Sleep, Positive Affect, and Circulating Interleukin-6 in Women With Temporomandibular Joint Disorder

Carly A. Hunt, Chung Jung Mun, Michael A. Owens, Sheera F. Lerman, Shriya Kunatharaju, Howard A. Tennen, Luis F. Buenaver, Claudia M. Campbell, Jennifer A. Haythornthwaite, Michael T. Smith, Patrick H. Finan

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Systemic inflammation is commonly observed in idiopathic chronic pain conditions, including temporomandibular joint disorder (TMD). Trait positive affect (PA) is associated with lower inflammation in healthy controls, but those effects may be threatened by poor sleep. The associations between PA with proinflammatory cytokine activity and potential moderation by sleep in chronic pain are not known. We thus investigated the association between PA and circulating interleukin-6 (IL-6) and moderation of that association by sleep in a sample of women with TMD and sleep difficulties. Methods: Participants (n = 110) completed the insomnia severity index and provided blood samples at five intervals throughout an evoked pain testing session. They then completed a 14-day diary assessing sleep and affect, along with wrist actigraphy. Results: There was not a significant main effect of PA on resting or pain-evoked IL-6 (b = 0.04, p = .33). Diary total sleep time (b = −0.002, p = .008), sleep efficiency (b = −0.01, p = .005), sleep onset latency (b = 0.006, p = .010), and wake after sleep onset (b = 0.003, p = .033) interacted with PA to predict IL-6, such that PA inversely predicted IL-6 at higher levels of total sleep time and sleep efficiency and at lower levels of sleep onset latency and wake after sleep onset. Surprisingly, when sleep was poor, PA predicted greater IL-6. Conclusions: The potential salutary effects of PA on resting IL-6 erode when sleep is poor, underscoring the importance of considering sleep in conceptual and intervention models of TMD.

Original languageEnglish (US)
Pages (from-to)383-392
Number of pages10
JournalPsychosomatic Medicine
Volume84
Issue number3
DOIs
StatePublished - Apr 1 2022

Keywords

  • idiopathic pain
  • insomnia
  • interleukin-6
  • positive affect
  • sleep
  • temporomandibular disorder

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

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