Stereoselective synthesis of the atropisomers of myristinin B/C

David J. Maloney, Shengxi Chen, Sidney M. Hecht

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The first stereoselective synthesis of a potent DNA damaging agent, (-)-myristinin B/C, has been accomplished. This efficient synthesis allowed for unambiguous confirmation of the structure and absolute stereochemistry of the atropisomeric natural product. The antipode, (+)-myristinin B/C, was also synthesized, providing ample material for biological evaluation of both enantiomers.

Original languageEnglish (US)
Pages (from-to)1925-1927
Number of pages3
JournalOrganic Letters
Volume8
Issue number9
DOIs
StatePublished - Apr 27 2006

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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