Oxygenation of the 14α-methyl group in 3β-acetoxy-7α- hydroxy-14α-methyl-5α-cholestane has been achieved by reaction with lead tetra-acetate. Cleavage of the resulting 7α,32-epoxide with pyridine hydrochloride in refluxing acetic anhydride gave 3β-acetoxy-14α- acetoxymethyl-5α-cholest-7-ene, while chromium trioxide in acetic acid afforded the lactol derived from 3β-acetoxy-7-oxo-5α-cholestane- 14α-carboxylic acid.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of the Chemical Society C: Organic Chemistry|
|State||Published - 1967|
ASJC Scopus subject areas
- Organic Chemistry