Stereoselective synthesis of the atropisomers of myristinin B/C

David J. Maloney, Shengxi Chen, Sidney Hecht

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The first stereoselective synthesis of a potent DNA damaging agent, (-)-myristinin B/C, has been accomplished. This efficient synthesis allowed for unambiguous confirmation of the structure and absolute stereochemistry of the atropisomeric natural product. The antipode, (+)-myristinin B/C, was also synthesized, providing ample material for biological evaluation of both enantiomers.

Original languageEnglish (US)
Pages (from-to)1925-1927
Number of pages3
JournalOrganic Letters
Volume8
Issue number9
DOIs
StatePublished - Apr 27 2006
Externally publishedYes

Fingerprint

antipodes
Stereochemistry
Enantiomers
enantiomers
stereochemistry
synthesis
Biological Products
deoxyribonucleic acid
evaluation
DNA
products
myristinin B
myristinin C

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Stereoselective synthesis of the atropisomers of myristinin B/C. / Maloney, David J.; Chen, Shengxi; Hecht, Sidney.

In: Organic Letters, Vol. 8, No. 9, 27.04.2006, p. 1925-1927.

Research output: Contribution to journalArticle

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