Based on previous findings of a behavioral relationship with increased dendritic arborization, these changes may be related to lesion-induced compensatory changes in the use of the non-impaired (ipsilateral to the lesion) forelimb.

KW - Forelimb behavior

KW - Layer V

KW - Motor cortex

KW - Motor learning

KW - Restoration of function

KW - Stereology

KW - Synaptic plasticity

UR - http://www.scopus.com/inward/record.url?scp=0030576878&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030576878&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(96)00792-5

DO - 10.1016/0006-8993(96)00792-5

M3 - Article

C2 - 8891261

AN - SCOPUS:0030576878

SN - 0006-8993

VL - 733

SP - 142

EP - 148

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: A quantitative electron microscopic examination

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this