Structure of Bryostatin 4. An Important Antineoplastic Constituent of Geographically Diverse Bugula neritina (Bryozoa)

George Pettit, Y. Kamano, C. L. Herald, M. Tozawa

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

A new antineoplastic macrocyclic lactone designated bryostatin 4 has been isolated from specimens of the marine bryozoan Bugula neritina (Linnaeus) collected in the Gulfs of California, Mexico, and Sagami (Japan). The discovery of bryostatin 4 in geographically distant collections of Bugula neritina suggests that such unique cell growth inhibitors may be true biosynthetic products of the animal. The structure (3) of bryostatin 4 was assigned employing high-resolution (400 MHz) 1H NMR and 13C NMR as well as solution phase secondary ion mass spectrometry techniques combined with results of hydrolysis experiments. Bryostatin 4 exhibited substantial cell growth inhibitory (PS cell line ED50, 10−3–10−4 μg/mL) and antineoplastic (PS, 62% increase in life extension at 46 μg/kg) properties.

Original languageEnglish (US)
Pages (from-to)6768-6771
Number of pages4
JournalJournal of the American Chemical Society
Volume106
Issue number22
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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