The first stereoselective synthesis of a potent DNA damaging agent, (-)-myristinin B/C, has been accomplished. This efficient synthesis allowed for unambiguous confirmation of the structure and absolute stereochemistry of the atropisomeric natural product. The antipode, (+)-myristinin B/C, was also synthesized, providing ample material for biological evaluation of both enantiomers.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Apr 27 2006|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry