Structural basis for selectivity and diversity in angiotensin II receptors

Haitao Zhang, Gye Won Han, Alexander Batyuk, Andrii Ishchenko, Kate L. White, Nilkanth Patel, Anastasiia Sadybekov, Beata Zamlynny, Michael T. Rudd, Kaspar Hollenstein, Alexandra Tolstikova, Thomas A. White, Mark S. Hunter, Uwe Weierstall, Wei Liu, Kerim Babaoglu, Eric L. Moore, Ryan D. Katz, Jennifer M. Shipman, Margarita Garcia-CalvoSujata Sharma, Payal Sheth, Stephen M. Soisson, Raymond C. Stevens, Vsevolod Katritch, Vadim Cherezov

Research output: Contribution to journal › Article › peer-review

166 Scopus citations

3 results
- Relevance

XFEL structure of human angiotensin II type 2 receptor (Monoclinic form) in complex with compound 1 (N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl])
Zhang, H. (Contributor), Han, G. W. (Contributor), Batyuk, A. (Contributor), Ishchenko, A. (Contributor), White, K. L. (Contributor), Patel, N. (Contributor), Sadybekov, A. (Contributor), Zamlynny, B. (Contributor), Rudd, M. T. (Contributor), Hollenstein, K. (Contributor), Tolstikova, A. (Contributor), White, T. A. (Contributor), Hunter, M. S. (Contributor), Weierstall, U. (Contributor), Liu, W. (Contributor), Babaoglu, K. (Contributor), Moore, E. L. (Contributor), Katz, R. D. (Contributor), Shipman, J. M. (Contributor), Garcia-Calvo, M. (Contributor), Sharma, S. (Contributor), Sheth, P. (Contributor), Soisson, S. M. (Contributor), Stevens, R. C. (Contributor), Katritch, V. (Contributor) & Cherezov, V. (Contributor), Protein Data Bank (PDB), Apr 5 2017
DOI: 10.2210/pdb5UNF, https://www.wwpdb.org/pdb?id=pdb_00005unf
Dataset
XFEL structure of human angiotensin II type 2 receptor (Orthorhombic form) in complex with compound 1 (N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl] methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide)
Zhang, H. (Contributor), Han, G. W. (Contributor), Batyuk, A. (Contributor), Ishchenko, A. (Contributor), White, K. L. (Contributor), Patel, N. (Contributor), Sadybekov, A. (Contributor), Zamlynny, B. (Contributor), Rudd, M. T. (Contributor), Hollenstein, K. (Contributor), Tolstikova, A. (Contributor), White, T. A. (Contributor), Hunter, M. S. (Contributor), Weierstall, U. (Contributor), Liu, W. (Contributor), Babaoglu, K. (Contributor), Moore, E. L. (Contributor), Katz, R. D. (Contributor), Shipman, J. M. (Contributor), Garcia-Calvo, M. (Contributor), Sharma, S. (Contributor), Sheth, P. (Contributor), Soisson, S. M. (Contributor), Stevens, R. C. (Contributor), Katritch, V. (Contributor) & Cherezov, V. (Contributor), Protein Data Bank (PDB), Apr 5 2017
DOI: 10.2210/pdb5UNG, https://www.wwpdb.org/pdb?id=pdb_00005ung
Dataset
Synchrotron structure of human angiotensin II type 2 receptor in complex with compound 2 (N-[(furan-2-yl)methyl]-N-(4-oxo-2-propyl-3-{[2'-(2H-tetrazol-5-yl)[1,1'- biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)benzamide)
Zhang, H. (Contributor), Han, G. W. (Contributor), Batyuk, A. (Contributor), Ishchenko, A. (Contributor), White, K. L. (Contributor), Patel, N. (Contributor), Sadybekov, A. (Contributor), Zamlynny, B. (Contributor), Rudd, M. T. (Contributor), Hollenstein, K. (Contributor), Tolstikova, A. (Contributor), White, T. A. (Contributor), Hunter, M. S. (Contributor), Weierstall, U. (Contributor), Liu, W. (Contributor), Babaoglu, K. (Contributor), Moore, E. L. (Contributor), Katz, R. D. (Contributor), Shipman, J. M. (Contributor), Garcia-Calvo, M. (Contributor), Sharma, S. (Contributor), Sheth, P. (Contributor), Soisson, S. M. (Contributor), Stevens, R. C. (Contributor), Katritch, V. (Contributor) & Cherezov, V. (Contributor), Protein Data Bank (PDB), Apr 5 2017
DOI: 10.2210/pdb5UNH, https://www.wwpdb.org/pdb?id=pdb_00005unh
Dataset

Structural basis for selectivity and diversity in angiotensin II receptors

Datasets

Search results

XFEL structure of human angiotensin II type 2 receptor (Monoclinic form) in complex with compound 1 (N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl])

XFEL structure of human angiotensin II type 2 receptor (Orthorhombic form) in complex with compound 1 (N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl] methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide)

Synchrotron structure of human angiotensin II type 2 receptor in complex with compound 2 (N-[(furan-2-yl)methyl]-N-(4-oxo-2-propyl-3-{[2'-(2H-tetrazol-5-yl)[1,1'- biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)benzamide)