Steroids and related natural products. Part XLI. 14α-Methyl Œstranes

George Pettit; Thomas H. Brown

doi:10.1039/J39670002024

Steroids and related natural products. Part XLI. 14α-Methyl Œstranes

George Pettit, Thomas H. Brown

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

Œstrone has been converted into 14α-methylœstr-4-ene-3, 15-dione (V) in 14 steps. Direct alkylation at position 14 (activated by a 15-oxo-group) proved convenient for introducing the angular methyl group. Configuration of the 14-methyl substituent was established by o.r.d. measurements.

Original language	English (US)
Pages (from-to)	2024-2026
Number of pages	3
Journal	Journal of the Chemical Society C: Organic Chemistry
DOIs	https://doi.org/10.1039/J39670002024
State	Published - Dec 1 1967

ASJC Scopus subject areas

Organic Chemistry

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10.1039/J39670002024

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Pettit, G., & Brown, T. H. (1967). Steroids and related natural products. Part XLI. 14α-Methyl Œstranes. Journal of the Chemical Society C: Organic Chemistry, 2024-2026. https://doi.org/10.1039/J39670002024

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abstract = "{\OE}strone has been converted into 14α-methyl{\oe}str-4-ene-3, 15-dione (V) in 14 steps. Direct alkylation at position 14 (activated by a 15-oxo-group) proved convenient for introducing the angular methyl group. Configuration of the 14-methyl substituent was established by o.r.d. measurements.",

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